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Retinoic acid and glycolic acid combination in the treatment of acne scars.

Chandrashekar BS, Ashwini KR, Vasanth V, Navale S - Indian Dermatol Online J (2015 Mar-Apr)

Bottom Line: Retinoic acid (RA) is said to improve acne scars and reduce postinflammatory hyperpigmentation while glycolic acid (GA) is known for its keratolytic properties and its ability to reduce atrophic acne scars.There are studies exploring the combined effect of retinaldehyde and GA combination with positive results while the efficacy of retinoic acid and GA (RAGA) combination remains unexplored.The differences in the scar grades were noted to assess the improvement.

View Article: PubMed Central - PubMed

Affiliation: Department of Dermatology, CUTIS, Academy of Cutaneous Sciences, Bengaluru, Karnataka, India.

ABSTRACT

Introduction: Acne is a prevalent condition in society affecting nearly 80-90% of adolescents often resulting in secondary damage in the form of scarring. Retinoic acid (RA) is said to improve acne scars and reduce postinflammatory hyperpigmentation while glycolic acid (GA) is known for its keratolytic properties and its ability to reduce atrophic acne scars. There are studies exploring the combined effect of retinaldehyde and GA combination with positive results while the efficacy of retinoic acid and GA (RAGA) combination remains unexplored.

Aim: The aim of this study remains to retrospectively assess the efficacy of RAGA combination on acne scars in patients previously treated for active acne.

Materials and methods: A retrospective assessment of 35 patients using topical RAGA combination on acne scars was done. The subjects were 17-34 years old and previously treated for active acne. Case records and photographs of each patient were assessed and the acne scars were graded as per Goodman and Baron's global scarring grading system (GSGS), before the start and after 12 weeks of RAGA treatment. The differences in the scar grades were noted to assess the improvement.

Results: At the end of 12 weeks, significant improvement in acne scars was noticed in 91.4% of the patients.

Conclusion: The RAGA combination shows efficacy in treating acne scars in the majority of patients, minimizing the need of procedural treatment for acne scars.

No MeSH data available.


Related in: MedlinePlus

(a) Picture showing postinflammatory hyperpigmentation as a sequelae to acne before starting retinoic acid and glycolic acid treatment (b) Photograph showing 3 points improvement in postinflammatory hyperpigmentation
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Figure 7: (a) Picture showing postinflammatory hyperpigmentation as a sequelae to acne before starting retinoic acid and glycolic acid treatment (b) Photograph showing 3 points improvement in postinflammatory hyperpigmentation

Mentions: Among macular pigmentary lesions, 20 patients showed a 3-point reduction in macular lesions [Figure 7a and 7b], while eight of them had a reduction of 2 points and 2 patients showed a reduction of 1 point. Overall 85.71% of the patients had an improvement in the appearance of their pigmented macules. The improvement is depicted in Figure 8 and Table 3. None of the patients complained of erythema or burning.


Retinoic acid and glycolic acid combination in the treatment of acne scars.

Chandrashekar BS, Ashwini KR, Vasanth V, Navale S - Indian Dermatol Online J (2015 Mar-Apr)

(a) Picture showing postinflammatory hyperpigmentation as a sequelae to acne before starting retinoic acid and glycolic acid treatment (b) Photograph showing 3 points improvement in postinflammatory hyperpigmentation
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4375771&req=5

Figure 7: (a) Picture showing postinflammatory hyperpigmentation as a sequelae to acne before starting retinoic acid and glycolic acid treatment (b) Photograph showing 3 points improvement in postinflammatory hyperpigmentation
Mentions: Among macular pigmentary lesions, 20 patients showed a 3-point reduction in macular lesions [Figure 7a and 7b], while eight of them had a reduction of 2 points and 2 patients showed a reduction of 1 point. Overall 85.71% of the patients had an improvement in the appearance of their pigmented macules. The improvement is depicted in Figure 8 and Table 3. None of the patients complained of erythema or burning.

Bottom Line: Retinoic acid (RA) is said to improve acne scars and reduce postinflammatory hyperpigmentation while glycolic acid (GA) is known for its keratolytic properties and its ability to reduce atrophic acne scars.There are studies exploring the combined effect of retinaldehyde and GA combination with positive results while the efficacy of retinoic acid and GA (RAGA) combination remains unexplored.The differences in the scar grades were noted to assess the improvement.

View Article: PubMed Central - PubMed

Affiliation: Department of Dermatology, CUTIS, Academy of Cutaneous Sciences, Bengaluru, Karnataka, India.

ABSTRACT

Introduction: Acne is a prevalent condition in society affecting nearly 80-90% of adolescents often resulting in secondary damage in the form of scarring. Retinoic acid (RA) is said to improve acne scars and reduce postinflammatory hyperpigmentation while glycolic acid (GA) is known for its keratolytic properties and its ability to reduce atrophic acne scars. There are studies exploring the combined effect of retinaldehyde and GA combination with positive results while the efficacy of retinoic acid and GA (RAGA) combination remains unexplored.

Aim: The aim of this study remains to retrospectively assess the efficacy of RAGA combination on acne scars in patients previously treated for active acne.

Materials and methods: A retrospective assessment of 35 patients using topical RAGA combination on acne scars was done. The subjects were 17-34 years old and previously treated for active acne. Case records and photographs of each patient were assessed and the acne scars were graded as per Goodman and Baron's global scarring grading system (GSGS), before the start and after 12 weeks of RAGA treatment. The differences in the scar grades were noted to assess the improvement.

Results: At the end of 12 weeks, significant improvement in acne scars was noticed in 91.4% of the patients.

Conclusion: The RAGA combination shows efficacy in treating acne scars in the majority of patients, minimizing the need of procedural treatment for acne scars.

No MeSH data available.


Related in: MedlinePlus