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In vivo measurement of dose distribution in patients' lymphocytes: helical tomotherapy versus step-and-shoot IMRT in prostate cancer.

Zwicker F, Swartman B, Roeder F, Sterzing F, Hauswald H, Thieke C, Weber KJ, Huber PE, Schubert K, Debus J, Herfarth K - J. Radiat. Res. (2014)

Bottom Line: The dose exposure range, between 45 and 100%, was equal with both radiation techniques.In radiotherapy of the prostate gland, TOMO generates a smaller fraction of patients' lymphocytes with low-dose exposure relative to the whole body compared with SSIMRT.Differences in the constructional buildup of the different linear accelerator systems, e.g. the flattening filter, may be the cause thereof.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiation Oncology, University of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany Clinical Cooperation Unit Radiation Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany f.zwicker@dkfz.de.

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Analyses of dose–volume histograms (DVH) of patients' PTV prostate of the SSIMRT and the TOMO group (20 patients each): (a) mean relative dose maximum (D max) of the prescribed dose in the PTV prostate, and (b) mean relative volume (V) of PTV prostate that received dose more than 102% of the prescribed dose (D > 102%). Standard errors are shown.
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RRU096F5: Analyses of dose–volume histograms (DVH) of patients' PTV prostate of the SSIMRT and the TOMO group (20 patients each): (a) mean relative dose maximum (D max) of the prescribed dose in the PTV prostate, and (b) mean relative volume (V) of PTV prostate that received dose more than 102% of the prescribed dose (D > 102%). Standard errors are shown.

Mentions: Analyses of dose–volume histograms of patients' PTVs (Fig. 5) for the two groups (SSIMRT and TOMO) showed the following results: the mean dose maximum (Dmax) of the prescribed dose in the PTV prostate was 107.8% (standard error: 0.389) in the SSIMRT group and 104.3% (standard error: 0.415) in the TOMO group. The difference was significant (P ≤ 0.05). The mean volume (V) of the prostate PTV that received a dose more than 102% of the prescribed dose (D > 102%) was 30.2% (standard error: 2.49; range: 8–47%) in the SSIMRT group and 4.57% (standard error: 0.61; range: 1–9%) in the TOMO group. This difference was also significant (P ≤ 0.05).Fig. 5.


In vivo measurement of dose distribution in patients' lymphocytes: helical tomotherapy versus step-and-shoot IMRT in prostate cancer.

Zwicker F, Swartman B, Roeder F, Sterzing F, Hauswald H, Thieke C, Weber KJ, Huber PE, Schubert K, Debus J, Herfarth K - J. Radiat. Res. (2014)

Analyses of dose–volume histograms (DVH) of patients' PTV prostate of the SSIMRT and the TOMO group (20 patients each): (a) mean relative dose maximum (D max) of the prescribed dose in the PTV prostate, and (b) mean relative volume (V) of PTV prostate that received dose more than 102% of the prescribed dose (D > 102%). Standard errors are shown.
© Copyright Policy - creative-commons
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4380044&req=5

RRU096F5: Analyses of dose–volume histograms (DVH) of patients' PTV prostate of the SSIMRT and the TOMO group (20 patients each): (a) mean relative dose maximum (D max) of the prescribed dose in the PTV prostate, and (b) mean relative volume (V) of PTV prostate that received dose more than 102% of the prescribed dose (D > 102%). Standard errors are shown.
Mentions: Analyses of dose–volume histograms of patients' PTVs (Fig. 5) for the two groups (SSIMRT and TOMO) showed the following results: the mean dose maximum (Dmax) of the prescribed dose in the PTV prostate was 107.8% (standard error: 0.389) in the SSIMRT group and 104.3% (standard error: 0.415) in the TOMO group. The difference was significant (P ≤ 0.05). The mean volume (V) of the prostate PTV that received a dose more than 102% of the prescribed dose (D > 102%) was 30.2% (standard error: 2.49; range: 8–47%) in the SSIMRT group and 4.57% (standard error: 0.61; range: 1–9%) in the TOMO group. This difference was also significant (P ≤ 0.05).Fig. 5.

Bottom Line: The dose exposure range, between 45 and 100%, was equal with both radiation techniques.In radiotherapy of the prostate gland, TOMO generates a smaller fraction of patients' lymphocytes with low-dose exposure relative to the whole body compared with SSIMRT.Differences in the constructional buildup of the different linear accelerator systems, e.g. the flattening filter, may be the cause thereof.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiation Oncology, University of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany Clinical Cooperation Unit Radiation Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany f.zwicker@dkfz.de.

Show MeSH
Related in: MedlinePlus