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Helicobacter pylori Infection Is Associated with an Increased Risk of Hyperemesis Gravidarum: A Meta-Analysis.

Li L, Li L, Zhou X, Xiao S, Gu H, Zhang G - Gastroenterol Res Pract (2015)

Bottom Line: Results.H. pylori should be considered one of the risk factors of HG, especially in the developing countries.H. pylori eradication could be considered to relieve the symptoms of HG in some intractable cases.

View Article: PubMed Central - PubMed

Affiliation: Department of Gastroenterology, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China ; First Clinical Medical College, Nanjing Medical University, Nanjing 210029, China.

ABSTRACT
Background. Several studies have shown a possible involvement of Helicobacter pylori (H. pylori) infection in individuals with hyperemesis gravidarum (HG), but the relationship remains controversial. This meta-analysis was performed to validate and strengthen the association between HG and H. pylori infection. Methods. PubMed, Embase, and Web of Science databases up to March 20, 2014, were searched to select studies on the prevalence of H. pylori infection between pregnant women with HG and the normal pregnant control subjects. Results. Of the HG cases, 1289 (69.6%) were H. pylori-positive; however, 1045 (46.2%) were H. pylori-positive in control group. Compared to the non-HG normal pregnant controls, infection rate of H. pylori was significantly higher in pregnant women with HG (OR = 3.34, 95% CI: 2.32-4.81, P < 0.001). Subgroup analysis indicated that H. pylori infection was a risk factor of HG in Asia, Africa, and Oceania, especially in Africa (OR = 12.38, 95% CI: 7.12-21.54, P < 0.001). Conclusions. H. pylori should be considered one of the risk factors of HG, especially in the developing countries. H. pylori eradication could be considered to relieve the symptoms of HG in some intractable cases.

No MeSH data available.


Related in: MedlinePlus

Flow chart of the literature searches for evaluating Helicobacter pylori infection and hyperemesis gravidarum.
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fig1: Flow chart of the literature searches for evaluating Helicobacter pylori infection and hyperemesis gravidarum.

Mentions: As shown in Figure 1, after rigorous searching, we identified 104 citations. Of these, fifty-six irrelevant papers were excluded after screening the titles. In the remaining 48 articles, 16 studies included five studies without control group, two did not provide sufficient data, and 9 reviews or meta-analyses were discarded. Thus, a total of thirty-two studies included twenty-nine case-control studies and three cross-sectional studies published between 1998 and 2014 fulfilled our inclusion criteria and were included in the meta-analysis [3–6, 16–43].


Helicobacter pylori Infection Is Associated with an Increased Risk of Hyperemesis Gravidarum: A Meta-Analysis.

Li L, Li L, Zhou X, Xiao S, Gu H, Zhang G - Gastroenterol Res Pract (2015)

Flow chart of the literature searches for evaluating Helicobacter pylori infection and hyperemesis gravidarum.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4378596&req=5

fig1: Flow chart of the literature searches for evaluating Helicobacter pylori infection and hyperemesis gravidarum.
Mentions: As shown in Figure 1, after rigorous searching, we identified 104 citations. Of these, fifty-six irrelevant papers were excluded after screening the titles. In the remaining 48 articles, 16 studies included five studies without control group, two did not provide sufficient data, and 9 reviews or meta-analyses were discarded. Thus, a total of thirty-two studies included twenty-nine case-control studies and three cross-sectional studies published between 1998 and 2014 fulfilled our inclusion criteria and were included in the meta-analysis [3–6, 16–43].

Bottom Line: Results.H. pylori should be considered one of the risk factors of HG, especially in the developing countries.H. pylori eradication could be considered to relieve the symptoms of HG in some intractable cases.

View Article: PubMed Central - PubMed

Affiliation: Department of Gastroenterology, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China ; First Clinical Medical College, Nanjing Medical University, Nanjing 210029, China.

ABSTRACT
Background. Several studies have shown a possible involvement of Helicobacter pylori (H. pylori) infection in individuals with hyperemesis gravidarum (HG), but the relationship remains controversial. This meta-analysis was performed to validate and strengthen the association between HG and H. pylori infection. Methods. PubMed, Embase, and Web of Science databases up to March 20, 2014, were searched to select studies on the prevalence of H. pylori infection between pregnant women with HG and the normal pregnant control subjects. Results. Of the HG cases, 1289 (69.6%) were H. pylori-positive; however, 1045 (46.2%) were H. pylori-positive in control group. Compared to the non-HG normal pregnant controls, infection rate of H. pylori was significantly higher in pregnant women with HG (OR = 3.34, 95% CI: 2.32-4.81, P < 0.001). Subgroup analysis indicated that H. pylori infection was a risk factor of HG in Asia, Africa, and Oceania, especially in Africa (OR = 12.38, 95% CI: 7.12-21.54, P < 0.001). Conclusions. H. pylori should be considered one of the risk factors of HG, especially in the developing countries. H. pylori eradication could be considered to relieve the symptoms of HG in some intractable cases.

No MeSH data available.


Related in: MedlinePlus