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Chronic obstructive pulmonary disease severity is associated with severe pneumonia.

Eom JS, Song WJ, Yoo H, Jeong BH, Lee HY, Koh WJ, Jeon K, Park HY - Ann Thorac Med (2015 Apr-Jun)

Bottom Line: Patients with hospital-acquired pneumonia and those with an immunocompromised status were excluded.Multivariate logistic regression analysis revealed that the severity of airflow limitation [odds ratio (OR), 2.751; 95% confidence interval (CI), 1.074-7.050; P = 0.035] and the presence of emphysema on a chest CT scan (OR, 3.366; 95% CI, 1.104-10.265; P = 0.033) were independently associated with severe pneumonia in patients with COPD.The severity of COPD including the airflow limitation grade and the presence of pulmonary emphysema were independently associated with the development of severe pneumonia.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, Pusan National University School of Medicine, Busan, Korea ; Biomedical Research Institute, Pusan National University Hospital, Busan, Korea.

ABSTRACT

Context: Chronic obstructive pulmonary disease (COPD) is a heterogeneous disorder, and various aspects of COPD may be associated with the severity of pneumonia in such patients.

Aims: We examined the risk factors associated with severe pneumonia in a COPD population.

Materials and methods: We performed a retrospective observational study using a prospectively collected database of pneumonia patients who were admitted to our hospital through emergency department between 2008 and 2012. Patients with hospital-acquired pneumonia and those with an immunocompromised status were excluded.

Results: Of 148 pneumonia patients with COPD for whom chest computed tomography (CT) scans were available, 106 (71.6%) and 42 (28.4%) were classified as non-severe and severe pneumonia, respectively. Multivariate logistic regression analysis revealed that the severity of airflow limitation [odds ratio (OR), 2.751; 95% confidence interval (CI), 1.074-7.050; P = 0.035] and the presence of emphysema on a chest CT scan (OR, 3.366; 95% CI, 1.104-10.265; P = 0.033) were independently associated with severe pneumonia in patients with COPD.

Conclusions: The severity of COPD including the airflow limitation grade and the presence of pulmonary emphysema were independently associated with the development of severe pneumonia.

No MeSH data available.


Related in: MedlinePlus

Study flow diagram
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Figure 1: Study flow diagram

Mentions: Thus, 1,498 cases of pneumonia were included in the present study initially, among whom 216 had both pneumonia and COPD (confirmed by spirometry performed either prior to admission or after recovery from pneumonia). If a patient was admitted more than once for pneumonia during the study period, data from only the first admission were analyzed. Penultimately, we included data from 159 COPD patients with pneumonia. Eleven further patients were excluded, because chest CT scans had not been performed within 1 year before or after pneumonia. Thus, a final total of 148 patients were included in the present study [Figure 1].


Chronic obstructive pulmonary disease severity is associated with severe pneumonia.

Eom JS, Song WJ, Yoo H, Jeong BH, Lee HY, Koh WJ, Jeon K, Park HY - Ann Thorac Med (2015 Apr-Jun)

Study flow diagram
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4375738&req=5

Figure 1: Study flow diagram
Mentions: Thus, 1,498 cases of pneumonia were included in the present study initially, among whom 216 had both pneumonia and COPD (confirmed by spirometry performed either prior to admission or after recovery from pneumonia). If a patient was admitted more than once for pneumonia during the study period, data from only the first admission were analyzed. Penultimately, we included data from 159 COPD patients with pneumonia. Eleven further patients were excluded, because chest CT scans had not been performed within 1 year before or after pneumonia. Thus, a final total of 148 patients were included in the present study [Figure 1].

Bottom Line: Patients with hospital-acquired pneumonia and those with an immunocompromised status were excluded.Multivariate logistic regression analysis revealed that the severity of airflow limitation [odds ratio (OR), 2.751; 95% confidence interval (CI), 1.074-7.050; P = 0.035] and the presence of emphysema on a chest CT scan (OR, 3.366; 95% CI, 1.104-10.265; P = 0.033) were independently associated with severe pneumonia in patients with COPD.The severity of COPD including the airflow limitation grade and the presence of pulmonary emphysema were independently associated with the development of severe pneumonia.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, Pusan National University School of Medicine, Busan, Korea ; Biomedical Research Institute, Pusan National University Hospital, Busan, Korea.

ABSTRACT

Context: Chronic obstructive pulmonary disease (COPD) is a heterogeneous disorder, and various aspects of COPD may be associated with the severity of pneumonia in such patients.

Aims: We examined the risk factors associated with severe pneumonia in a COPD population.

Materials and methods: We performed a retrospective observational study using a prospectively collected database of pneumonia patients who were admitted to our hospital through emergency department between 2008 and 2012. Patients with hospital-acquired pneumonia and those with an immunocompromised status were excluded.

Results: Of 148 pneumonia patients with COPD for whom chest computed tomography (CT) scans were available, 106 (71.6%) and 42 (28.4%) were classified as non-severe and severe pneumonia, respectively. Multivariate logistic regression analysis revealed that the severity of airflow limitation [odds ratio (OR), 2.751; 95% confidence interval (CI), 1.074-7.050; P = 0.035] and the presence of emphysema on a chest CT scan (OR, 3.366; 95% CI, 1.104-10.265; P = 0.033) were independently associated with severe pneumonia in patients with COPD.

Conclusions: The severity of COPD including the airflow limitation grade and the presence of pulmonary emphysema were independently associated with the development of severe pneumonia.

No MeSH data available.


Related in: MedlinePlus