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Whole-thorax irradiation induces hypoxic respiratory failure, pleural effusions and cardiac remodeling.

Medhora M, Gao F, Glisch C, Narayanan J, Sharma A, Harmann LM, Lawlor MW, Snyder LA, Fish BL, Down JD, Moulder JE, Strande JL, Jacobs ER - J. Radiat. Res. (2014)

Bottom Line: Lethal irradiation to rat lungs leads to hypoxia with infiltration of immune cells, edema and pleural effusion.These changes may contribute to pulmonary vascular and parenchymal injury that result in secondary changes in heart structure and function.We report that conditions resembling congestive heart failure contribute to death during radiation pneumonitis, which indicates new targets for therapy.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiation Oncology, Medical College of Wisconsin, 8701, Watertown Plank Road, Milwaukee, WI 53226, USA Cardiovascular Center, Medical College of Wisconsin, 8701, Watertown Plank Road, Milwaukee, WI 53226, USA Division of Pulmonary Medicine, Medical College of Wisconsin, 8701, Watertown Plank Road, Milwaukee, WI 53226, USA Research Service, Department of Veteran's Affairs, Clement J. Zablocki VA Medical Center, Milwaukee, Wisconsin, USA medhoram@mcw.edu.

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Radiation-induced decrease in body weight. Graph shows body weights (mean with standard deviation) of rats in grams at time of irradiation and 4 and 6 weeks after irradiation. Irradiated rats (15 Gy) had lower body weight than unirradiated control rats at 6 weeks (*P < 0.05). No difference was observed for results between the irradiation group and control at the other time-points. n = number of rats.
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RRU095F1: Radiation-induced decrease in body weight. Graph shows body weights (mean with standard deviation) of rats in grams at time of irradiation and 4 and 6 weeks after irradiation. Irradiated rats (15 Gy) had lower body weight than unirradiated control rats at 6 weeks (*P < 0.05). No difference was observed for results between the irradiation group and control at the other time-points. n = number of rats.

Mentions: All data are shown as means with standard deviations and number of animals, except for histology scores, which are medians with 25–75% ranges. For the multi-group comparisons in Figs 1–3, the significance of differences was assessed with ANOVA with the Holm-Sidak methods for dealing the multiple comparison issues. For the two-group comparisons in Tables 1 and 2 the significances of differences were determined by t-tests or by Mann–Whitney (the latter for histology scores).Table 2.


Whole-thorax irradiation induces hypoxic respiratory failure, pleural effusions and cardiac remodeling.

Medhora M, Gao F, Glisch C, Narayanan J, Sharma A, Harmann LM, Lawlor MW, Snyder LA, Fish BL, Down JD, Moulder JE, Strande JL, Jacobs ER - J. Radiat. Res. (2014)

Radiation-induced decrease in body weight. Graph shows body weights (mean with standard deviation) of rats in grams at time of irradiation and 4 and 6 weeks after irradiation. Irradiated rats (15 Gy) had lower body weight than unirradiated control rats at 6 weeks (*P < 0.05). No difference was observed for results between the irradiation group and control at the other time-points. n = number of rats.
© Copyright Policy - creative-commons
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4380043&req=5

RRU095F1: Radiation-induced decrease in body weight. Graph shows body weights (mean with standard deviation) of rats in grams at time of irradiation and 4 and 6 weeks after irradiation. Irradiated rats (15 Gy) had lower body weight than unirradiated control rats at 6 weeks (*P < 0.05). No difference was observed for results between the irradiation group and control at the other time-points. n = number of rats.
Mentions: All data are shown as means with standard deviations and number of animals, except for histology scores, which are medians with 25–75% ranges. For the multi-group comparisons in Figs 1–3, the significance of differences was assessed with ANOVA with the Holm-Sidak methods for dealing the multiple comparison issues. For the two-group comparisons in Tables 1 and 2 the significances of differences were determined by t-tests or by Mann–Whitney (the latter for histology scores).Table 2.

Bottom Line: Lethal irradiation to rat lungs leads to hypoxia with infiltration of immune cells, edema and pleural effusion.These changes may contribute to pulmonary vascular and parenchymal injury that result in secondary changes in heart structure and function.We report that conditions resembling congestive heart failure contribute to death during radiation pneumonitis, which indicates new targets for therapy.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiation Oncology, Medical College of Wisconsin, 8701, Watertown Plank Road, Milwaukee, WI 53226, USA Cardiovascular Center, Medical College of Wisconsin, 8701, Watertown Plank Road, Milwaukee, WI 53226, USA Division of Pulmonary Medicine, Medical College of Wisconsin, 8701, Watertown Plank Road, Milwaukee, WI 53226, USA Research Service, Department of Veteran's Affairs, Clement J. Zablocki VA Medical Center, Milwaukee, Wisconsin, USA medhoram@mcw.edu.

Show MeSH
Related in: MedlinePlus