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In this study, Nakaguro et al. examined PES1's role in NB cells and found that not only high PES1 levels corresponded to a clinically unfavorable prognosis, but also that knockdown of PES1 demonstrated suppression of tumor growth and inducement of apoptosis... This revolutionary study offers insight into a potentially devastating diagnosis and hope for a possible future target. doi: 10.1111/cas.12598 Page 237–43 Page 227–36 Acute myloid leukemia (AML) is a leukemia that sometimes confers a poor prognosis, often due to the inability of chemotherapy to destroy leukemic stem cells that continue to proliferate cancerous cells... Chromosome translocations that involve the mixed lineage leukemia gene (MLL) are frequently observed in acute myeloid leukemia (AML) and often predict a poor prognosis... Here, Aikawa et al. studied one such chromosomal translocation with PU.1 and found it to be integral in the upregulation and proliferation of leukemic stem cells and that the deletion of PU.1 results in the death of leukemic stem cells... This exciting breakthrough further differentiates what path resistant AML might take and provides a possible future target for therapy. doi: 10.1111/cas.12593 In this study, performed by Lin and coworkers, mice genetically engineered to express lower level of HO-1 and their wild type control mice were injected with lung carcinoma cells subcutaneously or melanoma cells intravenously and later evaluated for the development of metastatic lesions in the lungs... In doing so, the authors were able to demonstrate the potential involvement of HO-1 expression in hematopoietic cell compartment in promoting metastatic disease in the lungs through modulating the microenvironment... This finding strongly suggests that HO-1 also influences cancer metastasis to distant tissues and implicates it as a potential target in future drug discovery studies. doi: 10.1111/cas.12604 Page 299–306

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View Article: PubMed Central

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

In this study, Nakaguro et al. examined PES1's role in NB cells and found that not only high PES1 levels corresponded to a clinically unfavorable prognosis, but also that knockdown of PES1 demonstrated suppression of tumor growth and inducement of apoptosis... This revolutionary study offers insight into a potentially devastating diagnosis and hope for a possible future target. doi: 10.1111/cas.12598 Page 237–43 Page 227–36 Acute myloid leukemia (AML) is a leukemia that sometimes confers a poor prognosis, often due to the inability of chemotherapy to destroy leukemic stem cells that continue to proliferate cancerous cells... Chromosome translocations that involve the mixed lineage leukemia gene (MLL) are frequently observed in acute myeloid leukemia (AML) and often predict a poor prognosis... Here, Aikawa et al. studied one such chromosomal translocation with PU.1 and found it to be integral in the upregulation and proliferation of leukemic stem cells and that the deletion of PU.1 results in the death of leukemic stem cells... This exciting breakthrough further differentiates what path resistant AML might take and provides a possible future target for therapy. doi: 10.1111/cas.12593 In this study, performed by Lin and coworkers, mice genetically engineered to express lower level of HO-1 and their wild type control mice were injected with lung carcinoma cells subcutaneously or melanoma cells intravenously and later evaluated for the development of metastatic lesions in the lungs... In doing so, the authors were able to demonstrate the potential involvement of HO-1 expression in hematopoietic cell compartment in promoting metastatic disease in the lungs through modulating the microenvironment... This finding strongly suggests that HO-1 also influences cancer metastasis to distant tissues and implicates it as a potential target in future drug discovery studies. doi: 10.1111/cas.12604 Page 299–306

No MeSH data available.