Limits...
Prognostic significance and clinicopathological features of hypoxic inducible factor-2alpha expression in hepatocellular carcinoma.

Yao Q, Lv Y, Pan T, Liu Y, Ma J, Xu G - Saudi Med J (2015)

Bottom Line: All of the patients came from China.The results indicated that the association between HIF-2α expression and prognostic values in HCC was inconspicuous, while the expression of HIF-2α was significantly associated with capsule infiltration, vein invasion, and histological grade.Expression of HIF-2α was associated with invasion and metastasis in HCC, but did not have a distinct significance in prognosis, according to the limited evidence.

View Article: PubMed Central - PubMed

Affiliation: Department of Hepatic Surgery, Anhui Provincial Hospital, Hefei, Anhui, China. E-mail. yaoqiyang2014@sina.com.

ABSTRACT

Objectives: To assess the association between hypoxic inducible factor-2alpha (HIF-2α) and hepatocellular carcinoma (HCC) by meta-analysis.

Methods: This study was carried out at Anhui Province Hospital, Hefei, Anhui, China in February 2014. We searched various databases for studies published in English or Chinese up to February 28, 2014. The hazard ratio for overall survival and analyzed odds ratio were combined to evaluate the clinicopathological features of HIF-2α expression in HCC.

Results: A total of 7 eligible studies comprising 1066 patients with HCC were identified after our full assessment according to inclusion criteria. All of the patients came from China. The results indicated that the association between HIF-2α expression and prognostic values in HCC was inconspicuous, while the expression of HIF-2α was significantly associated with capsule infiltration, vein invasion, and histological grade.

Conclusion: Expression of HIF-2α was associated with invasion and metastasis in HCC, but did not have a distinct significance in prognosis, according to the limited evidence. However, high quality, large sample size, and controlled trials are required.

Show MeSH

Related in: MedlinePlus

Study flow chart of data selection of 1103 records identified through database selection. HCC - hepatocellular carcinoma. CBM - Chinese Biological Medicine, CNKI - China National Knowledge Infrastructure
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4375693&req=5

Figure 1: Study flow chart of data selection of 1103 records identified through database selection. HCC - hepatocellular carcinoma. CBM - Chinese Biological Medicine, CNKI - China National Knowledge Infrastructure

Mentions: Study identification and quality. We identified 1103 potentially relevant studies, and 1095 of them were excluded from analysis (Figure 1) after careful extraction. As a result, 7 studies9-15 were finally included in the meta-analysis, and coincidentally they all derived from China. From these 7 studies, 1066 HCC patients were retrospectively analyzed, and all the tissue samples were examined using IHC.


Prognostic significance and clinicopathological features of hypoxic inducible factor-2alpha expression in hepatocellular carcinoma.

Yao Q, Lv Y, Pan T, Liu Y, Ma J, Xu G - Saudi Med J (2015)

Study flow chart of data selection of 1103 records identified through database selection. HCC - hepatocellular carcinoma. CBM - Chinese Biological Medicine, CNKI - China National Knowledge Infrastructure
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4375693&req=5

Figure 1: Study flow chart of data selection of 1103 records identified through database selection. HCC - hepatocellular carcinoma. CBM - Chinese Biological Medicine, CNKI - China National Knowledge Infrastructure
Mentions: Study identification and quality. We identified 1103 potentially relevant studies, and 1095 of them were excluded from analysis (Figure 1) after careful extraction. As a result, 7 studies9-15 were finally included in the meta-analysis, and coincidentally they all derived from China. From these 7 studies, 1066 HCC patients were retrospectively analyzed, and all the tissue samples were examined using IHC.

Bottom Line: All of the patients came from China.The results indicated that the association between HIF-2α expression and prognostic values in HCC was inconspicuous, while the expression of HIF-2α was significantly associated with capsule infiltration, vein invasion, and histological grade.Expression of HIF-2α was associated with invasion and metastasis in HCC, but did not have a distinct significance in prognosis, according to the limited evidence.

View Article: PubMed Central - PubMed

Affiliation: Department of Hepatic Surgery, Anhui Provincial Hospital, Hefei, Anhui, China. E-mail. yaoqiyang2014@sina.com.

ABSTRACT

Objectives: To assess the association between hypoxic inducible factor-2alpha (HIF-2α) and hepatocellular carcinoma (HCC) by meta-analysis.

Methods: This study was carried out at Anhui Province Hospital, Hefei, Anhui, China in February 2014. We searched various databases for studies published in English or Chinese up to February 28, 2014. The hazard ratio for overall survival and analyzed odds ratio were combined to evaluate the clinicopathological features of HIF-2α expression in HCC.

Results: A total of 7 eligible studies comprising 1066 patients with HCC were identified after our full assessment according to inclusion criteria. All of the patients came from China. The results indicated that the association between HIF-2α expression and prognostic values in HCC was inconspicuous, while the expression of HIF-2α was significantly associated with capsule infiltration, vein invasion, and histological grade.

Conclusion: Expression of HIF-2α was associated with invasion and metastasis in HCC, but did not have a distinct significance in prognosis, according to the limited evidence. However, high quality, large sample size, and controlled trials are required.

Show MeSH
Related in: MedlinePlus