Overlapping dose responses of spermatogenic and extragonadal testosterone actions jeopardize the principle of hormonal male contraception.
Bottom Line: Testosterone (T), alone or in combination with progestin, provides a promising approach to hormonal male contraception.A serious drawback of the treatment is that a significant proportion of men do not reach azoospermia or severe oligozoospermia, commensurate with contraceptive efficacy.Conspicuously, all dose responses to T were practically superimposable, and no dose of T could be defined that would maintain sexual function and suppress gonadotropins without simultaneously activating spermatogenesis.
Affiliation: Institute of Reproductive and Developmental Biology, Department of Surgery and Cancer, and.Show MeSH
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Mentions: The H&E staining of the LHR−/− mouse testes (Fig. 4B) and those of the mice treated with 0.5 mg T (data not shown) and 1.5 mg T (Fig. 4C) revealed similar cellular architecture. They were marked by narrow seminiferous tubules (Table 1), decreased number and size of Leydig cells, and arrested spermatogenesis at the round spermatid stage, as compared with WT testes (Fig. 4A), which showed normal spermatogenesis and formation of seminiferous tubular lumen surrounded by mature elongated spermatids. In mice treated with 2.5 mg T (Fig. 4D), progression of spermatogenesis to elongated spermatids was present in a few seminiferous tubules per section of testis (arrowed). In mice treated with 5.0 mg T (Fig. 4E) and the Silastic T implants (Fig. 4F), numerous elongated spermatids, indistinguishable from the WT testes, were observed in all seminiferous tubule sections.
Affiliation: Institute of Reproductive and Developmental Biology, Department of Surgery and Cancer, and.