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The apolipoprotein B/apolipoprotein A-I ratio as a potential marker of plasma atherogenicity.

Kaneva AM, Potolitsyna NN, Bojko ER, Odland JØ - Dis. Markers (2015)

Bottom Line: The apolipoprotein (apo) B/apoA-I ratio represents the balance between apoB-rich atherogenic particles and apoA-I-rich antiatherogenic particles, and this ratio is considered to be a marker of cardiovascular risk.A total of 157 normolipidemic men aged 20-59 years were included in the study.Despite normolipidemia, the subjects with the unfavorable apoB/apoA-I ratio had more atherogenic lipid profile.

View Article: PubMed Central - PubMed

Affiliation: Institute of Physiology, Komi Science Center, Ural Branch of Russian Academy of Sciences, Pervomaiskaya Avenue 50, Syktyvkar 167982, Russia.

ABSTRACT

Background: The apolipoprotein (apo) B/apoA-I ratio represents the balance between apoB-rich atherogenic particles and apoA-I-rich antiatherogenic particles, and this ratio is considered to be a marker of cardiovascular risk. Although many studies have demonstrated the importance of the apoB/apoA-I ratio in predicting the presence or absence of cardiovascular disease, less is known about apoB/apoA-I ratio as a marker of plasma atherogenicity.

Methods: A total of 157 normolipidemic men aged 20-59 years were included in the study. The plasma levels of total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), apoA-I, apoB, and apoE were determined after a 12 h fasting period.

Results: The median of the apoB/apoA-I ratio in the studied normolipidemic subjects was 0.52, with values ranging from 0.19 to 2.60. The percentage of subjects with the apoB/apoA-I ratio exceeding 0.9 (the accepted risk value of cardiovascular disease) was 19.1%. The subjects with apoB/apoA-I>0.9 were characterized by higher TG levels and atherogenic index of plasma (AIP) and lower values of ratio of low-density lipoprotein cholesterol (LDL-C) to apoB (LDL-C/apoB) and apoE levels compared with men with apoB/apoA-I<0.9.

Conclusion: Despite normolipidemia, the subjects with the unfavorable apoB/apoA-I ratio had more atherogenic lipid profile.

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Related in: MedlinePlus

Distribution of subjects depending on the apoA-I and apoB levels in the groups with apoB/apoA-I<0.9 and apoB/apoA-I>0.9. Values of apoB>120 mg/dL and apoA-I<120 mg/dL have been proposed as the cut-off points defining a high cardiovascular risk [21, 22].
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fig1: Distribution of subjects depending on the apoA-I and apoB levels in the groups with apoB/apoA-I<0.9 and apoB/apoA-I>0.9. Values of apoB>120 mg/dL and apoA-I<120 mg/dL have been proposed as the cut-off points defining a high cardiovascular risk [21, 22].

Mentions: The median value (25%; 75%) of the apoB/apoA-I ratio for the entire group was 0.52 (0.42; 0.78), with values ranging from 0.19 to 2.60. By virtue of the exclusion criteria, the plasma TC, TG, and HDL-C levels in the men varied in the health-related reference interval. Nevertheless, of the 157 studied subjects, 30 men (19.1%) had the apoB/apoA-I ratio above 0.9. The values of apoB and apoA-I varied from 30.0 to 218.0 mg/dL and from 50.0 to 300.0 mg/dL, respectively. According to the health-related reference values of apoproteins [21, 22], low values of apoA-I were determined in 14 subjects, and high values of apoB were found in 9 men of 30 subjects with the unfavourable apoB/apoA-I ratio. Seven subjects had low levels of apoA-I along with high levels of apoB. In the group of men with apoB/apoA-I<0.9, low values of apoA-I and high values of apoB were observed in 33 and 5 subjects (26.0% and 3.1% of the total cases), respectively (Figure 1).


The apolipoprotein B/apolipoprotein A-I ratio as a potential marker of plasma atherogenicity.

Kaneva AM, Potolitsyna NN, Bojko ER, Odland JØ - Dis. Markers (2015)

Distribution of subjects depending on the apoA-I and apoB levels in the groups with apoB/apoA-I<0.9 and apoB/apoA-I>0.9. Values of apoB>120 mg/dL and apoA-I<120 mg/dL have been proposed as the cut-off points defining a high cardiovascular risk [21, 22].
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4380097&req=5

fig1: Distribution of subjects depending on the apoA-I and apoB levels in the groups with apoB/apoA-I<0.9 and apoB/apoA-I>0.9. Values of apoB>120 mg/dL and apoA-I<120 mg/dL have been proposed as the cut-off points defining a high cardiovascular risk [21, 22].
Mentions: The median value (25%; 75%) of the apoB/apoA-I ratio for the entire group was 0.52 (0.42; 0.78), with values ranging from 0.19 to 2.60. By virtue of the exclusion criteria, the plasma TC, TG, and HDL-C levels in the men varied in the health-related reference interval. Nevertheless, of the 157 studied subjects, 30 men (19.1%) had the apoB/apoA-I ratio above 0.9. The values of apoB and apoA-I varied from 30.0 to 218.0 mg/dL and from 50.0 to 300.0 mg/dL, respectively. According to the health-related reference values of apoproteins [21, 22], low values of apoA-I were determined in 14 subjects, and high values of apoB were found in 9 men of 30 subjects with the unfavourable apoB/apoA-I ratio. Seven subjects had low levels of apoA-I along with high levels of apoB. In the group of men with apoB/apoA-I<0.9, low values of apoA-I and high values of apoB were observed in 33 and 5 subjects (26.0% and 3.1% of the total cases), respectively (Figure 1).

Bottom Line: The apolipoprotein (apo) B/apoA-I ratio represents the balance between apoB-rich atherogenic particles and apoA-I-rich antiatherogenic particles, and this ratio is considered to be a marker of cardiovascular risk.A total of 157 normolipidemic men aged 20-59 years were included in the study.Despite normolipidemia, the subjects with the unfavorable apoB/apoA-I ratio had more atherogenic lipid profile.

View Article: PubMed Central - PubMed

Affiliation: Institute of Physiology, Komi Science Center, Ural Branch of Russian Academy of Sciences, Pervomaiskaya Avenue 50, Syktyvkar 167982, Russia.

ABSTRACT

Background: The apolipoprotein (apo) B/apoA-I ratio represents the balance between apoB-rich atherogenic particles and apoA-I-rich antiatherogenic particles, and this ratio is considered to be a marker of cardiovascular risk. Although many studies have demonstrated the importance of the apoB/apoA-I ratio in predicting the presence or absence of cardiovascular disease, less is known about apoB/apoA-I ratio as a marker of plasma atherogenicity.

Methods: A total of 157 normolipidemic men aged 20-59 years were included in the study. The plasma levels of total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), apoA-I, apoB, and apoE were determined after a 12 h fasting period.

Results: The median of the apoB/apoA-I ratio in the studied normolipidemic subjects was 0.52, with values ranging from 0.19 to 2.60. The percentage of subjects with the apoB/apoA-I ratio exceeding 0.9 (the accepted risk value of cardiovascular disease) was 19.1%. The subjects with apoB/apoA-I>0.9 were characterized by higher TG levels and atherogenic index of plasma (AIP) and lower values of ratio of low-density lipoprotein cholesterol (LDL-C) to apoB (LDL-C/apoB) and apoE levels compared with men with apoB/apoA-I<0.9.

Conclusion: Despite normolipidemia, the subjects with the unfavorable apoB/apoA-I ratio had more atherogenic lipid profile.

Show MeSH
Related in: MedlinePlus