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Fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography in the detection of primary pulmonary angiosarcomas.

Krishnamurthy A, Nayak D, Ramshankar V, Majhi U - Indian J Nucl Med (2015 Apr-Jun)

Bottom Line: Pulmonary angiosarcomas are invariably (>90%) metastatic tumors form primaries of the skin, bone, liver, breast, or heart.Primary pulmonary angiosarcomas are exceedingly rare, with just about 20 cases being reported in the literature.We report an additional case with a brief review of the literature of a primary pulmonary angiosarcoma in a 26-year-old lady who presented with intractable hemoptysis.

View Article: PubMed Central - PubMed

Affiliation: Department of Surgical Oncology, Cancer Institute (WIA), Adyar, Chennai, Tamil Nadu, India.

ABSTRACT
Angiosarcoma is a malignant vascular tumor that originates from the mesenchymal cells which have undergone angioblastic differentiation. Pulmonary angiosarcomas are invariably (>90%) metastatic tumors form primaries of the skin, bone, liver, breast, or heart. Primary pulmonary angiosarcomas are exceedingly rare, with just about 20 cases being reported in the literature. We report an additional case with a brief review of the literature of a primary pulmonary angiosarcoma in a 26-year-old lady who presented with intractable hemoptysis. In addition, we highlight the potential of fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography as an important diagnostic tool in the evaluation of this tumor and thus contribute to the existing sparse literature on this fascinating yet devastating disease.

No MeSH data available.


Related in: MedlinePlus

(a-c) An fluorine-18 fluorodeoxyglucose positron emission tomography/ computed tomography revealed a solitary metabolically active endobronchial lesion measuring 3.5 cm × 1.8 cm (SUVmax-9.3) in the left main bronchus extending into the left lower bronchus causing complete obstruction and collapse of the entire left lung
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Figure 2: (a-c) An fluorine-18 fluorodeoxyglucose positron emission tomography/ computed tomography revealed a solitary metabolically active endobronchial lesion measuring 3.5 cm × 1.8 cm (SUVmax-9.3) in the left main bronchus extending into the left lower bronchus causing complete obstruction and collapse of the entire left lung

Mentions: A 26-year-old lady with no comorbid conditions, presented with a 2 months history of cough and intractable hemoptysis. A bronchoscopic examination performed in another hospital revealed a vascular fleshy growth protruding onto the left main bronchus, and an attempted biopsy resulted in profuse bleeding. The procedure was, therefore, abandoned, and the patient was referred to our center for further management. A repeat bronchoscopy performed at our center confirmed the previous bronchoscopy findings, additionally the tumor was found to completely occlude the left main bronchus. A biopsy from the lesion resulted in profuse bleeding and was managed conservatively. Histology with immunohistochemistry (IHC) correlation suggested a diagnosis of a primary pulmonary angiosarcoma, intermediate grade. The tumor cells were immunopositive for vimentin, smooth muscle actin, CD31 and CD34, negative for keratin, desmin and myoglobulin. Thirty percentage of the tumor cells showed nuclear positivity to Ki-67 [Figure 1a-d]. An fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) done as a part of the metastatic work up revealed a solitary metabolically active endobronchial lesion measuring 3.5 cm × 1.8 cm (SUVmax-9.3) in the left main bronchus extending into the left lower bronchus causing complete obstruction and collapse of the entire left lung; further corroborating the diagnosis of a primary pulmonary angiosarcoma [Figure 2a-c].


Fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography in the detection of primary pulmonary angiosarcomas.

Krishnamurthy A, Nayak D, Ramshankar V, Majhi U - Indian J Nucl Med (2015 Apr-Jun)

(a-c) An fluorine-18 fluorodeoxyglucose positron emission tomography/ computed tomography revealed a solitary metabolically active endobronchial lesion measuring 3.5 cm × 1.8 cm (SUVmax-9.3) in the left main bronchus extending into the left lower bronchus causing complete obstruction and collapse of the entire left lung
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4379674&req=5

Figure 2: (a-c) An fluorine-18 fluorodeoxyglucose positron emission tomography/ computed tomography revealed a solitary metabolically active endobronchial lesion measuring 3.5 cm × 1.8 cm (SUVmax-9.3) in the left main bronchus extending into the left lower bronchus causing complete obstruction and collapse of the entire left lung
Mentions: A 26-year-old lady with no comorbid conditions, presented with a 2 months history of cough and intractable hemoptysis. A bronchoscopic examination performed in another hospital revealed a vascular fleshy growth protruding onto the left main bronchus, and an attempted biopsy resulted in profuse bleeding. The procedure was, therefore, abandoned, and the patient was referred to our center for further management. A repeat bronchoscopy performed at our center confirmed the previous bronchoscopy findings, additionally the tumor was found to completely occlude the left main bronchus. A biopsy from the lesion resulted in profuse bleeding and was managed conservatively. Histology with immunohistochemistry (IHC) correlation suggested a diagnosis of a primary pulmonary angiosarcoma, intermediate grade. The tumor cells were immunopositive for vimentin, smooth muscle actin, CD31 and CD34, negative for keratin, desmin and myoglobulin. Thirty percentage of the tumor cells showed nuclear positivity to Ki-67 [Figure 1a-d]. An fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) done as a part of the metastatic work up revealed a solitary metabolically active endobronchial lesion measuring 3.5 cm × 1.8 cm (SUVmax-9.3) in the left main bronchus extending into the left lower bronchus causing complete obstruction and collapse of the entire left lung; further corroborating the diagnosis of a primary pulmonary angiosarcoma [Figure 2a-c].

Bottom Line: Pulmonary angiosarcomas are invariably (>90%) metastatic tumors form primaries of the skin, bone, liver, breast, or heart.Primary pulmonary angiosarcomas are exceedingly rare, with just about 20 cases being reported in the literature.We report an additional case with a brief review of the literature of a primary pulmonary angiosarcoma in a 26-year-old lady who presented with intractable hemoptysis.

View Article: PubMed Central - PubMed

Affiliation: Department of Surgical Oncology, Cancer Institute (WIA), Adyar, Chennai, Tamil Nadu, India.

ABSTRACT
Angiosarcoma is a malignant vascular tumor that originates from the mesenchymal cells which have undergone angioblastic differentiation. Pulmonary angiosarcomas are invariably (>90%) metastatic tumors form primaries of the skin, bone, liver, breast, or heart. Primary pulmonary angiosarcomas are exceedingly rare, with just about 20 cases being reported in the literature. We report an additional case with a brief review of the literature of a primary pulmonary angiosarcoma in a 26-year-old lady who presented with intractable hemoptysis. In addition, we highlight the potential of fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography as an important diagnostic tool in the evaluation of this tumor and thus contribute to the existing sparse literature on this fascinating yet devastating disease.

No MeSH data available.


Related in: MedlinePlus