Dose-response relationship between serum 2,3,7,8-tetrachlorodibenzo-p-dioxin and diabetes mellitus: a meta-analysis.
Bottom Line: Regression slopes for each dependent variable were obtained for each study and included in a random-effects meta-analysis.None of the summary estimates in the main models or in the sensitivity analyses indicated a statistically significant association.Considering the discrepancy of results for low current versus high past TCDD levels, the available data do not indicate that increasing TCDD exposure is associated with an increased risk of DM.
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Mentions: The relationship of the maximum difference between TCDD concentrations in the highest versus the lowest exposure category with the corresponding difference in P(DM) is shown in Figure 1. The resulting regression slope was not statistically significantly different from the value (β = −0.00004; 95% confidence interval (CI): −0.00012, 0.00004; P = 0.31). In the corresponding analyses with ln(RR) as the outcome (Figure 2), the summary regression coefficient was also not statistically significant (β = −0.00018; 95% CI: −0.00107, 0.00072; P = 0.64). The results of sensitivity analyses did not materially affect the direction or the precision of the original estimates (Figures 1 and 2).Figure 1.