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Decreased Perifoveal Sensitivity Detected by Microperimetry in Patients Using Hydroxychloroquine and without Visual Field and Fundoscopic Anomalies.

Molina-Martín A, Piñero DP, Pérez-Cambrodí RJ - J Ophthalmol (2015)

Bottom Line: No significant differences were found in mean MP foveal sensitivity between groups (P = 0.18).However, mean MP overall sensitivity was significantly higher in group A (29.05 ± 0.57 dB versus group B, 26.05 ± 2.75 dB; P < 0.001).Conclusion.

View Article: PubMed Central - PubMed

Affiliation: Clínica Optométrica, Fundació Lluis Alcanyis, Universitat de Valencia, Calle de la Guardia Civil 22, 46020 Valencia, Spain.

ABSTRACT
Purpose. To evaluate the usefulness of microperimetry in the early detection of the ocular anomalies associated with the use of hydroxychloroquine. Methods. Prospective comparative case series study comprising 14 healthy eyes of 7 patients (group A) and 14 eyes of 7 patients under treatment with hydroxychloroquine for the treatment of rheumatologic diseases and without fundoscopic or perimetric anomalies (group B). A comprehensive ophthalmological examination including microperimetry (MP) and spectral-domain optical coherence tomography was performed in both groups. Results. No significant differences were found in mean MP foveal sensitivity between groups (P = 0.18). However, mean MP overall sensitivity was significantly higher in group A (29.05 ± 0.57 dB versus group B, 26.05 ± 2.75 dB; P < 0.001). Significantly higher sensitivity values were obtained in group A in comparison to group B for the three eccentric loci evaluated (P < 0.001). Conclusion. Microperimetry seems to be a useful tool for the early detection of retinal damage in patients treated with hydroxychloroquine.

No MeSH data available.


Related in: MedlinePlus

Examples of sensitivity maps obtained with the MAIA MP system: (a) sensitivity map of a patient under treatment with HCQ (group B); (b) sensitivity map of a healthy patient (group A).
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fig1: Examples of sensitivity maps obtained with the MAIA MP system: (a) sensitivity map of a patient under treatment with HCQ (group B); (b) sensitivity map of a healthy patient (group A).

Mentions: The measures of sensitivity with the microperimeter were obtained using the option “Expert Exam,” consisting of the application of a 4-2 staircase strategy of threshold in a static exam. This examination allowed us to obtain the value of the threshold in each point in 1 dB steps. The type of predefined grid used for the perimetry consisted of 37 projection positions distributed in three concentric circles around the center placed at 1°, 2°, and 5° positions, containing 12 points each. After the examination, the results of sensitivity in the different positions evaluated and the average threshold (AT) were plotted and compared with a normative database provided by the instrument in order to classify the case as normal or not (Figures 1(a) and 1(b)). MAIA microperimeter also provides more specific information about the patient's fixation pattern obtained from the raw data, such as the bivariate contour ellipse area (BCEA) that represents the area of the ellipse that better fits the fixation points recorded during the measurement and that is obtained after estimating the major and minor axes of such ellipse. The area was estimated in square degrees considering 63% and 95% of points.


Decreased Perifoveal Sensitivity Detected by Microperimetry in Patients Using Hydroxychloroquine and without Visual Field and Fundoscopic Anomalies.

Molina-Martín A, Piñero DP, Pérez-Cambrodí RJ - J Ophthalmol (2015)

Examples of sensitivity maps obtained with the MAIA MP system: (a) sensitivity map of a patient under treatment with HCQ (group B); (b) sensitivity map of a healthy patient (group A).
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4377466&req=5

fig1: Examples of sensitivity maps obtained with the MAIA MP system: (a) sensitivity map of a patient under treatment with HCQ (group B); (b) sensitivity map of a healthy patient (group A).
Mentions: The measures of sensitivity with the microperimeter were obtained using the option “Expert Exam,” consisting of the application of a 4-2 staircase strategy of threshold in a static exam. This examination allowed us to obtain the value of the threshold in each point in 1 dB steps. The type of predefined grid used for the perimetry consisted of 37 projection positions distributed in three concentric circles around the center placed at 1°, 2°, and 5° positions, containing 12 points each. After the examination, the results of sensitivity in the different positions evaluated and the average threshold (AT) were plotted and compared with a normative database provided by the instrument in order to classify the case as normal or not (Figures 1(a) and 1(b)). MAIA microperimeter also provides more specific information about the patient's fixation pattern obtained from the raw data, such as the bivariate contour ellipse area (BCEA) that represents the area of the ellipse that better fits the fixation points recorded during the measurement and that is obtained after estimating the major and minor axes of such ellipse. The area was estimated in square degrees considering 63% and 95% of points.

Bottom Line: No significant differences were found in mean MP foveal sensitivity between groups (P = 0.18).However, mean MP overall sensitivity was significantly higher in group A (29.05 ± 0.57 dB versus group B, 26.05 ± 2.75 dB; P < 0.001).Conclusion.

View Article: PubMed Central - PubMed

Affiliation: Clínica Optométrica, Fundació Lluis Alcanyis, Universitat de Valencia, Calle de la Guardia Civil 22, 46020 Valencia, Spain.

ABSTRACT
Purpose. To evaluate the usefulness of microperimetry in the early detection of the ocular anomalies associated with the use of hydroxychloroquine. Methods. Prospective comparative case series study comprising 14 healthy eyes of 7 patients (group A) and 14 eyes of 7 patients under treatment with hydroxychloroquine for the treatment of rheumatologic diseases and without fundoscopic or perimetric anomalies (group B). A comprehensive ophthalmological examination including microperimetry (MP) and spectral-domain optical coherence tomography was performed in both groups. Results. No significant differences were found in mean MP foveal sensitivity between groups (P = 0.18). However, mean MP overall sensitivity was significantly higher in group A (29.05 ± 0.57 dB versus group B, 26.05 ± 2.75 dB; P < 0.001). Significantly higher sensitivity values were obtained in group A in comparison to group B for the three eccentric loci evaluated (P < 0.001). Conclusion. Microperimetry seems to be a useful tool for the early detection of retinal damage in patients treated with hydroxychloroquine.

No MeSH data available.


Related in: MedlinePlus