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Saraca indica bark extract shows in vitro antioxidant, antibreast cancer activity and does not exhibit toxicological effects.

Yadav NK, Saini KS, Hossain Z, Omer A, Sharma C, Gayen JR, Singh P, Arya KR, Singh RK - Oxid Med Cell Longev (2015)

Bottom Line: Multicomposed mixture of compounds present in a plant extract has synergistic activity, increases the therapeutic potential many folds, compensates toxicity, and increases bioavailability.Saraca indica (family Caesalpiniaceae) is one of the most ancient sacred plants with medicinal properties, exhibiting a number of pharmacological effects.The results of the study indicated that this herbal preparation has antioxidant and antibreast cancer activity.

View Article: PubMed Central - PubMed

Affiliation: Division of Toxicology, CSIR-Central Drug Research Institute, BS-10/1, Sector 10, Jankipuram Extension, Sitapur Road, P.O. Box 173, Lucknow 226031, India.

ABSTRACT
Medicinal plants are used as a complementary and alternative medicine in treatment of various diseases including cancer worldwide, because of their ease of accessibility and cost effectiveness. Multicomposed mixture of compounds present in a plant extract has synergistic activity, increases the therapeutic potential many folds, compensates toxicity, and increases bioavailability. Saraca indica (family Caesalpiniaceae) is one of the most ancient sacred plants with medicinal properties, exhibiting a number of pharmacological effects. Antioxidant, antibreast cancer activity and toxicological evaluation of Saraca indica bark extract (SIE) were carried out in the present study. The results of the study indicated that this herbal preparation has antioxidant and antibreast cancer activity. Toxicological studies suggest that SIE is safer to use and may have a potential to be used as complementary and alternative medicine for breast cancer therapy.

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Mass fingerprinting chromatogram of SIE in positive ion (M + 1) mode.
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Related In: Results  -  Collection


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fig7: Mass fingerprinting chromatogram of SIE in positive ion (M + 1) mode.

Mentions: Various components of different extracts of Saraca indica have been extensively reported as by Gahlaut et al. (2013), Kashima and Miyazawa (2012), Shirolkar et al. (2013), and Mittal et al. (2013) [26, 29, 75, 76]. The combined result of detected compounds from the mass spectrometric analysis and literature is shown in Table 9 (Figure 7).


Saraca indica bark extract shows in vitro antioxidant, antibreast cancer activity and does not exhibit toxicological effects.

Yadav NK, Saini KS, Hossain Z, Omer A, Sharma C, Gayen JR, Singh P, Arya KR, Singh RK - Oxid Med Cell Longev (2015)

Mass fingerprinting chromatogram of SIE in positive ion (M + 1) mode.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4378602&req=5

fig7: Mass fingerprinting chromatogram of SIE in positive ion (M + 1) mode.
Mentions: Various components of different extracts of Saraca indica have been extensively reported as by Gahlaut et al. (2013), Kashima and Miyazawa (2012), Shirolkar et al. (2013), and Mittal et al. (2013) [26, 29, 75, 76]. The combined result of detected compounds from the mass spectrometric analysis and literature is shown in Table 9 (Figure 7).

Bottom Line: Multicomposed mixture of compounds present in a plant extract has synergistic activity, increases the therapeutic potential many folds, compensates toxicity, and increases bioavailability.Saraca indica (family Caesalpiniaceae) is one of the most ancient sacred plants with medicinal properties, exhibiting a number of pharmacological effects.The results of the study indicated that this herbal preparation has antioxidant and antibreast cancer activity.

View Article: PubMed Central - PubMed

Affiliation: Division of Toxicology, CSIR-Central Drug Research Institute, BS-10/1, Sector 10, Jankipuram Extension, Sitapur Road, P.O. Box 173, Lucknow 226031, India.

ABSTRACT
Medicinal plants are used as a complementary and alternative medicine in treatment of various diseases including cancer worldwide, because of their ease of accessibility and cost effectiveness. Multicomposed mixture of compounds present in a plant extract has synergistic activity, increases the therapeutic potential many folds, compensates toxicity, and increases bioavailability. Saraca indica (family Caesalpiniaceae) is one of the most ancient sacred plants with medicinal properties, exhibiting a number of pharmacological effects. Antioxidant, antibreast cancer activity and toxicological evaluation of Saraca indica bark extract (SIE) were carried out in the present study. The results of the study indicated that this herbal preparation has antioxidant and antibreast cancer activity. Toxicological studies suggest that SIE is safer to use and may have a potential to be used as complementary and alternative medicine for breast cancer therapy.

Show MeSH
Related in: MedlinePlus