Quantifying maternally derived respiratory syncytial virus specific neutralising antibodies in a birth cohort from coastal Kenya.
Bottom Line: There was no significant interaction between cord titre and rate of decay with age.The rate of decay varies widely by individual but is not related to titre at birth.RSV specific cord titres vary seasonally, presumably due to maternal boosting.
Affiliation: Kenya Medical Research Institute (KEMRI)-Wellcome Trust Research Programme, Centre for Geographic Medicine Research-Coast, Kilifi, Kenya. Electronic address: email@example.com.Show MeSH
Related in: MedlinePlus
Mentions: The frequency distribution of log-transformed PRNT titres for cord blood samples was approximately normal (Fig. 1) with mean concentration 10.6 (95% Confidence Interval (CI) 10.3–10.7, variance 1.28) and median of 10.6 (Interquartile Range (IQR) 9.95–11.4, 10th percentile 8.87 log2PRNT). The mean birth weight in kilograms of the participants in this study was 2.89 kg (SD: 0.49) and 19% were born with low birthweight <2.5 kg (mean: 2.16; SD: 0.21). Only 63 participants had data on gestational period. The mean gestation period in weeks was 38.6 (SD: 3.16). Of the 63 individuals with gestational data, 15(24%) were born prematurely i.e. <37weeks (mean 34.4; SD: 2.48). There was a significant difference in the cord blood neutralising antibody concentrations among the low birth weight, 9.9 log2PRNT compared to the normal weight 10.7log2PRNT (P = 0.02, t = −2.37) and between premature, 9.8 log2PRNT and not premature, 10.9 log2PRNT (P = 0.002, t = −3.18).
Affiliation: Kenya Medical Research Institute (KEMRI)-Wellcome Trust Research Programme, Centre for Geographic Medicine Research-Coast, Kilifi, Kenya. Electronic address: firstname.lastname@example.org.