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Serum creatinine level: a supplemental index to distinguish Duchenne muscular dystrophy from Becker muscular dystrophy.

Zhang H, Zhu Y, Sun Y, Liang Y, Li Y, Zhang Y, Deng L, Wen X, Zhang C - Dis. Markers (2015)

Bottom Line: Serum Crn level had a strong inverse correlation with Vignos score by simple correlation (r = -0.793) and partial correlation analysis after adjustment for age, height, and weight (r = -0.791; both P < 0.01).After adjusting for age, height, and weight, BMD patients still had a significantly higher serum Crn level than DMD patients (β = 7.140,  t = 6.277,  P < 0.01).Serum Crn level reflected disease severity and may serve as a supplemental index to distinguish DMD from BMD in clinical practice.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurology, First Affiliated Hospital, Sun Yat-sen University, No. 58 Zhongshan 2nd Road, Guangzhou 510080, China.

ABSTRACT

Background: To improve assessment of dystrophinopathy, the aim of this study was to identify whether serum creatinine (Crn) level reflects disease severity.

Methods: Biochemical, Vignos score, and genetic data were collected on 212 boys with dystrophinopathy.

Results: Serum Crn level had a strong inverse correlation with Vignos score by simple correlation (r = -0.793) and partial correlation analysis after adjustment for age, height, and weight (r = -0.791; both P < 0.01). Serum Crn level was significantly higher in patients with in-frame than out-of-frame mutations (Z = -4.716,  P < 0.01) and in Becker muscular dystrophy (BMD) patients than Duchenne muscular dystrophy (DMD) patients at ages 4, 5, 7, and 9 yr (all P < 0.0125). After adjusting for age, height, and weight, BMD patients still had a significantly higher serum Crn level than DMD patients (β = 7.140,  t = 6.277,  P < 0.01).

Conclusions: Serum Crn level reflected disease severity and may serve as a supplemental index to distinguish DMD from BMD in clinical practice.

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Related in: MedlinePlus

Serum creatinine (Crn) level is inversely correlated with Vignos scale scores.
© Copyright Policy - open-access
Related In: Results  -  Collection


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fig1: Serum creatinine (Crn) level is inversely correlated with Vignos scale scores.

Mentions: Vignos scale data were available for only 187 patients. Serum Crn level had a strong inverse correlation with Vignos score (r = −0.793, P < 0.05; Figure 1); this correlation remained after adjustment for age, height, and weight (r = −0.791, P < 0.05).


Serum creatinine level: a supplemental index to distinguish Duchenne muscular dystrophy from Becker muscular dystrophy.

Zhang H, Zhu Y, Sun Y, Liang Y, Li Y, Zhang Y, Deng L, Wen X, Zhang C - Dis. Markers (2015)

Serum creatinine (Crn) level is inversely correlated with Vignos scale scores.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4380093&req=5

fig1: Serum creatinine (Crn) level is inversely correlated with Vignos scale scores.
Mentions: Vignos scale data were available for only 187 patients. Serum Crn level had a strong inverse correlation with Vignos score (r = −0.793, P < 0.05; Figure 1); this correlation remained after adjustment for age, height, and weight (r = −0.791, P < 0.05).

Bottom Line: Serum Crn level had a strong inverse correlation with Vignos score by simple correlation (r = -0.793) and partial correlation analysis after adjustment for age, height, and weight (r = -0.791; both P < 0.01).After adjusting for age, height, and weight, BMD patients still had a significantly higher serum Crn level than DMD patients (β = 7.140,  t = 6.277,  P < 0.01).Serum Crn level reflected disease severity and may serve as a supplemental index to distinguish DMD from BMD in clinical practice.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurology, First Affiliated Hospital, Sun Yat-sen University, No. 58 Zhongshan 2nd Road, Guangzhou 510080, China.

ABSTRACT

Background: To improve assessment of dystrophinopathy, the aim of this study was to identify whether serum creatinine (Crn) level reflects disease severity.

Methods: Biochemical, Vignos score, and genetic data were collected on 212 boys with dystrophinopathy.

Results: Serum Crn level had a strong inverse correlation with Vignos score by simple correlation (r = -0.793) and partial correlation analysis after adjustment for age, height, and weight (r = -0.791; both P < 0.01). Serum Crn level was significantly higher in patients with in-frame than out-of-frame mutations (Z = -4.716,  P < 0.01) and in Becker muscular dystrophy (BMD) patients than Duchenne muscular dystrophy (DMD) patients at ages 4, 5, 7, and 9 yr (all P < 0.0125). After adjusting for age, height, and weight, BMD patients still had a significantly higher serum Crn level than DMD patients (β = 7.140,  t = 6.277,  P < 0.01).

Conclusions: Serum Crn level reflected disease severity and may serve as a supplemental index to distinguish DMD from BMD in clinical practice.

Show MeSH
Related in: MedlinePlus