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In vivo measurement of dose distribution in patients' lymphocytes: helical tomotherapy versus step-and-shoot IMRT in prostate cancer.

Zwicker F, Swartman B, Roeder F, Sterzing F, Hauswald H, Thieke C, Weber KJ, Huber PE, Schubert K, Debus J, Herfarth K - J. Radiat. Res. (2014)

Bottom Line: The isolated leukocytes were fixed 2 h after radiation.The dose exposure range, between 45 and 100%, was equal with both radiation techniques.Differences in the constructional buildup of the different linear accelerator systems, e.g. the flattening filter, may be the cause thereof.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiation Oncology, University of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany Clinical Cooperation Unit Radiation Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany f.zwicker@dkfz.de.

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Analyses of dose–volume histograms (DVH) of patients' PTV prostate of the SSIMRT and the TOMO group (20 patients each): (a) mean relative dose maximum (D max) of the prescribed dose in the PTV prostate, and (b) mean relative volume (V) of PTV prostate that received dose more than 102% of the prescribed dose (D > 102%). Standard errors are shown.
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RRU096F5: Analyses of dose–volume histograms (DVH) of patients' PTV prostate of the SSIMRT and the TOMO group (20 patients each): (a) mean relative dose maximum (D max) of the prescribed dose in the PTV prostate, and (b) mean relative volume (V) of PTV prostate that received dose more than 102% of the prescribed dose (D > 102%). Standard errors are shown.

Mentions: Analyses of dose–volume histograms of patients' PTVs (Fig. 5) for the two groups (SSIMRT and TOMO) showed the following results: the mean dose maximum (Dmax) of the prescribed dose in the PTV prostate was 107.8% (standard error: 0.389) in the SSIMRT group and 104.3% (standard error: 0.415) in the TOMO group. The difference was significant (P ≤ 0.05). The mean volume (V) of the prostate PTV that received a dose more than 102% of the prescribed dose (D > 102%) was 30.2% (standard error: 2.49; range: 8–47%) in the SSIMRT group and 4.57% (standard error: 0.61; range: 1–9%) in the TOMO group. This difference was also significant (P ≤ 0.05).Fig. 5.


In vivo measurement of dose distribution in patients' lymphocytes: helical tomotherapy versus step-and-shoot IMRT in prostate cancer.

Zwicker F, Swartman B, Roeder F, Sterzing F, Hauswald H, Thieke C, Weber KJ, Huber PE, Schubert K, Debus J, Herfarth K - J. Radiat. Res. (2014)

Analyses of dose–volume histograms (DVH) of patients' PTV prostate of the SSIMRT and the TOMO group (20 patients each): (a) mean relative dose maximum (D max) of the prescribed dose in the PTV prostate, and (b) mean relative volume (V) of PTV prostate that received dose more than 102% of the prescribed dose (D > 102%). Standard errors are shown.
© Copyright Policy - creative-commons
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4380044&req=5

RRU096F5: Analyses of dose–volume histograms (DVH) of patients' PTV prostate of the SSIMRT and the TOMO group (20 patients each): (a) mean relative dose maximum (D max) of the prescribed dose in the PTV prostate, and (b) mean relative volume (V) of PTV prostate that received dose more than 102% of the prescribed dose (D > 102%). Standard errors are shown.
Mentions: Analyses of dose–volume histograms of patients' PTVs (Fig. 5) for the two groups (SSIMRT and TOMO) showed the following results: the mean dose maximum (Dmax) of the prescribed dose in the PTV prostate was 107.8% (standard error: 0.389) in the SSIMRT group and 104.3% (standard error: 0.415) in the TOMO group. The difference was significant (P ≤ 0.05). The mean volume (V) of the prostate PTV that received a dose more than 102% of the prescribed dose (D > 102%) was 30.2% (standard error: 2.49; range: 8–47%) in the SSIMRT group and 4.57% (standard error: 0.61; range: 1–9%) in the TOMO group. This difference was also significant (P ≤ 0.05).Fig. 5.

Bottom Line: The isolated leukocytes were fixed 2 h after radiation.The dose exposure range, between 45 and 100%, was equal with both radiation techniques.Differences in the constructional buildup of the different linear accelerator systems, e.g. the flattening filter, may be the cause thereof.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiation Oncology, University of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany Clinical Cooperation Unit Radiation Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany f.zwicker@dkfz.de.

Show MeSH
Related in: MedlinePlus