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Unusual sites of metastatic recurrence of osteosarcoma detected on fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography.

Kabnurkar R, Agrawal A, Rekhi B, Purandare N, Shah S, Rangarajan V - Indian J Nucl Med (2015 Apr-Jun)

Bottom Line: Osteosarcoma (OS) is the most common nonhematolymphoid primary bone malignancy characterized by osteoid or new bone formation.Lungs and bones are the most common sites of metastases.We report a case where unusual sites of the soft tissue recurrence from OS were detected on restaging fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography scan done post 6 years of disease free interval.

View Article: PubMed Central - PubMed

Affiliation: Department of Nuclear Medicine and Molecular Imaging, Tata Memorial Hospital, Parel, Mumbai, Maharashtra, India.

ABSTRACT
Osteosarcoma (OS) is the most common nonhematolymphoid primary bone malignancy characterized by osteoid or new bone formation. Lungs and bones are the most common sites of metastases. We report a case where unusual sites of the soft tissue recurrence from OS were detected on restaging fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography scan done post 6 years of disease free interval.

No MeSH data available.


Related in: MedlinePlus

Fine-needle aspiration cytology of the anterior abdominal wall lump - H and E stained slides revealed hypercellular smear showing markedly pleomorphic/ sarcomatous cells including giant cells amidst stroma consistent with osteogenic sarcoma (×200). Insert: A large sarcomatous cell with a pleomorphic nucleus and moderate cytoplasm (×100)
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Figure 1: Fine-needle aspiration cytology of the anterior abdominal wall lump - H and E stained slides revealed hypercellular smear showing markedly pleomorphic/ sarcomatous cells including giant cells amidst stroma consistent with osteogenic sarcoma (×200). Insert: A large sarcomatous cell with a pleomorphic nucleus and moderate cytoplasm (×100)

Mentions: A 26-year-old young gentleman, a diagnosed case of OS of right femur was treated with neoadjuvant chemotherapy followed by wide excision of the mass with prosthesis insertion. Histopathology revealed no residual viable tumor (100% necrosis). Proximal and distal bony and soft tissue cut margins were free of tumor. The patient had a disease free interval of 6 years following which he presented with a lump over the anterior abdominal wall. Fine-needle aspiration cytology of the lump was suggestive of disease recurrence [Figure 1]. Restaging F-18 FDG PET/CT revealed metastatic deposit in right paraspinal muscle at the level of C1 vertebra, muscle deposit in right arm, subcutaneous nodules in anterior abdominal wall, right lateral chest wall, left arm, serosal deposit over ascending colon and pancreatic deposit in addition to the pulmonary and bone metastases. No evidence of active disease was noted in the periprosthetic region at the operated site [Figure 2]. The patient was started on metronomic chemotherapy.


Unusual sites of metastatic recurrence of osteosarcoma detected on fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography.

Kabnurkar R, Agrawal A, Rekhi B, Purandare N, Shah S, Rangarajan V - Indian J Nucl Med (2015 Apr-Jun)

Fine-needle aspiration cytology of the anterior abdominal wall lump - H and E stained slides revealed hypercellular smear showing markedly pleomorphic/ sarcomatous cells including giant cells amidst stroma consistent with osteogenic sarcoma (×200). Insert: A large sarcomatous cell with a pleomorphic nucleus and moderate cytoplasm (×100)
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4379683&req=5

Figure 1: Fine-needle aspiration cytology of the anterior abdominal wall lump - H and E stained slides revealed hypercellular smear showing markedly pleomorphic/ sarcomatous cells including giant cells amidst stroma consistent with osteogenic sarcoma (×200). Insert: A large sarcomatous cell with a pleomorphic nucleus and moderate cytoplasm (×100)
Mentions: A 26-year-old young gentleman, a diagnosed case of OS of right femur was treated with neoadjuvant chemotherapy followed by wide excision of the mass with prosthesis insertion. Histopathology revealed no residual viable tumor (100% necrosis). Proximal and distal bony and soft tissue cut margins were free of tumor. The patient had a disease free interval of 6 years following which he presented with a lump over the anterior abdominal wall. Fine-needle aspiration cytology of the lump was suggestive of disease recurrence [Figure 1]. Restaging F-18 FDG PET/CT revealed metastatic deposit in right paraspinal muscle at the level of C1 vertebra, muscle deposit in right arm, subcutaneous nodules in anterior abdominal wall, right lateral chest wall, left arm, serosal deposit over ascending colon and pancreatic deposit in addition to the pulmonary and bone metastases. No evidence of active disease was noted in the periprosthetic region at the operated site [Figure 2]. The patient was started on metronomic chemotherapy.

Bottom Line: Osteosarcoma (OS) is the most common nonhematolymphoid primary bone malignancy characterized by osteoid or new bone formation.Lungs and bones are the most common sites of metastases.We report a case where unusual sites of the soft tissue recurrence from OS were detected on restaging fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography scan done post 6 years of disease free interval.

View Article: PubMed Central - PubMed

Affiliation: Department of Nuclear Medicine and Molecular Imaging, Tata Memorial Hospital, Parel, Mumbai, Maharashtra, India.

ABSTRACT
Osteosarcoma (OS) is the most common nonhematolymphoid primary bone malignancy characterized by osteoid or new bone formation. Lungs and bones are the most common sites of metastases. We report a case where unusual sites of the soft tissue recurrence from OS were detected on restaging fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography scan done post 6 years of disease free interval.

No MeSH data available.


Related in: MedlinePlus