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Alternative antimicrobial approach: nano-antimicrobial materials.

Beyth N, Houri-Haddad Y, Domb A, Khan W, Hazan R - Evid Based Complement Alternat Med (2015)

Bottom Line: Consequently, attention has been especially devoted to new and emerging nanoparticle-based materials in the field of antimicrobial chemotherapy.The present review discusses the activities of nanoparticles as an antimicrobial means, their mode of action, nanoparticle effect on drug-resistant bacteria, and the risks attendant on their use as antibacterial agents.Factors contributing to nanoparticle performance in the clinical setting, their unique properties, and mechanism of action as antibacterial agents are discussed in detail.

View Article: PubMed Central - PubMed

Affiliation: Department of Prosthodontics, The Hebrew University-Hadassah School of Dental Medicine, P.O. Box 12272, 91120 Jerusalem, Israel.

ABSTRACT
Despite numerous existing potent antibiotics and other antimicrobial means, bacterial infections are still a major cause of morbidity and mortality. Moreover, the need to develop additional bactericidal means has significantly increased due to the growing concern regarding multidrug-resistant bacterial strains and biofilm associated infections. Consequently, attention has been especially devoted to new and emerging nanoparticle-based materials in the field of antimicrobial chemotherapy. The present review discusses the activities of nanoparticles as an antimicrobial means, their mode of action, nanoparticle effect on drug-resistant bacteria, and the risks attendant on their use as antibacterial agents. Factors contributing to nanoparticle performance in the clinical setting, their unique properties, and mechanism of action as antibacterial agents are discussed in detail.

No MeSH data available.


Related in: MedlinePlus

Toxicological mechanisms of NM to eukaryotic cells. Nanoparticles induce ROS generation in eukaryotic cells; these radicals cause severe oxidation stress in the cells, affecting membrane lipids and altering the structure of DNA and proteins. This excess radical production induces an inflammatory process that could lead to cell death.
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sch3: Toxicological mechanisms of NM to eukaryotic cells. Nanoparticles induce ROS generation in eukaryotic cells; these radicals cause severe oxidation stress in the cells, affecting membrane lipids and altering the structure of DNA and proteins. This excess radical production induces an inflammatory process that could lead to cell death.

Mentions: Despite the numerous advantages that antibacterial NM offer, they also have some imperative shortcomings. Nanomaterials may be toxic to human cells and tissue, causing oxidative stress, disturbing enzymes activity, and causing membrane and DNA damage, all of which lead to cell death (Scheme 3). Nonetheless, recent studies show that NM have the potential to be efficient antibacterial agents, provided their main disadvantage, toxicity, will be addressed.


Alternative antimicrobial approach: nano-antimicrobial materials.

Beyth N, Houri-Haddad Y, Domb A, Khan W, Hazan R - Evid Based Complement Alternat Med (2015)

Toxicological mechanisms of NM to eukaryotic cells. Nanoparticles induce ROS generation in eukaryotic cells; these radicals cause severe oxidation stress in the cells, affecting membrane lipids and altering the structure of DNA and proteins. This excess radical production induces an inflammatory process that could lead to cell death.
© Copyright Policy - open-access
Related In: Results  -  Collection

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getmorefigures.php?uid=PMC4378595&req=5

sch3: Toxicological mechanisms of NM to eukaryotic cells. Nanoparticles induce ROS generation in eukaryotic cells; these radicals cause severe oxidation stress in the cells, affecting membrane lipids and altering the structure of DNA and proteins. This excess radical production induces an inflammatory process that could lead to cell death.
Mentions: Despite the numerous advantages that antibacterial NM offer, they also have some imperative shortcomings. Nanomaterials may be toxic to human cells and tissue, causing oxidative stress, disturbing enzymes activity, and causing membrane and DNA damage, all of which lead to cell death (Scheme 3). Nonetheless, recent studies show that NM have the potential to be efficient antibacterial agents, provided their main disadvantage, toxicity, will be addressed.

Bottom Line: Consequently, attention has been especially devoted to new and emerging nanoparticle-based materials in the field of antimicrobial chemotherapy.The present review discusses the activities of nanoparticles as an antimicrobial means, their mode of action, nanoparticle effect on drug-resistant bacteria, and the risks attendant on their use as antibacterial agents.Factors contributing to nanoparticle performance in the clinical setting, their unique properties, and mechanism of action as antibacterial agents are discussed in detail.

View Article: PubMed Central - PubMed

Affiliation: Department of Prosthodontics, The Hebrew University-Hadassah School of Dental Medicine, P.O. Box 12272, 91120 Jerusalem, Israel.

ABSTRACT
Despite numerous existing potent antibiotics and other antimicrobial means, bacterial infections are still a major cause of morbidity and mortality. Moreover, the need to develop additional bactericidal means has significantly increased due to the growing concern regarding multidrug-resistant bacterial strains and biofilm associated infections. Consequently, attention has been especially devoted to new and emerging nanoparticle-based materials in the field of antimicrobial chemotherapy. The present review discusses the activities of nanoparticles as an antimicrobial means, their mode of action, nanoparticle effect on drug-resistant bacteria, and the risks attendant on their use as antibacterial agents. Factors contributing to nanoparticle performance in the clinical setting, their unique properties, and mechanism of action as antibacterial agents are discussed in detail.

No MeSH data available.


Related in: MedlinePlus