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Whole-thorax irradiation induces hypoxic respiratory failure, pleural effusions and cardiac remodeling.

Medhora M, Gao F, Glisch C, Narayanan J, Sharma A, Harmann LM, Lawlor MW, Snyder LA, Fish BL, Down JD, Moulder JE, Strande JL, Jacobs ER - J. Radiat. Res. (2014)

Bottom Line: Lethal irradiation to rat lungs leads to hypoxia with infiltration of immune cells, edema and pleural effusion.These changes may contribute to pulmonary vascular and parenchymal injury that result in secondary changes in heart structure and function.We report that conditions resembling congestive heart failure contribute to death during radiation pneumonitis, which indicates new targets for therapy.

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Affiliation: Department of Radiation Oncology, Medical College of Wisconsin, 8701, Watertown Plank Road, Milwaukee, WI 53226, USA Cardiovascular Center, Medical College of Wisconsin, 8701, Watertown Plank Road, Milwaukee, WI 53226, USA Division of Pulmonary Medicine, Medical College of Wisconsin, 8701, Watertown Plank Road, Milwaukee, WI 53226, USA Research Service, Department of Veteran's Affairs, Clement J. Zablocki VA Medical Center, Milwaukee, Wisconsin, USA medhoram@mcw.edu.

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Histological findings in irradiated rat hearts. H&E stains of hearts taken at two magnifications from unirradiated (A and D) and irradiated (B, C, E and F) rats reveal scattered foci of lymphocytic inflammation in a subpopulation of irradiated rats. One irradiated rat showed cardiac myocyte necrosis (C and F, arrows) associated with lymphocytic inflammation. Bars = 80 μm (A, B and C) and 40 μm (D, E and F).
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RRU095F6: Histological findings in irradiated rat hearts. H&E stains of hearts taken at two magnifications from unirradiated (A and D) and irradiated (B, C, E and F) rats reveal scattered foci of lymphocytic inflammation in a subpopulation of irradiated rats. One irradiated rat showed cardiac myocyte necrosis (C and F, arrows) associated with lymphocytic inflammation. Bars = 80 μm (A, B and C) and 40 μm (D, E and F).

Mentions: No histological abnormalities were observed in H&E-stained sections of the heart from 4/10 irradiated rats or from any of the 6/6 hearts from unirradiated rats (Fig. 6). In 6/10 irradiated rats, we observed rare foci of chronic (lymphocytic) inflammation in the myocardium (Fig. 6B and E), usually constituting 10–20 lymphocytes surrounding a myocyte or blood vessel. These foci of inflammation were not reproducibly localized to a single ventricle or an area of the ventricular wall. In one animal, this inflammation was associated with a single focus of myocyte damage (Fig. 6C and F). The heart of one irradiated animal contained hemosiderin-laden macrophages surrounding small blood vessels in the myocardium (consistent with prior injury), but no other inflammation. Outside of these foci, there was no evidence of myocardial or vascular injury or fibrosis.Fig. 6.


Whole-thorax irradiation induces hypoxic respiratory failure, pleural effusions and cardiac remodeling.

Medhora M, Gao F, Glisch C, Narayanan J, Sharma A, Harmann LM, Lawlor MW, Snyder LA, Fish BL, Down JD, Moulder JE, Strande JL, Jacobs ER - J. Radiat. Res. (2014)

Histological findings in irradiated rat hearts. H&E stains of hearts taken at two magnifications from unirradiated (A and D) and irradiated (B, C, E and F) rats reveal scattered foci of lymphocytic inflammation in a subpopulation of irradiated rats. One irradiated rat showed cardiac myocyte necrosis (C and F, arrows) associated with lymphocytic inflammation. Bars = 80 μm (A, B and C) and 40 μm (D, E and F).
© Copyright Policy - creative-commons
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4380043&req=5

RRU095F6: Histological findings in irradiated rat hearts. H&E stains of hearts taken at two magnifications from unirradiated (A and D) and irradiated (B, C, E and F) rats reveal scattered foci of lymphocytic inflammation in a subpopulation of irradiated rats. One irradiated rat showed cardiac myocyte necrosis (C and F, arrows) associated with lymphocytic inflammation. Bars = 80 μm (A, B and C) and 40 μm (D, E and F).
Mentions: No histological abnormalities were observed in H&E-stained sections of the heart from 4/10 irradiated rats or from any of the 6/6 hearts from unirradiated rats (Fig. 6). In 6/10 irradiated rats, we observed rare foci of chronic (lymphocytic) inflammation in the myocardium (Fig. 6B and E), usually constituting 10–20 lymphocytes surrounding a myocyte or blood vessel. These foci of inflammation were not reproducibly localized to a single ventricle or an area of the ventricular wall. In one animal, this inflammation was associated with a single focus of myocyte damage (Fig. 6C and F). The heart of one irradiated animal contained hemosiderin-laden macrophages surrounding small blood vessels in the myocardium (consistent with prior injury), but no other inflammation. Outside of these foci, there was no evidence of myocardial or vascular injury or fibrosis.Fig. 6.

Bottom Line: Lethal irradiation to rat lungs leads to hypoxia with infiltration of immune cells, edema and pleural effusion.These changes may contribute to pulmonary vascular and parenchymal injury that result in secondary changes in heart structure and function.We report that conditions resembling congestive heart failure contribute to death during radiation pneumonitis, which indicates new targets for therapy.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiation Oncology, Medical College of Wisconsin, 8701, Watertown Plank Road, Milwaukee, WI 53226, USA Cardiovascular Center, Medical College of Wisconsin, 8701, Watertown Plank Road, Milwaukee, WI 53226, USA Division of Pulmonary Medicine, Medical College of Wisconsin, 8701, Watertown Plank Road, Milwaukee, WI 53226, USA Research Service, Department of Veteran's Affairs, Clement J. Zablocki VA Medical Center, Milwaukee, Wisconsin, USA medhoram@mcw.edu.

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Related in: MedlinePlus