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Yes, there is a medial nucleus of the trapezoid body in humans.

Kulesza RJ, Grothe B - Front Neuroanat (2015)

Bottom Line: MNTB neurons are associated with a number of anatomical and physiological specializations which make these cells especially well-equipped to provide extremely fast and precise glycinergic inhibition to its target neurons in the superior olivary complex and ventral nucleus of the lateral lemniscus.However, a number of recent studies of human post-mortem tissue have provided evidence supporting the existence of the MNTB in humans.It therefore seems timely to review the structure and function of the MNTB, critically review the literature which led to the denial of the human MNTB and then review recent investigations supporting the existence of the MNTB in the human brain.

View Article: PubMed Central - PubMed

Affiliation: Department of Anatomy, Auditory Research Center, Lake Erie College of Osteopathic Medicine Erie, PA, USA.

ABSTRACT
The medial nucleus of the trapezoid body (MNTB) is a collection of brainstem neurons that function within the ascending auditory pathway. MNTB neurons are associated with a number of anatomical and physiological specializations which make these cells especially well-equipped to provide extremely fast and precise glycinergic inhibition to its target neurons in the superior olivary complex and ventral nucleus of the lateral lemniscus. The inhibitory influence of MNTB neurons plays essentials roles in the localization of sound sources and encoding temporal features of complex sounds. The morphology, afferent and efferent connections and physiological response properties of MNTB neurons have been well-characterized in a number of laboratory rodents and some carnivores. Furthermore, the MNTB has been positively identified in all mammals examined, ranging from opossum and mice to chimpanzees. From the early 1970s through 2009, a number of studies denied the existence of the MNTB in humans and consequentially, the existence of this nucleus in the human brain has been debated for nearly 50 years. The absence of the MNTB from the human brain would negate current principles of sound localization and would require a number of novel adaptations, entirely unique to humans. However, a number of recent studies of human post-mortem tissue have provided evidence supporting the existence of the MNTB in humans. It therefore seems timely to review the structure and function of the MNTB, critically review the literature which led to the denial of the human MNTB and then review recent investigations supporting the existence of the MNTB in the human brain.

No MeSH data available.


Related in: MedlinePlus

Circuitry of the human MNTB. The figure illustrates the nuclei that make up the human SOC and the connections of MNTB neurons. The MNTB is situated ventral (anterior) and medial to the MSO and receives its main excitatory input from the contralateral cochlear nucleus via GBCs and the calyx of Held (green line). MNTB neurons characteristically express calbindin, the Kv3.1b potassium channel and MNTB somata are associated with perineuronal nets (blue). The MNTB provides topographic, glycinergic projections to the SPON, MSO, LSO, and VNLL.
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Figure 1: Circuitry of the human MNTB. The figure illustrates the nuclei that make up the human SOC and the connections of MNTB neurons. The MNTB is situated ventral (anterior) and medial to the MSO and receives its main excitatory input from the contralateral cochlear nucleus via GBCs and the calyx of Held (green line). MNTB neurons characteristically express calbindin, the Kv3.1b potassium channel and MNTB somata are associated with perineuronal nets (blue). The MNTB provides topographic, glycinergic projections to the SPON, MSO, LSO, and VNLL.

Mentions: The MNTB is not the only group of neurons providing inhibition to the SOC, an important mammalian auditory brainstem center, but it is the most prominent. Principal neurons of the MNTB receive their main excitatory input from GBCs in the contralateral ventral cochlear nucleus. The GBC-MNTB pathway exhibits a number of extraordinary specialized anatomical and physiological features related to fast and high-fidelity processing of temporal information, the calyx of Held being the most prominent one. The GBCs and calyx terminals are characteristically CR (Figure 1; Arai et al., 1991; Resibois and Rogers, 1992; Lohmann and Friauf, 1996; Bazwinsky et al., 2005), Rab3a and VGLUT1 positive (Felmy and Schneggenburger, 2004). The principal neurons of the MNTB are distinctively CB-IR and perineuronal nets are known to ensheath the soma and primary dendrites of these neurons (Figure 1; Härtig et al., 2001; Hilbig et al., 2007; Schmidt et al., 2010; Blosa et al., 2013) and MNTB neurons are known to specifically express the Kv3.1b potassium channel (Wang et al., 1998).


Yes, there is a medial nucleus of the trapezoid body in humans.

Kulesza RJ, Grothe B - Front Neuroanat (2015)

Circuitry of the human MNTB. The figure illustrates the nuclei that make up the human SOC and the connections of MNTB neurons. The MNTB is situated ventral (anterior) and medial to the MSO and receives its main excitatory input from the contralateral cochlear nucleus via GBCs and the calyx of Held (green line). MNTB neurons characteristically express calbindin, the Kv3.1b potassium channel and MNTB somata are associated with perineuronal nets (blue). The MNTB provides topographic, glycinergic projections to the SPON, MSO, LSO, and VNLL.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4379933&req=5

Figure 1: Circuitry of the human MNTB. The figure illustrates the nuclei that make up the human SOC and the connections of MNTB neurons. The MNTB is situated ventral (anterior) and medial to the MSO and receives its main excitatory input from the contralateral cochlear nucleus via GBCs and the calyx of Held (green line). MNTB neurons characteristically express calbindin, the Kv3.1b potassium channel and MNTB somata are associated with perineuronal nets (blue). The MNTB provides topographic, glycinergic projections to the SPON, MSO, LSO, and VNLL.
Mentions: The MNTB is not the only group of neurons providing inhibition to the SOC, an important mammalian auditory brainstem center, but it is the most prominent. Principal neurons of the MNTB receive their main excitatory input from GBCs in the contralateral ventral cochlear nucleus. The GBC-MNTB pathway exhibits a number of extraordinary specialized anatomical and physiological features related to fast and high-fidelity processing of temporal information, the calyx of Held being the most prominent one. The GBCs and calyx terminals are characteristically CR (Figure 1; Arai et al., 1991; Resibois and Rogers, 1992; Lohmann and Friauf, 1996; Bazwinsky et al., 2005), Rab3a and VGLUT1 positive (Felmy and Schneggenburger, 2004). The principal neurons of the MNTB are distinctively CB-IR and perineuronal nets are known to ensheath the soma and primary dendrites of these neurons (Figure 1; Härtig et al., 2001; Hilbig et al., 2007; Schmidt et al., 2010; Blosa et al., 2013) and MNTB neurons are known to specifically express the Kv3.1b potassium channel (Wang et al., 1998).

Bottom Line: MNTB neurons are associated with a number of anatomical and physiological specializations which make these cells especially well-equipped to provide extremely fast and precise glycinergic inhibition to its target neurons in the superior olivary complex and ventral nucleus of the lateral lemniscus.However, a number of recent studies of human post-mortem tissue have provided evidence supporting the existence of the MNTB in humans.It therefore seems timely to review the structure and function of the MNTB, critically review the literature which led to the denial of the human MNTB and then review recent investigations supporting the existence of the MNTB in the human brain.

View Article: PubMed Central - PubMed

Affiliation: Department of Anatomy, Auditory Research Center, Lake Erie College of Osteopathic Medicine Erie, PA, USA.

ABSTRACT
The medial nucleus of the trapezoid body (MNTB) is a collection of brainstem neurons that function within the ascending auditory pathway. MNTB neurons are associated with a number of anatomical and physiological specializations which make these cells especially well-equipped to provide extremely fast and precise glycinergic inhibition to its target neurons in the superior olivary complex and ventral nucleus of the lateral lemniscus. The inhibitory influence of MNTB neurons plays essentials roles in the localization of sound sources and encoding temporal features of complex sounds. The morphology, afferent and efferent connections and physiological response properties of MNTB neurons have been well-characterized in a number of laboratory rodents and some carnivores. Furthermore, the MNTB has been positively identified in all mammals examined, ranging from opossum and mice to chimpanzees. From the early 1970s through 2009, a number of studies denied the existence of the MNTB in humans and consequentially, the existence of this nucleus in the human brain has been debated for nearly 50 years. The absence of the MNTB from the human brain would negate current principles of sound localization and would require a number of novel adaptations, entirely unique to humans. However, a number of recent studies of human post-mortem tissue have provided evidence supporting the existence of the MNTB in humans. It therefore seems timely to review the structure and function of the MNTB, critically review the literature which led to the denial of the human MNTB and then review recent investigations supporting the existence of the MNTB in the human brain.

No MeSH data available.


Related in: MedlinePlus