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Temporal regulation of peripheral BDNF levels during cocaine and morphine withdrawal: comparison with a natural reward.

Geoffroy HA, Puig S, Benturquia N, Noble F - Int. J. Neuropsychopharmacol. (2014)

Bottom Line: Cocaine treatment led to a rapid (WD1) and persistent (WD14) decrease of basal BDNF levels compared with saline-treated animals, whereas morphine induced an increase on WD14 without any alteration on WD1.On the contrary, the natural reward induced a significant increase of basal brain-derived neurotrophic factor levels only on WD1.The analysis of BDNF levels at the usual time point at which animals had been exposed showed that both drugs, but not the natural reward, increased BDNF levels compared with basal levels.

View Article: PubMed Central - PubMed

Affiliation: Centre National de la Recherche Scientifique, France (Ms Geoffroy, Drs Puig and Noble); Institut National de la Santé et de la Recherche Médicale, France (Ms Geoffroy, Drs Puig, Benturquia, and Noble); Université Paris Descartes, Paris, France (Ms Geoffroy, Drs Puig, Benturquia, and Noble).

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Brain-derived neurotrophic factor (BDNF) levels in control rats at the usual hour of saline injection and on a basal level on withdrawal day 1 (WD1). Each rat received 14 days of saline injection and was sacrificed either at the usual hour of injection or at another time of saline injection on WD1 (basal level). Data (mean ± SEM) are expressed as percent of BDNF level normalized to basal levels (n=6–10) and were compared by a 2-tailed Student t-test.
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Figure 2: Brain-derived neurotrophic factor (BDNF) levels in control rats at the usual hour of saline injection and on a basal level on withdrawal day 1 (WD1). Each rat received 14 days of saline injection and was sacrificed either at the usual hour of injection or at another time of saline injection on WD1 (basal level). Data (mean ± SEM) are expressed as percent of BDNF level normalized to basal levels (n=6–10) and were compared by a 2-tailed Student t-test.

Mentions: We first analyzed the plasma BDNF level of saline-treated rats to ensure that 14 days of saline injections do not alter the BDNF level at the usual hour of injection compared with the basal level. We showed that there was no modification of the BDNF levels between the 2 time points (t(13)=0.38, P=.71) (Figure 2).


Temporal regulation of peripheral BDNF levels during cocaine and morphine withdrawal: comparison with a natural reward.

Geoffroy HA, Puig S, Benturquia N, Noble F - Int. J. Neuropsychopharmacol. (2014)

Brain-derived neurotrophic factor (BDNF) levels in control rats at the usual hour of saline injection and on a basal level on withdrawal day 1 (WD1). Each rat received 14 days of saline injection and was sacrificed either at the usual hour of injection or at another time of saline injection on WD1 (basal level). Data (mean ± SEM) are expressed as percent of BDNF level normalized to basal levels (n=6–10) and were compared by a 2-tailed Student t-test.
© Copyright Policy - creative-commons
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4376544&req=5

Figure 2: Brain-derived neurotrophic factor (BDNF) levels in control rats at the usual hour of saline injection and on a basal level on withdrawal day 1 (WD1). Each rat received 14 days of saline injection and was sacrificed either at the usual hour of injection or at another time of saline injection on WD1 (basal level). Data (mean ± SEM) are expressed as percent of BDNF level normalized to basal levels (n=6–10) and were compared by a 2-tailed Student t-test.
Mentions: We first analyzed the plasma BDNF level of saline-treated rats to ensure that 14 days of saline injections do not alter the BDNF level at the usual hour of injection compared with the basal level. We showed that there was no modification of the BDNF levels between the 2 time points (t(13)=0.38, P=.71) (Figure 2).

Bottom Line: Cocaine treatment led to a rapid (WD1) and persistent (WD14) decrease of basal BDNF levels compared with saline-treated animals, whereas morphine induced an increase on WD14 without any alteration on WD1.On the contrary, the natural reward induced a significant increase of basal brain-derived neurotrophic factor levels only on WD1.The analysis of BDNF levels at the usual time point at which animals had been exposed showed that both drugs, but not the natural reward, increased BDNF levels compared with basal levels.

View Article: PubMed Central - PubMed

Affiliation: Centre National de la Recherche Scientifique, France (Ms Geoffroy, Drs Puig and Noble); Institut National de la Santé et de la Recherche Médicale, France (Ms Geoffroy, Drs Puig, Benturquia, and Noble); Université Paris Descartes, Paris, France (Ms Geoffroy, Drs Puig, Benturquia, and Noble).

Show MeSH
Related in: MedlinePlus