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Association of genetic variants with hypertension in a longitudinal population-based genetic epidemiological study.

Yamada Y, Matsui K, Takeuchi I, Oguri M, Fujimaki T - Int. J. Mol. Med. (2015)

Bottom Line: The subjects were recruited from individuals who visited the Health Care Center of Inabe General Hospital for an annual health checkup, and they are followed up each year (mean follow‑up period, 5 years).Longitudinal analysis with a generalized estimating equation and with adjustment for age, gender, body mass index and smoking status revealed that rs2116519 of family with sequence similarity 78, member B (FAM78B; P=0.0266), rs6929846 of butyrophilin, subfamily 2, member A1 (BTN2A1; P=0.0013), rs146021107 of pancreatic and duodenal homeobox 1 (PDX1; P=0.0031) and rs1671021 of lethal giant larvae homolog 2 (Drosophila) (LLGL2; P=0.0372) were significantly (P<0.05) associated with the prevalence of hypertension.Longitudinal analysis with a generalized linear mixed-effect model and with adjustment for age, gender, body mass index and smoking status among individuals not taking anti-hypertensive medication revealed that rs6929846 of BTN2A1 was significantly associated with systolic (P=0.0017), diastolic (P=0.0008) and mean (P=0.0005) BP, and that rs2116519 of FAM78B, rs146021107 of PDX1 and rs1671021 of LLGL2 were significantly associated with diastolic (P=0.0495), systolic (P=0.0132), and both diastolic (P=0.0468) and mean (0.0471) BP, respectively.

View Article: PubMed Central - PubMed

Affiliation: Department of Human Functional Genomics, Life Science Research Center, Mie University, Tsu, Mie 514‑8507, Japan.

ABSTRACT
We previously identified 9 genes and chromosomal region 3q28 as susceptibility loci for Japanese patients with myocardial infarction, ischemic stroke, or chronic kidney disease by genome-wide or candidate gene association studies. In the present study, we investigated the possible association of 13 single nucleotide polymorphisms (SNPs) at these 10 loci with the prevalence of hypertension or their association with blood pressure (BP) in community-dwelling individuals in Japan. The study subjects comprised 6,027 individuals (2,250 subjects with essential hypertension, 3,777 controls) who were recruited into the Inabe Health and Longevity Study, a longitudinal genetic epidemiological study on atherosclerotic, cardiovascular and metabolic diseases. The subjects were recruited from individuals who visited the Health Care Center of Inabe General Hospital for an annual health checkup, and they are followed up each year (mean follow‑up period, 5 years). Longitudinal analysis with a generalized estimating equation and with adjustment for age, gender, body mass index and smoking status revealed that rs2116519 of family with sequence similarity 78, member B (FAM78B; P=0.0266), rs6929846 of butyrophilin, subfamily 2, member A1 (BTN2A1; P=0.0013), rs146021107 of pancreatic and duodenal homeobox 1 (PDX1; P=0.0031) and rs1671021 of lethal giant larvae homolog 2 (Drosophila) (LLGL2; P=0.0372) were significantly (P<0.05) associated with the prevalence of hypertension. Longitudinal analysis with a generalized linear mixed-effect model and with adjustment for age, gender, body mass index and smoking status among individuals not taking anti-hypertensive medication revealed that rs6929846 of BTN2A1 was significantly associated with systolic (P=0.0017), diastolic (P=0.0008) and mean (P=0.0005) BP, and that rs2116519 of FAM78B, rs146021107 of PDX1 and rs1671021 of LLGL2 were significantly associated with diastolic (P=0.0495), systolic (P=0.0132), and both diastolic (P=0.0468) and mean (0.0471) BP, respectively. BTN2A1 may thus be a susceptibility gene for hypertension.

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Longitudinal analysis with a generalized linear mixed-effect model of the association between (A) systolic or (B) diastolic blood pressure (BP) and age according to genotype for rs6929846 of BTN2A1 (CC vs. CT + TT), (C) between systolic BP and age according to genotype for rs146021107 of PDX1 (GG vs. G/- + -/-), or (D) between diastolic BP and age according to genotype for rs1671021 of LLGL2 (AA vs. AG + GG) among individuals not taking any anti-hypertensive medication.
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f2-ijmm-35-05-1189: Longitudinal analysis with a generalized linear mixed-effect model of the association between (A) systolic or (B) diastolic blood pressure (BP) and age according to genotype for rs6929846 of BTN2A1 (CC vs. CT + TT), (C) between systolic BP and age according to genotype for rs146021107 of PDX1 (GG vs. G/- + -/-), or (D) between diastolic BP and age according to genotype for rs1671021 of LLGL2 (AA vs. AG + GG) among individuals not taking any anti-hypertensive medication.

Mentions: The association between systolic or diastolic BP and age in individuals not taking any anti-hypertensive medication was analyzed longitudinally according to genotype with a generalized linear mixed-effect model (Fig. 2). Systolic (Fig. 2A) and diastolic (Fig. 2B) BP were greater in the combined group of individuals with the CT or TT genotypes of rs6929846 of BTN2A1 than in those with the CC genotype from 40 to 90 years of age. Systolic BP was greater in subjects with the GG genotype of rs146021107 of PDX1 than in the combined group of individuals with the G/- or -/- genotypes (Fig. 2C). Diastolic BP was greater in the combined group of individuals with the AG or GG genotypes of rs1671021 of LLGL2 than in those with the AA genotype (Fig. 2D).


Association of genetic variants with hypertension in a longitudinal population-based genetic epidemiological study.

Yamada Y, Matsui K, Takeuchi I, Oguri M, Fujimaki T - Int. J. Mol. Med. (2015)

Longitudinal analysis with a generalized linear mixed-effect model of the association between (A) systolic or (B) diastolic blood pressure (BP) and age according to genotype for rs6929846 of BTN2A1 (CC vs. CT + TT), (C) between systolic BP and age according to genotype for rs146021107 of PDX1 (GG vs. G/- + -/-), or (D) between diastolic BP and age according to genotype for rs1671021 of LLGL2 (AA vs. AG + GG) among individuals not taking any anti-hypertensive medication.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4380208&req=5

f2-ijmm-35-05-1189: Longitudinal analysis with a generalized linear mixed-effect model of the association between (A) systolic or (B) diastolic blood pressure (BP) and age according to genotype for rs6929846 of BTN2A1 (CC vs. CT + TT), (C) between systolic BP and age according to genotype for rs146021107 of PDX1 (GG vs. G/- + -/-), or (D) between diastolic BP and age according to genotype for rs1671021 of LLGL2 (AA vs. AG + GG) among individuals not taking any anti-hypertensive medication.
Mentions: The association between systolic or diastolic BP and age in individuals not taking any anti-hypertensive medication was analyzed longitudinally according to genotype with a generalized linear mixed-effect model (Fig. 2). Systolic (Fig. 2A) and diastolic (Fig. 2B) BP were greater in the combined group of individuals with the CT or TT genotypes of rs6929846 of BTN2A1 than in those with the CC genotype from 40 to 90 years of age. Systolic BP was greater in subjects with the GG genotype of rs146021107 of PDX1 than in the combined group of individuals with the G/- or -/- genotypes (Fig. 2C). Diastolic BP was greater in the combined group of individuals with the AG or GG genotypes of rs1671021 of LLGL2 than in those with the AA genotype (Fig. 2D).

Bottom Line: The subjects were recruited from individuals who visited the Health Care Center of Inabe General Hospital for an annual health checkup, and they are followed up each year (mean follow‑up period, 5 years).Longitudinal analysis with a generalized estimating equation and with adjustment for age, gender, body mass index and smoking status revealed that rs2116519 of family with sequence similarity 78, member B (FAM78B; P=0.0266), rs6929846 of butyrophilin, subfamily 2, member A1 (BTN2A1; P=0.0013), rs146021107 of pancreatic and duodenal homeobox 1 (PDX1; P=0.0031) and rs1671021 of lethal giant larvae homolog 2 (Drosophila) (LLGL2; P=0.0372) were significantly (P<0.05) associated with the prevalence of hypertension.Longitudinal analysis with a generalized linear mixed-effect model and with adjustment for age, gender, body mass index and smoking status among individuals not taking anti-hypertensive medication revealed that rs6929846 of BTN2A1 was significantly associated with systolic (P=0.0017), diastolic (P=0.0008) and mean (P=0.0005) BP, and that rs2116519 of FAM78B, rs146021107 of PDX1 and rs1671021 of LLGL2 were significantly associated with diastolic (P=0.0495), systolic (P=0.0132), and both diastolic (P=0.0468) and mean (0.0471) BP, respectively.

View Article: PubMed Central - PubMed

Affiliation: Department of Human Functional Genomics, Life Science Research Center, Mie University, Tsu, Mie 514‑8507, Japan.

ABSTRACT
We previously identified 9 genes and chromosomal region 3q28 as susceptibility loci for Japanese patients with myocardial infarction, ischemic stroke, or chronic kidney disease by genome-wide or candidate gene association studies. In the present study, we investigated the possible association of 13 single nucleotide polymorphisms (SNPs) at these 10 loci with the prevalence of hypertension or their association with blood pressure (BP) in community-dwelling individuals in Japan. The study subjects comprised 6,027 individuals (2,250 subjects with essential hypertension, 3,777 controls) who were recruited into the Inabe Health and Longevity Study, a longitudinal genetic epidemiological study on atherosclerotic, cardiovascular and metabolic diseases. The subjects were recruited from individuals who visited the Health Care Center of Inabe General Hospital for an annual health checkup, and they are followed up each year (mean follow‑up period, 5 years). Longitudinal analysis with a generalized estimating equation and with adjustment for age, gender, body mass index and smoking status revealed that rs2116519 of family with sequence similarity 78, member B (FAM78B; P=0.0266), rs6929846 of butyrophilin, subfamily 2, member A1 (BTN2A1; P=0.0013), rs146021107 of pancreatic and duodenal homeobox 1 (PDX1; P=0.0031) and rs1671021 of lethal giant larvae homolog 2 (Drosophila) (LLGL2; P=0.0372) were significantly (P<0.05) associated with the prevalence of hypertension. Longitudinal analysis with a generalized linear mixed-effect model and with adjustment for age, gender, body mass index and smoking status among individuals not taking anti-hypertensive medication revealed that rs6929846 of BTN2A1 was significantly associated with systolic (P=0.0017), diastolic (P=0.0008) and mean (P=0.0005) BP, and that rs2116519 of FAM78B, rs146021107 of PDX1 and rs1671021 of LLGL2 were significantly associated with diastolic (P=0.0495), systolic (P=0.0132), and both diastolic (P=0.0468) and mean (0.0471) BP, respectively. BTN2A1 may thus be a susceptibility gene for hypertension.

Show MeSH
Related in: MedlinePlus