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The temporal unfolding of face processing in social anxiety disorder--a MEG study.

Riwkes S, Goldstein A, Gilboa-Schechtman E - Neuroimage Clin (2014)

Bottom Line: We expected that, compared to healthy controls (HCs), participants with SAD will show an early (<200 ms post-stimulus) over-activation in the insula and the fusiform gyrus (FG, associated with the N170/M170 component), and later (>200 ms post-stimulus) over-activation in the dorsolateral prefrontal cortex (DLPFC).As compared to the HC group, the SAD group showed a reduced M170 (right FG under-activation around 130-200 ms); early reduced activation in the right insula, and lower insular sensitivity to the type of EFE displayed.This unique EFE processing pattern in SAD suggests an early under-activation of cortical areas, possibly related to reduced emphasis on high spatial frequency information and greater early emphasis on low spatial frequency information.

View Article: PubMed Central - PubMed

Affiliation: Department of Psychology, Bar Ilan University, Ramat Gan 52900, Israel.

ABSTRACT
The current study is the first to use magnetoencephalography (MEG) to examine how individuals with social anxiety disorder (SAD) process emotional facial expressions (EFEs). We expected that, compared to healthy controls (HCs), participants with SAD will show an early (<200 ms post-stimulus) over-activation in the insula and the fusiform gyrus (FG, associated with the N170/M170 component), and later (>200 ms post-stimulus) over-activation in the dorsolateral prefrontal cortex (DLPFC). Individuals with SAD (n = 12) and healthy controls (HCs, n = 12) were presented with photographs of facial displays during MEG recording. As compared to the HC group, the SAD group showed a reduced M170 (right FG under-activation around 130-200 ms); early reduced activation in the right insula, and lower insular sensitivity to the type of EFE displayed. In addition, the SAD group showed a late over-activation in the right DLPFC. This unique EFE processing pattern in SAD suggests an early under-activation of cortical areas, possibly related to reduced emphasis on high spatial frequency information and greater early emphasis on low spatial frequency information. The late DLPFC over-activation in the SAD group may correlate to failures of cognitive control in this disorder. The importance of a temporal perspective for the understanding of facial processing in psychopathology is underlined.

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Related in: MedlinePlus

Grand-averaged MEG data for (a) HC group and (b) SAD group, with all sensors overlaid, showing the four times-of-interest in our study: (1) 70–130 ms, (2) 130–200 ms, (3) 200–300 ms, and (4) 300–500 ms.
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f0005: Grand-averaged MEG data for (a) HC group and (b) SAD group, with all sensors overlaid, showing the four times-of-interest in our study: (1) 70–130 ms, (2) 130–200 ms, (3) 200–300 ms, and (4) 300–500 ms.

Mentions: As shown in Fig. 1, sensor-level analyses revealed four main time-windows of activity (times-of-interest): (1) 70–130 ms, (2) 130–200 ms, which encompassed the M170 component, (3) 200–300 ms, and (4) 300–500 ms. These time-windows corresponded with previous research, which identified the early visual components at around 100 ms, the M170 component at around 150 ms, and late components from 200 onwards. Fig. 1a and b presents the grand-averaged MEG data, with all sensors overlaid, for the SAD and HC groups separately.


The temporal unfolding of face processing in social anxiety disorder--a MEG study.

Riwkes S, Goldstein A, Gilboa-Schechtman E - Neuroimage Clin (2014)

Grand-averaged MEG data for (a) HC group and (b) SAD group, with all sensors overlaid, showing the four times-of-interest in our study: (1) 70–130 ms, (2) 130–200 ms, (3) 200–300 ms, and (4) 300–500 ms.
© Copyright Policy - CC BY-NC-ND
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4377840&req=5

f0005: Grand-averaged MEG data for (a) HC group and (b) SAD group, with all sensors overlaid, showing the four times-of-interest in our study: (1) 70–130 ms, (2) 130–200 ms, (3) 200–300 ms, and (4) 300–500 ms.
Mentions: As shown in Fig. 1, sensor-level analyses revealed four main time-windows of activity (times-of-interest): (1) 70–130 ms, (2) 130–200 ms, which encompassed the M170 component, (3) 200–300 ms, and (4) 300–500 ms. These time-windows corresponded with previous research, which identified the early visual components at around 100 ms, the M170 component at around 150 ms, and late components from 200 onwards. Fig. 1a and b presents the grand-averaged MEG data, with all sensors overlaid, for the SAD and HC groups separately.

Bottom Line: We expected that, compared to healthy controls (HCs), participants with SAD will show an early (<200 ms post-stimulus) over-activation in the insula and the fusiform gyrus (FG, associated with the N170/M170 component), and later (>200 ms post-stimulus) over-activation in the dorsolateral prefrontal cortex (DLPFC).As compared to the HC group, the SAD group showed a reduced M170 (right FG under-activation around 130-200 ms); early reduced activation in the right insula, and lower insular sensitivity to the type of EFE displayed.This unique EFE processing pattern in SAD suggests an early under-activation of cortical areas, possibly related to reduced emphasis on high spatial frequency information and greater early emphasis on low spatial frequency information.

View Article: PubMed Central - PubMed

Affiliation: Department of Psychology, Bar Ilan University, Ramat Gan 52900, Israel.

ABSTRACT
The current study is the first to use magnetoencephalography (MEG) to examine how individuals with social anxiety disorder (SAD) process emotional facial expressions (EFEs). We expected that, compared to healthy controls (HCs), participants with SAD will show an early (<200 ms post-stimulus) over-activation in the insula and the fusiform gyrus (FG, associated with the N170/M170 component), and later (>200 ms post-stimulus) over-activation in the dorsolateral prefrontal cortex (DLPFC). Individuals with SAD (n = 12) and healthy controls (HCs, n = 12) were presented with photographs of facial displays during MEG recording. As compared to the HC group, the SAD group showed a reduced M170 (right FG under-activation around 130-200 ms); early reduced activation in the right insula, and lower insular sensitivity to the type of EFE displayed. In addition, the SAD group showed a late over-activation in the right DLPFC. This unique EFE processing pattern in SAD suggests an early under-activation of cortical areas, possibly related to reduced emphasis on high spatial frequency information and greater early emphasis on low spatial frequency information. The late DLPFC over-activation in the SAD group may correlate to failures of cognitive control in this disorder. The importance of a temporal perspective for the understanding of facial processing in psychopathology is underlined.

Show MeSH
Related in: MedlinePlus