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Analysis of the Results from the Patch Test to Para-Phenylenediamine in the TRUE Test in Patients with a Hair Dye Contact Allergy.

Lee JY, Kim CW, Kim SS - Ann Dermatol (2015)

Bottom Line: Although there was a significant correlation between HDCA and PPD sensitization (p=0.001), only 40% of the patients with HDCA showed positive reactions to PPD.This study's findings show that PPD is an effective HDCA marker.However, we propose that investigations on hair dye components other than PPD should be conducted to develop and validate additional predictive HDCA markers.

View Article: PubMed Central - PubMed

Affiliation: Department of Dermatology, Kangdong Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea.

ABSTRACT

Background: Para-phenylenediamine (PPD) is the primary patch test screening agent for hair dye contact allergy (HDCA). However, no recent studies have been published that describe the results of reactions to patch tests using PPD and hair dyes in Korea.

Objective: To analyze the results of the patch tests to PPD using the thin-layer rapid use epicutaneous (TRUE) Test system in patients with HDCA and to investigate patients' awareness that hair dyes contains allergens, which cause the development of HDCA.

Methods: Eighty-four patients with suspected HDCA (32 men and 52 women) underwent patch testing using the TRUE Test system and their own hair dyes. The patients' demographic data, behavior associated with hair dyeing, and clinical manifestations of HDCA were examined retrospectively.

Results: Positive patch-test reactions to hair dyes occurred in 53.6% of patients who used hair dyes, and they were diagnosed with HDCA. Although there was a significant correlation between HDCA and PPD sensitization (p=0.001), only 40% of the patients with HDCA showed positive reactions to PPD. Of the 45 patients diagnosed with HDCA, only 7 (15.6%) were aware that their hair dyes contained allergens that caused HDCA.

Conclusion: This study's findings show that PPD is an effective HDCA marker. However, we propose that investigations on hair dye components other than PPD should be conducted to develop and validate additional predictive HDCA markers.

No MeSH data available.


Patch-test readings after 96 hours. (A) Positive reactions to two different types of hair dye components (para-phenylenediamine [PPD] and urushiol) are shown in patient 1. (B) Positive reactions to three different types of hair dye components and PPD are shown in patient 2. Doubtful reactions to nickel and chrome are also shown.
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Figure 1: Patch-test readings after 96 hours. (A) Positive reactions to two different types of hair dye components (para-phenylenediamine [PPD] and urushiol) are shown in patient 1. (B) Positive reactions to three different types of hair dye components and PPD are shown in patient 2. Doubtful reactions to nickel and chrome are also shown.

Mentions: The patch-test results were read twice. An antigen was attached to the subject's skin, which was sealed and then removed after 48 h. The primary reading was performed 30 min after the removal of the antigen, and the secondary reading was performed 48 h after the first reading. Irritant reactions due to hyperirritable skin were excluded by a trained dermatologist, and the test was repeated in 1 month when the patient's skin became less irritable. Based on the International Contact Dermatitis Research Group's criteria, the patch-test results were categorized as negative (-), doubtful (?), weakly positive (+), strongly positive (+ +), or extremely positive (+++). A positive reaction was defined as at least one reading (either the primary or secondary) that was weakly positive (+) or higher. When a positive reaction to the hair dye was observed in a patch test, HDCA was definitively diagnosed (Fig. 1).


Analysis of the Results from the Patch Test to Para-Phenylenediamine in the TRUE Test in Patients with a Hair Dye Contact Allergy.

Lee JY, Kim CW, Kim SS - Ann Dermatol (2015)

Patch-test readings after 96 hours. (A) Positive reactions to two different types of hair dye components (para-phenylenediamine [PPD] and urushiol) are shown in patient 1. (B) Positive reactions to three different types of hair dye components and PPD are shown in patient 2. Doubtful reactions to nickel and chrome are also shown.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4377406&req=5

Figure 1: Patch-test readings after 96 hours. (A) Positive reactions to two different types of hair dye components (para-phenylenediamine [PPD] and urushiol) are shown in patient 1. (B) Positive reactions to three different types of hair dye components and PPD are shown in patient 2. Doubtful reactions to nickel and chrome are also shown.
Mentions: The patch-test results were read twice. An antigen was attached to the subject's skin, which was sealed and then removed after 48 h. The primary reading was performed 30 min after the removal of the antigen, and the secondary reading was performed 48 h after the first reading. Irritant reactions due to hyperirritable skin were excluded by a trained dermatologist, and the test was repeated in 1 month when the patient's skin became less irritable. Based on the International Contact Dermatitis Research Group's criteria, the patch-test results were categorized as negative (-), doubtful (?), weakly positive (+), strongly positive (+ +), or extremely positive (+++). A positive reaction was defined as at least one reading (either the primary or secondary) that was weakly positive (+) or higher. When a positive reaction to the hair dye was observed in a patch test, HDCA was definitively diagnosed (Fig. 1).

Bottom Line: Although there was a significant correlation between HDCA and PPD sensitization (p=0.001), only 40% of the patients with HDCA showed positive reactions to PPD.This study's findings show that PPD is an effective HDCA marker.However, we propose that investigations on hair dye components other than PPD should be conducted to develop and validate additional predictive HDCA markers.

View Article: PubMed Central - PubMed

Affiliation: Department of Dermatology, Kangdong Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea.

ABSTRACT

Background: Para-phenylenediamine (PPD) is the primary patch test screening agent for hair dye contact allergy (HDCA). However, no recent studies have been published that describe the results of reactions to patch tests using PPD and hair dyes in Korea.

Objective: To analyze the results of the patch tests to PPD using the thin-layer rapid use epicutaneous (TRUE) Test system in patients with HDCA and to investigate patients' awareness that hair dyes contains allergens, which cause the development of HDCA.

Methods: Eighty-four patients with suspected HDCA (32 men and 52 women) underwent patch testing using the TRUE Test system and their own hair dyes. The patients' demographic data, behavior associated with hair dyeing, and clinical manifestations of HDCA were examined retrospectively.

Results: Positive patch-test reactions to hair dyes occurred in 53.6% of patients who used hair dyes, and they were diagnosed with HDCA. Although there was a significant correlation between HDCA and PPD sensitization (p=0.001), only 40% of the patients with HDCA showed positive reactions to PPD. Of the 45 patients diagnosed with HDCA, only 7 (15.6%) were aware that their hair dyes contained allergens that caused HDCA.

Conclusion: This study's findings show that PPD is an effective HDCA marker. However, we propose that investigations on hair dye components other than PPD should be conducted to develop and validate additional predictive HDCA markers.

No MeSH data available.