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Hair Regeneration Treatment Using Adipose-Derived Stem Cell Conditioned Medium: Follow-up With Trichograms.

Fukuoka H, Suga H - Eplasty (2015)

Bottom Line: Hair numbers were significantly increased after treatment in both male (including those without finasteride administration) and female patients.In the half-side comparison study, the increase in hair numbers was significantly higher on the treatment side than on the placebo side.Treatment using adipose-derived stem cell-conditioned medium appears highly effective for alopecia and may represent a new therapy for hair regeneration.

View Article: PubMed Central - PubMed

Affiliation: Cherry-Blossom Plastic and Regenerative Surgery, Tokyo, Japan; and Department of Plastic and Reconstructive Surgery, Kyorin University, Tokyo, Japan.

ABSTRACT

Objective: Adipose-derived stem cells secrete various growth factors that promote hair growth. This study examined the effects of adipose-derived stem cell-conditioned medium on alopecia.

Methods: Adipose-derived stem cell-conditioned medium was intradermally injected in 22 patients (11 men and 11 women) with alopecia. Patients received treatment every 3 to 5 weeks for a total of 6 sessions. Hair numbers were counted using trichograms before and after treatment. A half-side comparison study was also performed in 10 patients (8 men and 2 women).

Results: Hair numbers were significantly increased after treatment in both male (including those without finasteride administration) and female patients. In the half-side comparison study, the increase in hair numbers was significantly higher on the treatment side than on the placebo side.

Conclusion: Treatment using adipose-derived stem cell-conditioned medium appears highly effective for alopecia and may represent a new therapy for hair regeneration.

No MeSH data available.


Changes in the number of hairs before and after treatment in male patients with or without finasteride administration. *P < .05.
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Figure 3: Changes in the number of hairs before and after treatment in male patients with or without finasteride administration. *P < .05.

Mentions: Numbers of hairs in the same area of the same patient were accurately counted using trichograms before and after treatment (Fig 1). The number of hairs increased significantly after treatment in both male (n = 11) and female (n = 11) patients (Fig 2). The mean increase in the number of hairs was 29 ± 4.1 in male patients and 15.6 ± 4.2 in female patients. No significant difference was observed between men and women. In male patients, groups with (n = 6) and without (n = 5) finasteride administration were compared. The number of hairs increased significantly after treatment in both groups (Fig 3). No significant difference was observed between groups with or without finasteride administration. Representative clinical courses are shown in Figure 4 (a male patient) and Figure 5 (a female patient).


Hair Regeneration Treatment Using Adipose-Derived Stem Cell Conditioned Medium: Follow-up With Trichograms.

Fukuoka H, Suga H - Eplasty (2015)

Changes in the number of hairs before and after treatment in male patients with or without finasteride administration. *P < .05.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4379938&req=5

Figure 3: Changes in the number of hairs before and after treatment in male patients with or without finasteride administration. *P < .05.
Mentions: Numbers of hairs in the same area of the same patient were accurately counted using trichograms before and after treatment (Fig 1). The number of hairs increased significantly after treatment in both male (n = 11) and female (n = 11) patients (Fig 2). The mean increase in the number of hairs was 29 ± 4.1 in male patients and 15.6 ± 4.2 in female patients. No significant difference was observed between men and women. In male patients, groups with (n = 6) and without (n = 5) finasteride administration were compared. The number of hairs increased significantly after treatment in both groups (Fig 3). No significant difference was observed between groups with or without finasteride administration. Representative clinical courses are shown in Figure 4 (a male patient) and Figure 5 (a female patient).

Bottom Line: Hair numbers were significantly increased after treatment in both male (including those without finasteride administration) and female patients.In the half-side comparison study, the increase in hair numbers was significantly higher on the treatment side than on the placebo side.Treatment using adipose-derived stem cell-conditioned medium appears highly effective for alopecia and may represent a new therapy for hair regeneration.

View Article: PubMed Central - PubMed

Affiliation: Cherry-Blossom Plastic and Regenerative Surgery, Tokyo, Japan; and Department of Plastic and Reconstructive Surgery, Kyorin University, Tokyo, Japan.

ABSTRACT

Objective: Adipose-derived stem cells secrete various growth factors that promote hair growth. This study examined the effects of adipose-derived stem cell-conditioned medium on alopecia.

Methods: Adipose-derived stem cell-conditioned medium was intradermally injected in 22 patients (11 men and 11 women) with alopecia. Patients received treatment every 3 to 5 weeks for a total of 6 sessions. Hair numbers were counted using trichograms before and after treatment. A half-side comparison study was also performed in 10 patients (8 men and 2 women).

Results: Hair numbers were significantly increased after treatment in both male (including those without finasteride administration) and female patients. In the half-side comparison study, the increase in hair numbers was significantly higher on the treatment side than on the placebo side.

Conclusion: Treatment using adipose-derived stem cell-conditioned medium appears highly effective for alopecia and may represent a new therapy for hair regeneration.

No MeSH data available.