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Bier spots: An uncommon cause of mottled skin.

Mahajan VK, Khatri G, Singh R, Chauhan PS, Mehta KS - Indian Dermatol Online J (2015 Mar-Apr)

View Article: PubMed Central - PubMed

Affiliation: Department of Dermatology, Venereology and Leprosy, Dr. R. P. Government Medical College, Kangra (Tanda), Himachal Pradesh, India.

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Sir, Bier spots represent a very uncommon pattern of vascular mottling often confused with pigmentary changes leading to unnecessary psychological distress... As the spots were asymptomatic, he became aware of these only two years ago... He was treated for pityriasis versicolor previously at a peripheral center without any benefit... His family and medical history was unremarkable... He was a nonsmoker, and did not consume alcohol... Examination revealed hypopigmented macular lesions having irregular borders with a background blanching erythema spread over the forearms and hands... Laboratory investigations including blood counts, erythrocyte sedimentation rate, serum biochemistry, antinuclear antibody, rheumatoid factor, coagulogram, and urinalysis revealed no abnormality... Histology of a forearm lesion showed no significant pathology except for dilated capillaries in the upper dermis [Figure 4]... Bier spots (syn: Angiospastic macules, physiologic anemic macules, exaggerated physiologic speckled mottling of skin) most commonly occur in young adults aged 20-40 years affecting females more often than males... The lesions become imperceptible on diascopy (akin to nevus anemicus), with limb elevation or after the tourniquet is removed... Nevertheless, it is imperative to differentiate the condition from hypopigmented macules of vitiligo, pityriasis alba, postinflammatory hypopigmentation, pityriasis versicolor and nevus anemicus/hypochromicus to avoid unnecessary treatment/distress... The pathogenesis of this uncommon condition remains obscure... Peyrot et al. considered these to be from a benign physiological response of small cutaneous vessels to venous hypertension or perhaps tissue hypoxia as a result of vasoconstriction of small vessels giving it a characteristic vascular pattern... However, laser Doppler velocimetry studies show that these red spots are caused by relative vasodilation with higher blood flow and vasoconstriction in the pale areas... Although dilated capillaries seen on histology in our patient appear to corroborate these features, the overall histopathologal patterns remain unmapped due to paucity of cases.

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Related in: MedlinePlus

Innumerable hypopigmented macular lesions with faint, irregular borders against blanching erythema in a mottled pattern over forearms and palms. Mottling is more marked over the palms
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Figure 1: Innumerable hypopigmented macular lesions with faint, irregular borders against blanching erythema in a mottled pattern over forearms and palms. Mottling is more marked over the palms

Mentions: Bier spots represent a very uncommon pattern of vascular mottling often confused with pigmentary changes leading to unnecessary psychological distress. Only few cases have been reported since its original description by Bier in 1898. This 28-year-old male of Tibetan origin presented with numerous, light coloured spots over his forearms and hands in a mottled pattern [Figure 1]. As the spots were asymptomatic, he became aware of these only two years ago. He was treated for pityriasis versicolor previously at a peripheral center without any benefit. His family and medical history was unremarkable. He was a nonsmoker, and did not consume alcohol. There was no drug history. Examination revealed hypopigmented macular lesions having irregular borders with a background blanching erythema spread over the forearms and hands. Lesions were more marked over palms and became prominent when his arms were in a dependent position [Figure 2], and disappeared on limb elevation [Figure 3]. Clinical examination of the abdomen, cardiovascular, central nervous and pulmonary systems, and skin over the trunk and lower extremities was normal. Laboratory investigations including blood counts, erythrocyte sedimentation rate, serum biochemistry, antinuclear antibody, rheumatoid factor, coagulogram, and urinalysis revealed no abnormality. Histology of a forearm lesion showed no significant pathology except for dilated capillaries in the upper dermis [Figure 4].


Bier spots: An uncommon cause of mottled skin.

Mahajan VK, Khatri G, Singh R, Chauhan PS, Mehta KS - Indian Dermatol Online J (2015 Mar-Apr)

Innumerable hypopigmented macular lesions with faint, irregular borders against blanching erythema in a mottled pattern over forearms and palms. Mottling is more marked over the palms
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4375760&req=5

Figure 1: Innumerable hypopigmented macular lesions with faint, irregular borders against blanching erythema in a mottled pattern over forearms and palms. Mottling is more marked over the palms
Mentions: Bier spots represent a very uncommon pattern of vascular mottling often confused with pigmentary changes leading to unnecessary psychological distress. Only few cases have been reported since its original description by Bier in 1898. This 28-year-old male of Tibetan origin presented with numerous, light coloured spots over his forearms and hands in a mottled pattern [Figure 1]. As the spots were asymptomatic, he became aware of these only two years ago. He was treated for pityriasis versicolor previously at a peripheral center without any benefit. His family and medical history was unremarkable. He was a nonsmoker, and did not consume alcohol. There was no drug history. Examination revealed hypopigmented macular lesions having irregular borders with a background blanching erythema spread over the forearms and hands. Lesions were more marked over palms and became prominent when his arms were in a dependent position [Figure 2], and disappeared on limb elevation [Figure 3]. Clinical examination of the abdomen, cardiovascular, central nervous and pulmonary systems, and skin over the trunk and lower extremities was normal. Laboratory investigations including blood counts, erythrocyte sedimentation rate, serum biochemistry, antinuclear antibody, rheumatoid factor, coagulogram, and urinalysis revealed no abnormality. Histology of a forearm lesion showed no significant pathology except for dilated capillaries in the upper dermis [Figure 4].

View Article: PubMed Central - PubMed

Affiliation: Department of Dermatology, Venereology and Leprosy, Dr. R. P. Government Medical College, Kangra (Tanda), Himachal Pradesh, India.

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

Sir, Bier spots represent a very uncommon pattern of vascular mottling often confused with pigmentary changes leading to unnecessary psychological distress... As the spots were asymptomatic, he became aware of these only two years ago... He was treated for pityriasis versicolor previously at a peripheral center without any benefit... His family and medical history was unremarkable... He was a nonsmoker, and did not consume alcohol... Examination revealed hypopigmented macular lesions having irregular borders with a background blanching erythema spread over the forearms and hands... Laboratory investigations including blood counts, erythrocyte sedimentation rate, serum biochemistry, antinuclear antibody, rheumatoid factor, coagulogram, and urinalysis revealed no abnormality... Histology of a forearm lesion showed no significant pathology except for dilated capillaries in the upper dermis [Figure 4]... Bier spots (syn: Angiospastic macules, physiologic anemic macules, exaggerated physiologic speckled mottling of skin) most commonly occur in young adults aged 20-40 years affecting females more often than males... The lesions become imperceptible on diascopy (akin to nevus anemicus), with limb elevation or after the tourniquet is removed... Nevertheless, it is imperative to differentiate the condition from hypopigmented macules of vitiligo, pityriasis alba, postinflammatory hypopigmentation, pityriasis versicolor and nevus anemicus/hypochromicus to avoid unnecessary treatment/distress... The pathogenesis of this uncommon condition remains obscure... Peyrot et al. considered these to be from a benign physiological response of small cutaneous vessels to venous hypertension or perhaps tissue hypoxia as a result of vasoconstriction of small vessels giving it a characteristic vascular pattern... However, laser Doppler velocimetry studies show that these red spots are caused by relative vasodilation with higher blood flow and vasoconstriction in the pale areas... Although dilated capillaries seen on histology in our patient appear to corroborate these features, the overall histopathologal patterns remain unmapped due to paucity of cases.

No MeSH data available.


Related in: MedlinePlus