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Quantifying maternally derived respiratory syncytial virus specific neutralising antibodies in a birth cohort from coastal Kenya.

Nyiro JU, Sande C, Mutunga M, Kiyuka PK, Munywoki PK, Scott JA, Nokes DJ - Vaccine (2015)

Bottom Line: There was no significant interaction between cord titre and rate of decay with age.The rate of decay varies widely by individual but is not related to titre at birth.RSV specific cord titres vary seasonally, presumably due to maternal boosting.

View Article: PubMed Central - PubMed

Affiliation: Kenya Medical Research Institute (KEMRI)-Wellcome Trust Research Programme, Centre for Geographic Medicine Research-Coast, Kilifi, Kenya. Electronic address: jnyiro@kemri-wellcome.org.

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Related in: MedlinePlus

Frequency distribution of maternally transferred RSV specific antibodies (log2 transformed PRNT titres) at birth for 100 infants born in Kilifi, Kenya. The overall mean (variance) and upper and lower quartile titres (log2PRNT) are shown.
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fig0005: Frequency distribution of maternally transferred RSV specific antibodies (log2 transformed PRNT titres) at birth for 100 infants born in Kilifi, Kenya. The overall mean (variance) and upper and lower quartile titres (log2PRNT) are shown.

Mentions: The frequency distribution of log-transformed PRNT titres for cord blood samples was approximately normal (Fig. 1) with mean concentration 10.6 (95% Confidence Interval (CI) 10.3–10.7, variance 1.28) and median of 10.6 (Interquartile Range (IQR) 9.95–11.4, 10th percentile 8.87 log2PRNT). The mean birth weight in kilograms of the participants in this study was 2.89 kg (SD: 0.49) and 19% were born with low birthweight <2.5 kg (mean: 2.16; SD: 0.21). Only 63 participants had data on gestational period. The mean gestation period in weeks was 38.6 (SD: 3.16). Of the 63 individuals with gestational data, 15(24%) were born prematurely i.e. <37weeks (mean 34.4; SD: 2.48). There was a significant difference in the cord blood neutralising antibody concentrations among the low birth weight, 9.9 log2PRNT compared to the normal weight 10.7log2PRNT (P = 0.02, t = −2.37) and between premature, 9.8 log2PRNT and not premature, 10.9 log2PRNT (P = 0.002, t = −3.18).


Quantifying maternally derived respiratory syncytial virus specific neutralising antibodies in a birth cohort from coastal Kenya.

Nyiro JU, Sande C, Mutunga M, Kiyuka PK, Munywoki PK, Scott JA, Nokes DJ - Vaccine (2015)

Frequency distribution of maternally transferred RSV specific antibodies (log2 transformed PRNT titres) at birth for 100 infants born in Kilifi, Kenya. The overall mean (variance) and upper and lower quartile titres (log2PRNT) are shown.
© Copyright Policy - CC BY
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4376380&req=5

fig0005: Frequency distribution of maternally transferred RSV specific antibodies (log2 transformed PRNT titres) at birth for 100 infants born in Kilifi, Kenya. The overall mean (variance) and upper and lower quartile titres (log2PRNT) are shown.
Mentions: The frequency distribution of log-transformed PRNT titres for cord blood samples was approximately normal (Fig. 1) with mean concentration 10.6 (95% Confidence Interval (CI) 10.3–10.7, variance 1.28) and median of 10.6 (Interquartile Range (IQR) 9.95–11.4, 10th percentile 8.87 log2PRNT). The mean birth weight in kilograms of the participants in this study was 2.89 kg (SD: 0.49) and 19% were born with low birthweight <2.5 kg (mean: 2.16; SD: 0.21). Only 63 participants had data on gestational period. The mean gestation period in weeks was 38.6 (SD: 3.16). Of the 63 individuals with gestational data, 15(24%) were born prematurely i.e. <37weeks (mean 34.4; SD: 2.48). There was a significant difference in the cord blood neutralising antibody concentrations among the low birth weight, 9.9 log2PRNT compared to the normal weight 10.7log2PRNT (P = 0.02, t = −2.37) and between premature, 9.8 log2PRNT and not premature, 10.9 log2PRNT (P = 0.002, t = −3.18).

Bottom Line: There was no significant interaction between cord titre and rate of decay with age.The rate of decay varies widely by individual but is not related to titre at birth.RSV specific cord titres vary seasonally, presumably due to maternal boosting.

View Article: PubMed Central - PubMed

Affiliation: Kenya Medical Research Institute (KEMRI)-Wellcome Trust Research Programme, Centre for Geographic Medicine Research-Coast, Kilifi, Kenya. Electronic address: jnyiro@kemri-wellcome.org.

Show MeSH
Related in: MedlinePlus