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Vitreous estrogen levels in patients with an idiopathic macular hole.

Inokuchi N, Ikeda T, Nakamura K, Morishita S, Fukumoto M, Kida T, Oku H - Clin Ophthalmol (2015)

Bottom Line: Estrogen, a female hormone, activates collagenase and might be associated with the pathogenesis of vitreoretinal collagen fiber disease.Thus, the vitreous E2 levels in the subjects with IMH were significantly higher than in the controls (P<0.05).The findings of this study suggest that E2 might be associated with the pathogenesis of IMH, but further investigation is needed to elucidate that association.

View Article: PubMed Central - PubMed

Affiliation: Inokuchi Eye Clinic, Suita-City Osaka, Japan.

ABSTRACT

Purpose: Estrogen, a female hormone, activates collagenase and might be associated with the pathogenesis of vitreoretinal collagen fiber disease. The purpose of the present study was to investigate the vitreous levels of estrone (E1) and estradiol (E2) in subjects with an idiopathic macular hole (IMH).

Methods: Vitreous samples were obtained from ten female patients with an IMH and from nine female patients with other retinal diseases (six with rhegmatogenous retinal detachment and three with age-related macular degeneration) as a control at the time of vitreous surgery. E1 and E2 levels in the vitreous samples were then determined using the Coat-A-Count(®) Estradiol Radioimmunoassay (RIA) Kit and the DSL-70 Estrone RIA Kit, respectively.

Results: The mean vitreous levels of E1 and E2 in the subjects with IMH were 1.83±2.00 pg/mL and 7.03±2.97 pg/mL, respectively, whereas in the control subjects they were 2.42±1.25 pg/mL and 4.90±2.90 pg/mL, respectively. Thus, the vitreous E2 levels in the subjects with IMH were significantly higher than in the controls (P<0.05).

Conclusion: The findings of this study suggest that E2 might be associated with the pathogenesis of IMH, but further investigation is needed to elucidate that association.

No MeSH data available.


Related in: MedlinePlus

Vitreous E2 levels.Note: The mean E2 levels in the vitreous samples obtained from the patients with an idiopathic macular hole were significantly higher than that in the vitreous samples obtained from the controls.Abbreviations: E2, estradiol; MH, patients with an idiopathic macular hole.
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f1-opth-9-549: Vitreous E2 levels.Note: The mean E2 levels in the vitreous samples obtained from the patients with an idiopathic macular hole were significantly higher than that in the vitreous samples obtained from the controls.Abbreviations: E2, estradiol; MH, patients with an idiopathic macular hole.

Mentions: The mean E2 levels in the vitreous samples obtained from the IMH patients was 7.03±2.97 pg/mL, which was significantly higher than the level in the vitreous samples obtained from the controls (4.90±2.90 pg/mL; P<0.05) (Figure 1). The mean E1 level in the vitreous samples obtained from the IMH patients was 1.83±2.00 pg/mL, which was not significantly different from that in the vitreous samples obtained from the controls (2.42±1.25 pg/mL) (Figure 2).


Vitreous estrogen levels in patients with an idiopathic macular hole.

Inokuchi N, Ikeda T, Nakamura K, Morishita S, Fukumoto M, Kida T, Oku H - Clin Ophthalmol (2015)

Vitreous E2 levels.Note: The mean E2 levels in the vitreous samples obtained from the patients with an idiopathic macular hole were significantly higher than that in the vitreous samples obtained from the controls.Abbreviations: E2, estradiol; MH, patients with an idiopathic macular hole.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4376308&req=5

f1-opth-9-549: Vitreous E2 levels.Note: The mean E2 levels in the vitreous samples obtained from the patients with an idiopathic macular hole were significantly higher than that in the vitreous samples obtained from the controls.Abbreviations: E2, estradiol; MH, patients with an idiopathic macular hole.
Mentions: The mean E2 levels in the vitreous samples obtained from the IMH patients was 7.03±2.97 pg/mL, which was significantly higher than the level in the vitreous samples obtained from the controls (4.90±2.90 pg/mL; P<0.05) (Figure 1). The mean E1 level in the vitreous samples obtained from the IMH patients was 1.83±2.00 pg/mL, which was not significantly different from that in the vitreous samples obtained from the controls (2.42±1.25 pg/mL) (Figure 2).

Bottom Line: Estrogen, a female hormone, activates collagenase and might be associated with the pathogenesis of vitreoretinal collagen fiber disease.Thus, the vitreous E2 levels in the subjects with IMH were significantly higher than in the controls (P<0.05).The findings of this study suggest that E2 might be associated with the pathogenesis of IMH, but further investigation is needed to elucidate that association.

View Article: PubMed Central - PubMed

Affiliation: Inokuchi Eye Clinic, Suita-City Osaka, Japan.

ABSTRACT

Purpose: Estrogen, a female hormone, activates collagenase and might be associated with the pathogenesis of vitreoretinal collagen fiber disease. The purpose of the present study was to investigate the vitreous levels of estrone (E1) and estradiol (E2) in subjects with an idiopathic macular hole (IMH).

Methods: Vitreous samples were obtained from ten female patients with an IMH and from nine female patients with other retinal diseases (six with rhegmatogenous retinal detachment and three with age-related macular degeneration) as a control at the time of vitreous surgery. E1 and E2 levels in the vitreous samples were then determined using the Coat-A-Count(®) Estradiol Radioimmunoassay (RIA) Kit and the DSL-70 Estrone RIA Kit, respectively.

Results: The mean vitreous levels of E1 and E2 in the subjects with IMH were 1.83±2.00 pg/mL and 7.03±2.97 pg/mL, respectively, whereas in the control subjects they were 2.42±1.25 pg/mL and 4.90±2.90 pg/mL, respectively. Thus, the vitreous E2 levels in the subjects with IMH were significantly higher than in the controls (P<0.05).

Conclusion: The findings of this study suggest that E2 might be associated with the pathogenesis of IMH, but further investigation is needed to elucidate that association.

No MeSH data available.


Related in: MedlinePlus