Dose-response relationship between serum 2,3,7,8-tetrachlorodibenzo-p-dioxin and diabetes mellitus: a meta-analysis.
Bottom Line: None of the summary estimates in the main models or in the sensitivity analyses indicated a statistically significant association.We found a pronounced dichotomy: a positive dose-response in cross-sectional studies of populations with low-level TCDD exposures (serum concentrations <10 pg/g lipid) and heterogeneous, but on balance , results for prospective studies of persons with high prediagnosis TCDD body burdens.Considering the discrepancy of results for low current versus high past TCDD levels, the available data do not indicate that increasing TCDD exposure is associated with an increased risk of DM.
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Mentions: The relationship of the maximum difference between TCDD concentrations in the highest versus the lowest exposure category with the corresponding difference in P(DM) is shown in Figure 1. The resulting regression slope was not statistically significantly different from the value (β = −0.00004; 95% confidence interval (CI): −0.00012, 0.00004; P = 0.31). In the corresponding analyses with ln(RR) as the outcome (Figure 2), the summary regression coefficient was also not statistically significant (β = −0.00018; 95% CI: −0.00107, 0.00072; P = 0.64). The results of sensitivity analyses did not materially affect the direction or the precision of the original estimates (Figures 1 and 2).Figure 1.