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Clinical significance of ALDH2 rs671 polymorphism in esophageal cancer: evidence from 31 case-control studies.

Zhao T, Wang C, Shen L, Gu D, Xu Z, Zhang X, Xu Y, Chen J - Onco Targets Ther (2015)

Bottom Line: The pooled odds ratio (OR) and the 95% confidence interval (CI) were calculated using a fixed or random-effects model.Although a protective effort was found in the rs671 homozygote comparison (AA/GG: OR=0.69; 95% CI=0.48-0.98), the heterozygote comparison was apparently associated with the risk of EC, particularly in the Chinese population ( OR=1.39; 95% CI=1.03-1.87).Taken together, insights from this study suggested an enhanced effect on the development of EC through a genetic-environmental interaction.

View Article: PubMed Central - PubMed

Affiliation: Department of Oncology, Nanjing First Hospital, Nanjing Medical University, Nanjing, People's Republic of China.

ABSTRACT

Background: Aldehyde dehydrogenase 2 (ALDH2), a critical enzyme for the detoxification of alcohol, is associated with many types of cancers. To verify the relationship of ALDH2 rs671 G>A polymorphism and esophageal cancer (EC), we performed a meta-analysis of a total of 31 published data including 8,510 patients and 16,197 controls.

Methods: The pooled odds ratio (OR) and the 95% confidence interval (CI) were calculated using a fixed or random-effects model. Heterogeneity (PH ), publication bias, and sensitivity analysis were also determined.

Results: Although a protective effort was found in the rs671 homozygote comparison (AA/GG: OR=0.69; 95% CI=0.48-0.98), the heterozygote comparison was apparently associated with the risk of EC, particularly in the Chinese population (

Ag/gg: OR=1.39; 95% CI=1.03-1.87). Alcohol consumption remarkably increased this risk, especially in the AG genotype. Drinking men with the AG genotype appeared to show a higher risk (

Ag/gg: OR=4.39; 95% CI=1.24-6.55) than drinking women.

Conclusion: The present meta-analysis provided advanced information regarding the association of the ALDH2 A>G polymorphism and EC. Taken together, insights from this study suggested an enhanced effect on the development of EC through a genetic-environmental interaction.

No MeSH data available.


Related in: MedlinePlus

Diagram of the relevant literature search and selection procedure.
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f1-ott-8-649: Diagram of the relevant literature search and selection procedure.

Mentions: Over 106 published literatures relevant to the search terms were obtained. After selection by title screening, clinical data quality check, and abstract review, a total of 31 eligible studies were selected (Figure 1), which contained 8,510 cases and 16,197 controls in the pooled analyses.14,20–49 The characteristics of selected studies with a case-control design were summarized in Table 1 – 15 from the People’s Republic of China, 14 from Japan, one from Thailand, and one from Cape Town. All of the EC cases were histologically and/or pathologically confirmed by licensed physiologists. The polymerase chain reaction–restriction fragment length polymorphism assay was performed in 16 of the 31 studies. In addition, controls were mainly matched based on sex and age, of which eleven studies were population-based and 20 studies were hospital-based. The distributions of genotypes in the controls of most studies were consistent with HWE, with the exception of seven studies23–29 that were tested by the sensitivity analyses.


Clinical significance of ALDH2 rs671 polymorphism in esophageal cancer: evidence from 31 case-control studies.

Zhao T, Wang C, Shen L, Gu D, Xu Z, Zhang X, Xu Y, Chen J - Onco Targets Ther (2015)

Diagram of the relevant literature search and selection procedure.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4376259&req=5

f1-ott-8-649: Diagram of the relevant literature search and selection procedure.
Mentions: Over 106 published literatures relevant to the search terms were obtained. After selection by title screening, clinical data quality check, and abstract review, a total of 31 eligible studies were selected (Figure 1), which contained 8,510 cases and 16,197 controls in the pooled analyses.14,20–49 The characteristics of selected studies with a case-control design were summarized in Table 1 – 15 from the People’s Republic of China, 14 from Japan, one from Thailand, and one from Cape Town. All of the EC cases were histologically and/or pathologically confirmed by licensed physiologists. The polymerase chain reaction–restriction fragment length polymorphism assay was performed in 16 of the 31 studies. In addition, controls were mainly matched based on sex and age, of which eleven studies were population-based and 20 studies were hospital-based. The distributions of genotypes in the controls of most studies were consistent with HWE, with the exception of seven studies23–29 that were tested by the sensitivity analyses.

Bottom Line: The pooled odds ratio (OR) and the 95% confidence interval (CI) were calculated using a fixed or random-effects model.Although a protective effort was found in the rs671 homozygote comparison (AA/GG: OR=0.69; 95% CI=0.48-0.98), the heterozygote comparison was apparently associated with the risk of EC, particularly in the Chinese population ( OR=1.39; 95% CI=1.03-1.87).Taken together, insights from this study suggested an enhanced effect on the development of EC through a genetic-environmental interaction.

View Article: PubMed Central - PubMed

Affiliation: Department of Oncology, Nanjing First Hospital, Nanjing Medical University, Nanjing, People's Republic of China.

ABSTRACT

Background: Aldehyde dehydrogenase 2 (ALDH2), a critical enzyme for the detoxification of alcohol, is associated with many types of cancers. To verify the relationship of ALDH2 rs671 G>A polymorphism and esophageal cancer (EC), we performed a meta-analysis of a total of 31 published data including 8,510 patients and 16,197 controls.

Methods: The pooled odds ratio (OR) and the 95% confidence interval (CI) were calculated using a fixed or random-effects model. Heterogeneity (PH ), publication bias, and sensitivity analysis were also determined.

Results: Although a protective effort was found in the rs671 homozygote comparison (AA/GG: OR=0.69; 95% CI=0.48-0.98), the heterozygote comparison was apparently associated with the risk of EC, particularly in the Chinese population (

Ag/gg: OR=1.39; 95% CI=1.03-1.87). Alcohol consumption remarkably increased this risk, especially in the AG genotype. Drinking men with the AG genotype appeared to show a higher risk (

Ag/gg: OR=4.39; 95% CI=1.24-6.55) than drinking women.

Conclusion: The present meta-analysis provided advanced information regarding the association of the ALDH2 A>G polymorphism and EC. Taken together, insights from this study suggested an enhanced effect on the development of EC through a genetic-environmental interaction.

No MeSH data available.


Related in: MedlinePlus