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Prognostic significance and clinicopathological features of hypoxic inducible factor-2alpha expression in hepatocellular carcinoma.

Yao Q, Lv Y, Pan T, Liu Y, Ma J, Xu G - Saudi Med J (2015)

Bottom Line: All of the patients came from China.The results indicated that the association between HIF-2α expression and prognostic values in HCC was inconspicuous, while the expression of HIF-2α was significantly associated with capsule infiltration, vein invasion, and histological grade.Expression of HIF-2α was associated with invasion and metastasis in HCC, but did not have a distinct significance in prognosis, according to the limited evidence.

View Article: PubMed Central - PubMed

Affiliation: Department of Hepatic Surgery, Anhui Provincial Hospital, Hefei, Anhui, China. E-mail. yaoqiyang2014@sina.com.

ABSTRACT

Objectives: To assess the association between hypoxic inducible factor-2alpha (HIF-2α) and hepatocellular carcinoma (HCC) by meta-analysis.

Methods: This study was carried out at Anhui Province Hospital, Hefei, Anhui, China in February 2014. We searched various databases for studies published in English or Chinese up to February 28, 2014. The hazard ratio for overall survival and analyzed odds ratio were combined to evaluate the clinicopathological features of HIF-2α expression in HCC.

Results: A total of 7 eligible studies comprising 1066 patients with HCC were identified after our full assessment according to inclusion criteria. All of the patients came from China. The results indicated that the association between HIF-2α expression and prognostic values in HCC was inconspicuous, while the expression of HIF-2α was significantly associated with capsule infiltration, vein invasion, and histological grade.

Conclusion: Expression of HIF-2α was associated with invasion and metastasis in HCC, but did not have a distinct significance in prognosis, according to the limited evidence. However, high quality, large sample size, and controlled trials are required.

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Related in: MedlinePlus

The association of hypoxic inducible factor-2alpha expression with overall survival in hepatocellular carcinoma. HR - hazard ratio
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Figure 2: The association of hypoxic inducible factor-2alpha expression with overall survival in hepatocellular carcinoma. HR - hazard ratio

Mentions: By assuming the heterogeneity between primary studies, we meta-analyzed the data in a random-effects model. Five studies were included in this meta-analysis to assess the association of HIF-2α expression with OS (Figure 2). The pooled HR was 1.640, but 95% CI was 0.648 to 4.151. Then we randomly removed one of the studies and combined the HR. The results showed that the HRs ranged from 1.374 (95% CI: 0.495-3.815) to 2.129 (95% CI: 0.693-6.544), which suggests that the difference between expression of HIF-2α and OS in patients with HCC was not statistically significant. There was no evidence of publication bias on OS using Begg’s test (p=0.881).


Prognostic significance and clinicopathological features of hypoxic inducible factor-2alpha expression in hepatocellular carcinoma.

Yao Q, Lv Y, Pan T, Liu Y, Ma J, Xu G - Saudi Med J (2015)

The association of hypoxic inducible factor-2alpha expression with overall survival in hepatocellular carcinoma. HR - hazard ratio
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4375693&req=5

Figure 2: The association of hypoxic inducible factor-2alpha expression with overall survival in hepatocellular carcinoma. HR - hazard ratio
Mentions: By assuming the heterogeneity between primary studies, we meta-analyzed the data in a random-effects model. Five studies were included in this meta-analysis to assess the association of HIF-2α expression with OS (Figure 2). The pooled HR was 1.640, but 95% CI was 0.648 to 4.151. Then we randomly removed one of the studies and combined the HR. The results showed that the HRs ranged from 1.374 (95% CI: 0.495-3.815) to 2.129 (95% CI: 0.693-6.544), which suggests that the difference between expression of HIF-2α and OS in patients with HCC was not statistically significant. There was no evidence of publication bias on OS using Begg’s test (p=0.881).

Bottom Line: All of the patients came from China.The results indicated that the association between HIF-2α expression and prognostic values in HCC was inconspicuous, while the expression of HIF-2α was significantly associated with capsule infiltration, vein invasion, and histological grade.Expression of HIF-2α was associated with invasion and metastasis in HCC, but did not have a distinct significance in prognosis, according to the limited evidence.

View Article: PubMed Central - PubMed

Affiliation: Department of Hepatic Surgery, Anhui Provincial Hospital, Hefei, Anhui, China. E-mail. yaoqiyang2014@sina.com.

ABSTRACT

Objectives: To assess the association between hypoxic inducible factor-2alpha (HIF-2α) and hepatocellular carcinoma (HCC) by meta-analysis.

Methods: This study was carried out at Anhui Province Hospital, Hefei, Anhui, China in February 2014. We searched various databases for studies published in English or Chinese up to February 28, 2014. The hazard ratio for overall survival and analyzed odds ratio were combined to evaluate the clinicopathological features of HIF-2α expression in HCC.

Results: A total of 7 eligible studies comprising 1066 patients with HCC were identified after our full assessment according to inclusion criteria. All of the patients came from China. The results indicated that the association between HIF-2α expression and prognostic values in HCC was inconspicuous, while the expression of HIF-2α was significantly associated with capsule infiltration, vein invasion, and histological grade.

Conclusion: Expression of HIF-2α was associated with invasion and metastasis in HCC, but did not have a distinct significance in prognosis, according to the limited evidence. However, high quality, large sample size, and controlled trials are required.

Show MeSH
Related in: MedlinePlus