Overexpression of chemokine receptor CXCR2 and ligand CXCL7 in liver metastases from colon cancer is correlated to shorter disease-free and overall survival.
Bottom Line: By multivariate analysis, CXCR2 and CXCL7 expressions are independent factors of overall and disease-free survival.CXCL7 was overexpressed close to significance, 0.40 (0.00-7.85) vs 0.15 (0.01-7.88), P = 0.12.Selective blockage of CXCR2/CXCL7 signalling pathways could provide new potential therapeutic opportunities.
Affiliation: Inserm, U837, Team-5 (Mucins, Epithelial Differentiation, and Carcinogenesis), Jean-Pierre Aubert Research Centre, Université Lille, France; Department of Digestive and Visceral Surgery, GHICL, Saint-Vincent de Paul Hospital, Lille, France.Show MeSH
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Mentions: We compared the median CXCR2 expression levels in the two subgroups of patients having received, or not received, a neoadjuvant chemotherapy regimen. The median CXCR2 expression was more than threefold higher in the treated group (n = 30) than in the control group (n = 21) (1.89 [0.02–50.92] vs 0.55 [0.07–3.22], respectively; P = 0.016) (Fig.2a). Median CXCL7 expression was nearly threefold higher in the treated group than in the control group (0.40 [0.00–7.85] vs 0.15 [0.01–7.88], respectively) but without reaching statistical significance (P = 0.127) (Fig.2b). Neoadjuvant chemotherapy did not impact the median CXCL8 expression level (Fig.2c). In addition, no significant difference was found between median CXCL2, CXCL6, and MIF expression levels between the two subgroups of patients. Also contrasting with our previous findings obtained with a series of 23 patients,7 we could not confirm an increase in CXCR4 expression in treated versus untreated patients with this larger series of 55 patients (Fig.2c).
Affiliation: Inserm, U837, Team-5 (Mucins, Epithelial Differentiation, and Carcinogenesis), Jean-Pierre Aubert Research Centre, Université Lille, France; Department of Digestive and Visceral Surgery, GHICL, Saint-Vincent de Paul Hospital, Lille, France.