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Water-soluble L-cysteine-coated FePt nanoparticles as dual MRI/CT imaging contrast agent for glioma.

Liang S, Zhou Q, Wang M, Zhu Y, Wu Q, Yang X - Int J Nanomedicine (2015)

Bottom Line: The MRI and CT imaging ability of FePt-Cys NPs was evaluated using different gliomas cells (C6, SGH44, U251) as the model.Furthermore, the biocompatibility of the as-synthesized FePt-Cys NPs was evaluated using three different cell lines (ECV304, L929, and HEK293) as the model.The results showed that FePt-Cys NPs displayed excellent biocompatibility and good MRI/CT imaging ability, thereby indicating promising potential as a dual MRI/CT contrast agent for the diagnosis of brain malignant gliomas.

View Article: PubMed Central - PubMed

Affiliation: College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, People's Republic of China.

ABSTRACT
Nanoparticles (NPs) are advantageous for the delivery of diagnosis agents to brain tumors. In this study, we attempted to develop an L-cysteine coated FePt (FePt-Cys) NP as MRI/CT imaging contrast agent for the diagnosis of malignant gliomas. FePt-Cys NPs were synthesized through a co-reduction route, which was characterized by transmission electron microscopy, high-resolution transmission electron microscopy, powder X-ray diffraction, Fourier transform infrared spectroscopy, and dynamic light scattering. The MRI and CT imaging ability of FePt-Cys NPs was evaluated using different gliomas cells (C6, SGH44, U251) as the model. Furthermore, the biocompatibility of the as-synthesized FePt-Cys NPs was evaluated using three different cell lines (ECV304, L929, and HEK293) as the model. The results showed that FePt-Cys NPs displayed excellent biocompatibility and good MRI/CT imaging ability, thereby indicating promising potential as a dual MRI/CT contrast agent for the diagnosis of brain malignant gliomas.

No MeSH data available.


Related in: MedlinePlus

Magnetization hysteresis loop of the as-synthesized FePt-Cys NPs.Abbreviations: FePt-Cys, l-cysteine coated FePt; NPs, nanoparticles.
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f5-ijn-10-2325: Magnetization hysteresis loop of the as-synthesized FePt-Cys NPs.Abbreviations: FePt-Cys, l-cysteine coated FePt; NPs, nanoparticles.

Mentions: The magnetic property of the as-synthesized FePt-Cys NPs was measured by vibrating sample magnetometer at room temperature. Figure 5 shows the characteristic superparamagnetic curve of FePt-Cys NPs. The saturated mass magnetization value was~16.1 emu/g Fe, which was approximate to that of cysteamine-coated FePt NPs (12.3 emu/g Fe), but was lower than those of Fe2O3−, SiO2−, and tetraethylene glycol-coated FePt NPs.30–33 The magnetic property of FePt NPs is not only strongly correlated with the degree of chemical ordering of the alloy, but also influenced by the composition and surface coating of the alloy.44–46 The surface iron sites are the primary contributors to the magnetization in FePt. The strong bonding interaction between the surfactant and the surface iron sites results in the decrease of magnetization. For example, theoretical calculations showed that the charge is transferred to the surface iron sites from oleylamine and lowers the atomic magnetization by about 60% at the iron site in oleylamine-coated FePt NPs.44


Water-soluble L-cysteine-coated FePt nanoparticles as dual MRI/CT imaging contrast agent for glioma.

Liang S, Zhou Q, Wang M, Zhu Y, Wu Q, Yang X - Int J Nanomedicine (2015)

Magnetization hysteresis loop of the as-synthesized FePt-Cys NPs.Abbreviations: FePt-Cys, l-cysteine coated FePt; NPs, nanoparticles.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4376264&req=5

f5-ijn-10-2325: Magnetization hysteresis loop of the as-synthesized FePt-Cys NPs.Abbreviations: FePt-Cys, l-cysteine coated FePt; NPs, nanoparticles.
Mentions: The magnetic property of the as-synthesized FePt-Cys NPs was measured by vibrating sample magnetometer at room temperature. Figure 5 shows the characteristic superparamagnetic curve of FePt-Cys NPs. The saturated mass magnetization value was~16.1 emu/g Fe, which was approximate to that of cysteamine-coated FePt NPs (12.3 emu/g Fe), but was lower than those of Fe2O3−, SiO2−, and tetraethylene glycol-coated FePt NPs.30–33 The magnetic property of FePt NPs is not only strongly correlated with the degree of chemical ordering of the alloy, but also influenced by the composition and surface coating of the alloy.44–46 The surface iron sites are the primary contributors to the magnetization in FePt. The strong bonding interaction between the surfactant and the surface iron sites results in the decrease of magnetization. For example, theoretical calculations showed that the charge is transferred to the surface iron sites from oleylamine and lowers the atomic magnetization by about 60% at the iron site in oleylamine-coated FePt NPs.44

Bottom Line: The MRI and CT imaging ability of FePt-Cys NPs was evaluated using different gliomas cells (C6, SGH44, U251) as the model.Furthermore, the biocompatibility of the as-synthesized FePt-Cys NPs was evaluated using three different cell lines (ECV304, L929, and HEK293) as the model.The results showed that FePt-Cys NPs displayed excellent biocompatibility and good MRI/CT imaging ability, thereby indicating promising potential as a dual MRI/CT contrast agent for the diagnosis of brain malignant gliomas.

View Article: PubMed Central - PubMed

Affiliation: College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, People's Republic of China.

ABSTRACT
Nanoparticles (NPs) are advantageous for the delivery of diagnosis agents to brain tumors. In this study, we attempted to develop an L-cysteine coated FePt (FePt-Cys) NP as MRI/CT imaging contrast agent for the diagnosis of malignant gliomas. FePt-Cys NPs were synthesized through a co-reduction route, which was characterized by transmission electron microscopy, high-resolution transmission electron microscopy, powder X-ray diffraction, Fourier transform infrared spectroscopy, and dynamic light scattering. The MRI and CT imaging ability of FePt-Cys NPs was evaluated using different gliomas cells (C6, SGH44, U251) as the model. Furthermore, the biocompatibility of the as-synthesized FePt-Cys NPs was evaluated using three different cell lines (ECV304, L929, and HEK293) as the model. The results showed that FePt-Cys NPs displayed excellent biocompatibility and good MRI/CT imaging ability, thereby indicating promising potential as a dual MRI/CT contrast agent for the diagnosis of brain malignant gliomas.

No MeSH data available.


Related in: MedlinePlus