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A large temperature fluctuation may trigger an epidemic erythromelalgia outbreak in China.

Liu T, Zhang Y, Lin H, Lv X, Xiao J, Zeng W, Gu Y, Rutherford S, Tong S, Ma W - Sci Rep (2015)

Bottom Line: We observed that epidemic EM outbreaks were reported from 13 provinces during 1960-2014 and they mainly occurred between February and March in southern China.The majority of EM cases were middle school students, with a higher incidence rate in female and resident students.The major clinical characteristics of EM cases included burning, sharp, tingling and/or stinging pain in toes, soles and/or dorsum of feet, fever, erythema and swelling.

View Article: PubMed Central - PubMed

Affiliation: 1] Guangdong Provincial Institute of Public Health, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, 511430, China [2] Environment and Health, Guangdong Provincial Key Medical Discipline of Twelfth Five-Year Plan, Guangzhou, 511430, China.

ABSTRACT
Although erythromelalgia (EM) has been documented in the literature for almost 150 years, it is still poorly understood. To overcome this limitation, we examined the spatial distribution of epidemic EM, and explored the association between temperature fluctuation and epidemic EM outbreaks in China. We searched all peer-reviewed literature on primary epidemic EM outbreaks in China. A two-stage model was used to characterize the relationship between temperature fluctuation and epidemic EM outbreaks. We observed that epidemic EM outbreaks were reported from 13 provinces during 1960-2014 and they mainly occurred between February and March in southern China. The majority of EM cases were middle school students, with a higher incidence rate in female and resident students. The major clinical characteristics of EM cases included burning, sharp, tingling and/or stinging pain in toes, soles and/or dorsum of feet, fever, erythema and swelling. A large "V"-shaped fluctuation of daily average temperature (TM) observed during the epidemic EM outbreaks was significantly associated with the number of daily EM cases (β = 1.22, 95%CI: 0.66 ~ 1.79), which indicated that this "V"-shaped fluctuation of TM probably triggered the epidemic EM outbreaks.

No MeSH data available.


Related in: MedlinePlus

The distribution of epidemic EM events in China.Note: These maps were generated by ArcMap 9.3 software (Environmental Systems Research Institute, Redlands, USA).
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f2: The distribution of epidemic EM events in China.Note: These maps were generated by ArcMap 9.3 software (Environmental Systems Research Institute, Redlands, USA).

Mentions: A total of 54 regions located in 13 provinces experienced epidemic EM outbreaks from 1960 to 2014. Most regions were located in the southern part of China (south of the Yellow River). Two large outbreaks occurred in 1987 and 1990. The 1987 outbreak happened in central provinces in China including Hubei, Hunan and Jiangxi provinces (near the middle part of the Yangtze River), while the 1990 outbreak was mainly in south China including Fujian, Guangdong and Hainan provinces (Figure 2).


A large temperature fluctuation may trigger an epidemic erythromelalgia outbreak in China.

Liu T, Zhang Y, Lin H, Lv X, Xiao J, Zeng W, Gu Y, Rutherford S, Tong S, Ma W - Sci Rep (2015)

The distribution of epidemic EM events in China.Note: These maps were generated by ArcMap 9.3 software (Environmental Systems Research Institute, Redlands, USA).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4377627&req=5

f2: The distribution of epidemic EM events in China.Note: These maps were generated by ArcMap 9.3 software (Environmental Systems Research Institute, Redlands, USA).
Mentions: A total of 54 regions located in 13 provinces experienced epidemic EM outbreaks from 1960 to 2014. Most regions were located in the southern part of China (south of the Yellow River). Two large outbreaks occurred in 1987 and 1990. The 1987 outbreak happened in central provinces in China including Hubei, Hunan and Jiangxi provinces (near the middle part of the Yangtze River), while the 1990 outbreak was mainly in south China including Fujian, Guangdong and Hainan provinces (Figure 2).

Bottom Line: We observed that epidemic EM outbreaks were reported from 13 provinces during 1960-2014 and they mainly occurred between February and March in southern China.The majority of EM cases were middle school students, with a higher incidence rate in female and resident students.The major clinical characteristics of EM cases included burning, sharp, tingling and/or stinging pain in toes, soles and/or dorsum of feet, fever, erythema and swelling.

View Article: PubMed Central - PubMed

Affiliation: 1] Guangdong Provincial Institute of Public Health, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, 511430, China [2] Environment and Health, Guangdong Provincial Key Medical Discipline of Twelfth Five-Year Plan, Guangzhou, 511430, China.

ABSTRACT
Although erythromelalgia (EM) has been documented in the literature for almost 150 years, it is still poorly understood. To overcome this limitation, we examined the spatial distribution of epidemic EM, and explored the association between temperature fluctuation and epidemic EM outbreaks in China. We searched all peer-reviewed literature on primary epidemic EM outbreaks in China. A two-stage model was used to characterize the relationship between temperature fluctuation and epidemic EM outbreaks. We observed that epidemic EM outbreaks were reported from 13 provinces during 1960-2014 and they mainly occurred between February and March in southern China. The majority of EM cases were middle school students, with a higher incidence rate in female and resident students. The major clinical characteristics of EM cases included burning, sharp, tingling and/or stinging pain in toes, soles and/or dorsum of feet, fever, erythema and swelling. A large "V"-shaped fluctuation of daily average temperature (TM) observed during the epidemic EM outbreaks was significantly associated with the number of daily EM cases (β = 1.22, 95%CI: 0.66 ~ 1.79), which indicated that this "V"-shaped fluctuation of TM probably triggered the epidemic EM outbreaks.

No MeSH data available.


Related in: MedlinePlus