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Retinoic acid and glycolic acid combination in the treatment of acne scars.

Chandrashekar BS, Ashwini KR, Vasanth V, Navale S - Indian Dermatol Online J (2015 Mar-Apr)

Bottom Line: Retinoic acid (RA) is said to improve acne scars and reduce postinflammatory hyperpigmentation while glycolic acid (GA) is known for its keratolytic properties and its ability to reduce atrophic acne scars.There are studies exploring the combined effect of retinaldehyde and GA combination with positive results while the efficacy of retinoic acid and GA (RAGA) combination remains unexplored.The differences in the scar grades were noted to assess the improvement.

View Article: PubMed Central - PubMed

Affiliation: Department of Dermatology, CUTIS, Academy of Cutaneous Sciences, Bengaluru, Karnataka, India.

ABSTRACT

Introduction: Acne is a prevalent condition in society affecting nearly 80-90% of adolescents often resulting in secondary damage in the form of scarring. Retinoic acid (RA) is said to improve acne scars and reduce postinflammatory hyperpigmentation while glycolic acid (GA) is known for its keratolytic properties and its ability to reduce atrophic acne scars. There are studies exploring the combined effect of retinaldehyde and GA combination with positive results while the efficacy of retinoic acid and GA (RAGA) combination remains unexplored.

Aim: The aim of this study remains to retrospectively assess the efficacy of RAGA combination on acne scars in patients previously treated for active acne.

Materials and methods: A retrospective assessment of 35 patients using topical RAGA combination on acne scars was done. The subjects were 17-34 years old and previously treated for active acne. Case records and photographs of each patient were assessed and the acne scars were graded as per Goodman and Baron's global scarring grading system (GSGS), before the start and after 12 weeks of RAGA treatment. The differences in the scar grades were noted to assess the improvement.

Results: At the end of 12 weeks, significant improvement in acne scars was noticed in 91.4% of the patients.

Conclusion: The RAGA combination shows efficacy in treating acne scars in the majority of patients, minimizing the need of procedural treatment for acne scars.

No MeSH data available.


Related in: MedlinePlus

(a) Acne scars with global scarring grading system score of 6 before starting of retinoic acid and glycolic acid treatment (b) Acne scars after 12 weeks of retinoic acid and glycolic acid treatment showing mild improvement with a global scarring grading system score of 3
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Figure 1: (a) Acne scars with global scarring grading system score of 6 before starting of retinoic acid and glycolic acid treatment (b) Acne scars after 12 weeks of retinoic acid and glycolic acid treatment showing mild improvement with a global scarring grading system score of 3

Mentions: Of the 35 patients, three showed no improvement in scar grades at the end of 12 weeks, while 16 patients demonstrated a mild improvement in their scars that is, the acne scar grades reduced to up to 5 points [Figure 1a and b]. Thirteen patients had moderate improvement in their acne scars [Figure 2a and b], two had good improvement [Figure 3a and b] and one patient demonstrated 21 points reduction in the appearance of his acne scars and had very good improvement [Figure 4a and b]. The overall improvement in acne scars is shown graphically in Figures 5 and 6.


Retinoic acid and glycolic acid combination in the treatment of acne scars.

Chandrashekar BS, Ashwini KR, Vasanth V, Navale S - Indian Dermatol Online J (2015 Mar-Apr)

(a) Acne scars with global scarring grading system score of 6 before starting of retinoic acid and glycolic acid treatment (b) Acne scars after 12 weeks of retinoic acid and glycolic acid treatment showing mild improvement with a global scarring grading system score of 3
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4375771&req=5

Figure 1: (a) Acne scars with global scarring grading system score of 6 before starting of retinoic acid and glycolic acid treatment (b) Acne scars after 12 weeks of retinoic acid and glycolic acid treatment showing mild improvement with a global scarring grading system score of 3
Mentions: Of the 35 patients, three showed no improvement in scar grades at the end of 12 weeks, while 16 patients demonstrated a mild improvement in their scars that is, the acne scar grades reduced to up to 5 points [Figure 1a and b]. Thirteen patients had moderate improvement in their acne scars [Figure 2a and b], two had good improvement [Figure 3a and b] and one patient demonstrated 21 points reduction in the appearance of his acne scars and had very good improvement [Figure 4a and b]. The overall improvement in acne scars is shown graphically in Figures 5 and 6.

Bottom Line: Retinoic acid (RA) is said to improve acne scars and reduce postinflammatory hyperpigmentation while glycolic acid (GA) is known for its keratolytic properties and its ability to reduce atrophic acne scars.There are studies exploring the combined effect of retinaldehyde and GA combination with positive results while the efficacy of retinoic acid and GA (RAGA) combination remains unexplored.The differences in the scar grades were noted to assess the improvement.

View Article: PubMed Central - PubMed

Affiliation: Department of Dermatology, CUTIS, Academy of Cutaneous Sciences, Bengaluru, Karnataka, India.

ABSTRACT

Introduction: Acne is a prevalent condition in society affecting nearly 80-90% of adolescents often resulting in secondary damage in the form of scarring. Retinoic acid (RA) is said to improve acne scars and reduce postinflammatory hyperpigmentation while glycolic acid (GA) is known for its keratolytic properties and its ability to reduce atrophic acne scars. There are studies exploring the combined effect of retinaldehyde and GA combination with positive results while the efficacy of retinoic acid and GA (RAGA) combination remains unexplored.

Aim: The aim of this study remains to retrospectively assess the efficacy of RAGA combination on acne scars in patients previously treated for active acne.

Materials and methods: A retrospective assessment of 35 patients using topical RAGA combination on acne scars was done. The subjects were 17-34 years old and previously treated for active acne. Case records and photographs of each patient were assessed and the acne scars were graded as per Goodman and Baron's global scarring grading system (GSGS), before the start and after 12 weeks of RAGA treatment. The differences in the scar grades were noted to assess the improvement.

Results: At the end of 12 weeks, significant improvement in acne scars was noticed in 91.4% of the patients.

Conclusion: The RAGA combination shows efficacy in treating acne scars in the majority of patients, minimizing the need of procedural treatment for acne scars.

No MeSH data available.


Related in: MedlinePlus