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Dose-response relationship between serum 2,3,7,8-tetrachlorodibenzo-p-dioxin and diabetes mellitus: a meta-analysis.

Goodman M, Narayan KM, Flanders D, Chang ET, Adami HO, Boffetta P, Mandel JS - Am. J. Epidemiol. (2015)

Bottom Line: Regression slopes for each dependent variable were obtained for each study and included in a random-effects meta-analysis.None of the summary estimates in the main models or in the sensitivity analyses indicated a statistically significant association.Considering the discrepancy of results for low current versus high past TCDD levels, the available data do not indicate that increasing TCDD exposure is associated with an increased risk of DM.

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Results of a meta-regression for natural log-transformed relative risk estimate (ln(RR)) (y-axis) by maximum difference between the highest and the lowest levels of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (x-axis). In the main analysis, in which we used data from Steenland et al. (34) (National Institute of Occupational Safety and Health cohort), Zober et al. (35), Steenland et al. (34) (Operation Ranch Hand cohort), Warner et al. (24), Kim et al. (39), Longnecker and Michalek (40), Kang et al. (38), and Nakamoto et al. (25), β = −0.00018 (95% confidence interval (CI): −0.00107, 0.00072; P = 0.643). In the sensitivity analysis in which Steenland et al. (34) Operation Ranch Hand cohort data were replaced with data from Henriksen et al. (12), β = −0.00026 (95% CI: −0.00117, 0.00065; P = 0.515). In the sensitivity analysis in which Steenland et al. (34) Operation Ranch Hand cohort data were replaced with data from the US Air Force (37), β = −0.00027 (95% CI: −0.00115, 0.00060; P = 0.476). In the sensitivity analysis in which within-study analyses were replaced with results using an external reference group (if available), β = −0.00020 (95% CI: −0.00084, 0.00044; P = 0.456). This analysis was limited to 7 observations because participants from the study by Longnecker and Michalek (40) served as an external comparison group for the Operation Ranch Hand cohort.
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KWU307F2: Results of a meta-regression for natural log-transformed relative risk estimate (ln(RR)) (y-axis) by maximum difference between the highest and the lowest levels of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (x-axis). In the main analysis, in which we used data from Steenland et al. (34) (National Institute of Occupational Safety and Health cohort), Zober et al. (35), Steenland et al. (34) (Operation Ranch Hand cohort), Warner et al. (24), Kim et al. (39), Longnecker and Michalek (40), Kang et al. (38), and Nakamoto et al. (25), β = −0.00018 (95% confidence interval (CI): −0.00107, 0.00072; P = 0.643). In the sensitivity analysis in which Steenland et al. (34) Operation Ranch Hand cohort data were replaced with data from Henriksen et al. (12), β = −0.00026 (95% CI: −0.00117, 0.00065; P = 0.515). In the sensitivity analysis in which Steenland et al. (34) Operation Ranch Hand cohort data were replaced with data from the US Air Force (37), β = −0.00027 (95% CI: −0.00115, 0.00060; P = 0.476). In the sensitivity analysis in which within-study analyses were replaced with results using an external reference group (if available), β = −0.00020 (95% CI: −0.00084, 0.00044; P = 0.456). This analysis was limited to 7 observations because participants from the study by Longnecker and Michalek (40) served as an external comparison group for the Operation Ranch Hand cohort.

Mentions: The relationship of the maximum difference between TCDD concentrations in the highest versus the lowest exposure category with the corresponding difference in P(DM) is shown in Figure 1. The resulting regression slope was not statistically significantly different from the value (β = −0.00004; 95% confidence interval (CI): −0.00012, 0.00004; P = 0.31). In the corresponding analyses with ln(RR) as the outcome (Figure 2), the summary regression coefficient was also not statistically significant (β = −0.00018; 95% CI: −0.00107, 0.00072; P = 0.64). The results of sensitivity analyses did not materially affect the direction or the precision of the original estimates (Figures 1 and 2).Figure 1.


Dose-response relationship between serum 2,3,7,8-tetrachlorodibenzo-p-dioxin and diabetes mellitus: a meta-analysis.

Goodman M, Narayan KM, Flanders D, Chang ET, Adami HO, Boffetta P, Mandel JS - Am. J. Epidemiol. (2015)

Results of a meta-regression for natural log-transformed relative risk estimate (ln(RR)) (y-axis) by maximum difference between the highest and the lowest levels of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (x-axis). In the main analysis, in which we used data from Steenland et al. (34) (National Institute of Occupational Safety and Health cohort), Zober et al. (35), Steenland et al. (34) (Operation Ranch Hand cohort), Warner et al. (24), Kim et al. (39), Longnecker and Michalek (40), Kang et al. (38), and Nakamoto et al. (25), β = −0.00018 (95% confidence interval (CI): −0.00107, 0.00072; P = 0.643). In the sensitivity analysis in which Steenland et al. (34) Operation Ranch Hand cohort data were replaced with data from Henriksen et al. (12), β = −0.00026 (95% CI: −0.00117, 0.00065; P = 0.515). In the sensitivity analysis in which Steenland et al. (34) Operation Ranch Hand cohort data were replaced with data from the US Air Force (37), β = −0.00027 (95% CI: −0.00115, 0.00060; P = 0.476). In the sensitivity analysis in which within-study analyses were replaced with results using an external reference group (if available), β = −0.00020 (95% CI: −0.00084, 0.00044; P = 0.456). This analysis was limited to 7 observations because participants from the study by Longnecker and Michalek (40) served as an external comparison group for the Operation Ranch Hand cohort.
© Copyright Policy - creative-commons
Related In: Results  -  Collection

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Show All Figures
getmorefigures.php?uid=PMC4380020&req=5

KWU307F2: Results of a meta-regression for natural log-transformed relative risk estimate (ln(RR)) (y-axis) by maximum difference between the highest and the lowest levels of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (x-axis). In the main analysis, in which we used data from Steenland et al. (34) (National Institute of Occupational Safety and Health cohort), Zober et al. (35), Steenland et al. (34) (Operation Ranch Hand cohort), Warner et al. (24), Kim et al. (39), Longnecker and Michalek (40), Kang et al. (38), and Nakamoto et al. (25), β = −0.00018 (95% confidence interval (CI): −0.00107, 0.00072; P = 0.643). In the sensitivity analysis in which Steenland et al. (34) Operation Ranch Hand cohort data were replaced with data from Henriksen et al. (12), β = −0.00026 (95% CI: −0.00117, 0.00065; P = 0.515). In the sensitivity analysis in which Steenland et al. (34) Operation Ranch Hand cohort data were replaced with data from the US Air Force (37), β = −0.00027 (95% CI: −0.00115, 0.00060; P = 0.476). In the sensitivity analysis in which within-study analyses were replaced with results using an external reference group (if available), β = −0.00020 (95% CI: −0.00084, 0.00044; P = 0.456). This analysis was limited to 7 observations because participants from the study by Longnecker and Michalek (40) served as an external comparison group for the Operation Ranch Hand cohort.
Mentions: The relationship of the maximum difference between TCDD concentrations in the highest versus the lowest exposure category with the corresponding difference in P(DM) is shown in Figure 1. The resulting regression slope was not statistically significantly different from the value (β = −0.00004; 95% confidence interval (CI): −0.00012, 0.00004; P = 0.31). In the corresponding analyses with ln(RR) as the outcome (Figure 2), the summary regression coefficient was also not statistically significant (β = −0.00018; 95% CI: −0.00107, 0.00072; P = 0.64). The results of sensitivity analyses did not materially affect the direction or the precision of the original estimates (Figures 1 and 2).Figure 1.

Bottom Line: Regression slopes for each dependent variable were obtained for each study and included in a random-effects meta-analysis.None of the summary estimates in the main models or in the sensitivity analyses indicated a statistically significant association.Considering the discrepancy of results for low current versus high past TCDD levels, the available data do not indicate that increasing TCDD exposure is associated with an increased risk of DM.

View Article: PubMed Central - PubMed

Show MeSH
Related in: MedlinePlus