Altered intracellular region of MUC1 and disrupted correlation of polarity-related molecules in breast cancer subtypes.
Bottom Line: Localization of MUC1 protein varied among breast cancer subtypes, that is, both the apical domain and cytoplasm in luminal A-like tumors (P < 0.01) and both the cytoplasm and cell membrane in luminal B-like (growth factor receptor 2 [HER2]+) tumors (P < 0.05), and no expression was found in triple negative tumors (P < 0.001).The incidence of mutual correlations of expression levels between two of the 10 molecules (55 combinations) was 54.5% in normal breast tissue and 38.2% in luminal A-like specimens, 16.4% in luminal B-like (HER2+), 3.6% in HER2 and 18.2% in triple negative specimens.In conclusion, each breast cancer subtype has characteristic cytoplasmic localization patterns of MUC1 and different degrees of disrupted correlation of the expression levels between the 10 examined molecules in comparison with normal breast tissue.
Affiliation: Department of Breast and Endocrine Surgery, Nihon University School of Medicine, Tokyo, Japan.Show MeSH
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Mentions: MUC1/CORE immunoreactivity was positive in 93.9% of samples (123/131) and localized at the apical domain, in the cytoplasm and/or at the cell membrane. The localization of MUC1 protein was classified into six patterns (Fig.1a–f): (1) apical domain only; (2) at both the apical domain and in the cytoplasm; (3) at the apical domain, in the cytoplasm and at the cell membrane; (4) in the cytoplasm and at the cell membrane; (5) cytoplasm only; and (6) no MUC1 expression detected.
Affiliation: Department of Breast and Endocrine Surgery, Nihon University School of Medicine, Tokyo, Japan.