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Safety and efficacy of Qurse-e-istisqua in chronic hepatitis C infection: an exploratory study.

Rehan HS, Chopra D, Yadav M, Wardhan N, Manak S, Siddiqui KM, Aslam M - Indian J Pharmacol (2015 Jan-Feb)

Bottom Line: Q-e-I was well tolerated and showed anti-fibrotic activity.EVR, ETR and SVR suggested that Q-e-I do not have any anti-HCV activity.Early recovery in AST and inhibition of progress of fibrosis in Q-e-I group was probably due to the anti-inflammatory and antioxidant activity of its ingredients.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmacology, Lady Hardinge Medical College, New Delhi, India.

ABSTRACT

Background: Qurse-e-istisqua (Q-e-I), an Unani medicine commonly prescribed to treat liver disorders.

Objectives: To study efficacy and safety of Q-e-I in hepatitis C virus (HCV) infection.

Methods: In this randomized double-blind exploratory study, 60 naive patients of HCV infection were assigned to receive either interferonα2a (IFNα2a) (3 mIU, subcutaneous, thrice weekly), ribavirin (RBV) (1000 mg, orally, twice daily in divided doses) and placebo (n = 30) or IFNα2a, RBV and Q-e-I (5 g, orally, thrice daily in divided doses) (n = 30). HCV RNA levels, serum hyaluronic acid (SHA), ultrasound image scoring for fibrosis, liver and renal function test, prothrombin time, were done at the baseline and thereafter periodically.

Results: Early virologic response (EVR), end of treatment response (ETR) and sustained virologic response (SVR) were 90%, 96.6% and 90% in the control group and 86.6%, 90.0% and 83.3% in the treatment group. SHA level was lower in the treatment group at the end of the treatment as compared to the control group. Mean end of follow-up ultrasound image scoring for fibrosis in the control and the treatment group was 1.37 ± 0.07 and 1.22 ± 0.06 respectively. Aspartate aminotransferase (AST) levels were significantly lower in the treatment group than the control group at 1-month. Commonly observed adverse drug reactions included fever, hair fall, fatigue, anemia, and diarrhea.

Conclusion: Q-e-I was well tolerated and showed anti-fibrotic activity. EVR, ETR and SVR suggested that Q-e-I do not have any anti-HCV activity. Early recovery in AST and inhibition of progress of fibrosis in Q-e-I group was probably due to the anti-inflammatory and antioxidant activity of its ingredients.

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Related in: MedlinePlus

Serum alanine aminotransferase levels (mean ± standard error mean) baseline, 1-month, 3 months, end of treatment and at the end of follow-up. ***P<0.001 comparison within the groups, †P<0.05 comparison in between the groups
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Figure 6: Serum alanine aminotransferase levels (mean ± standard error mean) baseline, 1-month, 3 months, end of treatment and at the end of follow-up. ***P<0.001 comparison within the groups, †P<0.05 comparison in between the groups

Mentions: Within the groups significant improvement in aspartate aminotransferase (AST) (P < 0.01) and alanine aminotransferase (ALT) (P < 0.001) was observed at 1-month and till the end of the follow-up (P < 0.001) in the test group while in the control group significant improvement in AST [Figure 4] and ALT [Figure 5] levels was seen at 3 months (P < 0.001) and till the end of the follow-up. On comparing the two groups, the AST levels at end of 1-month were significantly lower in the test group. But ALT levels in the test group were insignificantly different from the control group. Significant improvement in alkaline phosphatase (ALP) [Figure 6] levels was seen in both the groups at the end of the treatment and also at the end of the follow-up. No significant difference was seen in the total bilirubin levels in both the groups [Figure 7].


Safety and efficacy of Qurse-e-istisqua in chronic hepatitis C infection: an exploratory study.

Rehan HS, Chopra D, Yadav M, Wardhan N, Manak S, Siddiqui KM, Aslam M - Indian J Pharmacol (2015 Jan-Feb)

Serum alanine aminotransferase levels (mean ± standard error mean) baseline, 1-month, 3 months, end of treatment and at the end of follow-up. ***P<0.001 comparison within the groups, †P<0.05 comparison in between the groups
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4375823&req=5

Figure 6: Serum alanine aminotransferase levels (mean ± standard error mean) baseline, 1-month, 3 months, end of treatment and at the end of follow-up. ***P<0.001 comparison within the groups, †P<0.05 comparison in between the groups
Mentions: Within the groups significant improvement in aspartate aminotransferase (AST) (P < 0.01) and alanine aminotransferase (ALT) (P < 0.001) was observed at 1-month and till the end of the follow-up (P < 0.001) in the test group while in the control group significant improvement in AST [Figure 4] and ALT [Figure 5] levels was seen at 3 months (P < 0.001) and till the end of the follow-up. On comparing the two groups, the AST levels at end of 1-month were significantly lower in the test group. But ALT levels in the test group were insignificantly different from the control group. Significant improvement in alkaline phosphatase (ALP) [Figure 6] levels was seen in both the groups at the end of the treatment and also at the end of the follow-up. No significant difference was seen in the total bilirubin levels in both the groups [Figure 7].

Bottom Line: Q-e-I was well tolerated and showed anti-fibrotic activity.EVR, ETR and SVR suggested that Q-e-I do not have any anti-HCV activity.Early recovery in AST and inhibition of progress of fibrosis in Q-e-I group was probably due to the anti-inflammatory and antioxidant activity of its ingredients.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmacology, Lady Hardinge Medical College, New Delhi, India.

ABSTRACT

Background: Qurse-e-istisqua (Q-e-I), an Unani medicine commonly prescribed to treat liver disorders.

Objectives: To study efficacy and safety of Q-e-I in hepatitis C virus (HCV) infection.

Methods: In this randomized double-blind exploratory study, 60 naive patients of HCV infection were assigned to receive either interferonα2a (IFNα2a) (3 mIU, subcutaneous, thrice weekly), ribavirin (RBV) (1000 mg, orally, twice daily in divided doses) and placebo (n = 30) or IFNα2a, RBV and Q-e-I (5 g, orally, thrice daily in divided doses) (n = 30). HCV RNA levels, serum hyaluronic acid (SHA), ultrasound image scoring for fibrosis, liver and renal function test, prothrombin time, were done at the baseline and thereafter periodically.

Results: Early virologic response (EVR), end of treatment response (ETR) and sustained virologic response (SVR) were 90%, 96.6% and 90% in the control group and 86.6%, 90.0% and 83.3% in the treatment group. SHA level was lower in the treatment group at the end of the treatment as compared to the control group. Mean end of follow-up ultrasound image scoring for fibrosis in the control and the treatment group was 1.37 ± 0.07 and 1.22 ± 0.06 respectively. Aspartate aminotransferase (AST) levels were significantly lower in the treatment group than the control group at 1-month. Commonly observed adverse drug reactions included fever, hair fall, fatigue, anemia, and diarrhea.

Conclusion: Q-e-I was well tolerated and showed anti-fibrotic activity. EVR, ETR and SVR suggested that Q-e-I do not have any anti-HCV activity. Early recovery in AST and inhibition of progress of fibrosis in Q-e-I group was probably due to the anti-inflammatory and antioxidant activity of its ingredients.

Show MeSH
Related in: MedlinePlus