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Spatial olfactory learning contributes to place field formation in the hippocampus.

Zhang S, Manahan-Vaughan D - Cereb. Cortex (2013)

Bottom Line: Nevertheless, hippocampus does not only use visual cues to generate spatial representations.Here, we report that learning about a distinct odor constellation in an environment, where visual and auditory cues are suppressed, results in stable place fields that rotate when the odor constellations are rotated and remap when the odor constellations are shuffled.Despite the less precise nature of olfactory stimuli compared with visual stimuli, these can substitute for visual inputs to enable the acquisition of metric information about space.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurophysiology, Medical Faculty and International Graduate School for Neuroscience, Ruhr University Bochum, 44780 Bochum, Germany.

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Related in: MedlinePlus

Calculations of firing rate in each session. Average firing rate, peak firing rate, infield firing rate, and outfield firing rate of place cells in each session were calculated and plotted in bar charts for the test group (a,c,e,g) and for the control group (b,d,f,h). Data in each session were compared with those in a previous/following session by t-test or paired t-test. No significant difference was observed (bar charts: mean ± SEM).
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BHT239F9: Calculations of firing rate in each session. Average firing rate, peak firing rate, infield firing rate, and outfield firing rate of place cells in each session were calculated and plotted in bar charts for the test group (a,c,e,g) and for the control group (b,d,f,h). Data in each session were compared with those in a previous/following session by t-test or paired t-test. No significant difference was observed (bar charts: mean ± SEM).

Mentions: The average firing rate was calculated by dividing the number of spikes recorded over the entire session by the duration of the session. The peak firing rate was defined as the highest firing rate of all pixels in the rate map of a place field. Mean infield and outfield firing rates were defined as the average firing rates of all pixels within (infield) and outside (outfield) the place field. None of these measures was significantly altered across the protocol (Fig. 9). The average velocity of animals was not significantly altered and the behavioral status was not notable changed (Supplementary Fig. 5). This excludes the likelihood that changes in these parameters influenced the outcome of the place field patterns in the various conditions.Figure 9.


Spatial olfactory learning contributes to place field formation in the hippocampus.

Zhang S, Manahan-Vaughan D - Cereb. Cortex (2013)

Calculations of firing rate in each session. Average firing rate, peak firing rate, infield firing rate, and outfield firing rate of place cells in each session were calculated and plotted in bar charts for the test group (a,c,e,g) and for the control group (b,d,f,h). Data in each session were compared with those in a previous/following session by t-test or paired t-test. No significant difference was observed (bar charts: mean ± SEM).
© Copyright Policy - creative-commons
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4380081&req=5

BHT239F9: Calculations of firing rate in each session. Average firing rate, peak firing rate, infield firing rate, and outfield firing rate of place cells in each session were calculated and plotted in bar charts for the test group (a,c,e,g) and for the control group (b,d,f,h). Data in each session were compared with those in a previous/following session by t-test or paired t-test. No significant difference was observed (bar charts: mean ± SEM).
Mentions: The average firing rate was calculated by dividing the number of spikes recorded over the entire session by the duration of the session. The peak firing rate was defined as the highest firing rate of all pixels in the rate map of a place field. Mean infield and outfield firing rates were defined as the average firing rates of all pixels within (infield) and outside (outfield) the place field. None of these measures was significantly altered across the protocol (Fig. 9). The average velocity of animals was not significantly altered and the behavioral status was not notable changed (Supplementary Fig. 5). This excludes the likelihood that changes in these parameters influenced the outcome of the place field patterns in the various conditions.Figure 9.

Bottom Line: Nevertheless, hippocampus does not only use visual cues to generate spatial representations.Here, we report that learning about a distinct odor constellation in an environment, where visual and auditory cues are suppressed, results in stable place fields that rotate when the odor constellations are rotated and remap when the odor constellations are shuffled.Despite the less precise nature of olfactory stimuli compared with visual stimuli, these can substitute for visual inputs to enable the acquisition of metric information about space.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurophysiology, Medical Faculty and International Graduate School for Neuroscience, Ruhr University Bochum, 44780 Bochum, Germany.

Show MeSH
Related in: MedlinePlus