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Efficacy of Xuebijing for coagulopathy in patients with sepsis.

Hou SY, Feng XH, Lin CL, Tan YF - Saudi Med J (2015)

Bottom Line: We conducted this meta-analysis in The People's Hospital of Liaoning Province, Shenyang, China between December 2013 and May 2014.Compared with placebo, XBJ injection significantly improved platelets (mean differences [MD] = 42.14, 95% confidence interval [CI]: 22.42 - 61.86, p<0.00001), shortened the activated partial thromboplastin time (MD = -4.81, 95% CI: -7.86 - [-1.76], p=0.002), shortened the prothrombin time (MD = -2.33, 95% CI: -4.15 - [-0.51], p=0.01), and shortened the thrombin time (MD = -2.05, 95% CI: -3.52 - [-0.58], p=0.006).However, no significant difference was found between the XBJ injection and the placebo group for fibrinogen (MD = 0.21, 95% CI: -0.38 - 0.81, p=0.48).

View Article: PubMed Central - PubMed

Affiliation: Department of Intensive Care Unit, The People's Hospital of Liaoning Province, No. 33, Wenyi Road, Shenhe District, Shenyang 110022, Liaoning, China. E-mail. siyuan_0525@163.com.

ABSTRACT

Objectives: To provide evidence of the clinical efficacy of Xuebijing (XBJ) on blood coagulation in patients with sepsis.

Methods: We conducted this meta-analysis in The People's Hospital of Liaoning Province, Shenyang, China between December 2013 and May 2014. We searched a number of databases for relevant randomized controlled trials (RCTs) published before December 2013 using the keywords 'Xuebijing', 'coagulation' and 'sepsis'. Statistical analysis was performed with Review Manager 5.2 from the Cochrane Collaboration.

Results: Fourteen RCTs involving 867 patients were included. Compared with placebo, XBJ injection significantly improved platelets (mean differences [MD] = 42.14, 95% confidence interval [CI]: 22.42 - 61.86, p<0.00001), shortened the activated partial thromboplastin time (MD = -4.81, 95% CI: -7.86 - [-1.76], p=0.002), shortened the prothrombin time (MD = -2.33, 95% CI: -4.15 - [-0.51], p=0.01), and shortened the thrombin time (MD = -2.05, 95% CI: -3.52 - [-0.58], p=0.006). However, no significant difference was found between the XBJ injection and the placebo group for fibrinogen (MD = 0.21, 95% CI: -0.38 - 0.81, p=0.48).

Conclusion: Xuebijing injection may improve coagulopathy in patients with sepsis. High-quality and large sample clinical trials are needed for confirmation.

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Related in: MedlinePlus

Meta-analysis of platelet change of Xuebijing injection for sepsis. IV - inverse variance, CI - confidence interval
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Figure 1: Meta-analysis of platelet change of Xuebijing injection for sepsis. IV - inverse variance, CI - confidence interval

Mentions: The results of meta-analysis showed that XBJ injection can significantly improve PLT (MD = 42.14, 95% CI: 22.42 - 61.86, p<0.00001, Figure 1), shorten the APTT (MD = -4.81, 95% CI: -7.86 - [-1.76], p=0.002, Figure 2), shorten the PT (MD = -2.33, 95% CI: -4.15 - [-0.51], p=0.01, Figure 3), shorten the TT (MD = -2.05, 95% CI: -3.52 - [-0.58], p=0.006, Figure 4). However, no significant difference was found between the Xuebijing injection and the placebo group in FIB change (MD = 0.21, 95% CI: -0.38 - 0.81, p=0.48, Figure 5).


Efficacy of Xuebijing for coagulopathy in patients with sepsis.

Hou SY, Feng XH, Lin CL, Tan YF - Saudi Med J (2015)

Meta-analysis of platelet change of Xuebijing injection for sepsis. IV - inverse variance, CI - confidence interval
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4375692&req=5

Figure 1: Meta-analysis of platelet change of Xuebijing injection for sepsis. IV - inverse variance, CI - confidence interval
Mentions: The results of meta-analysis showed that XBJ injection can significantly improve PLT (MD = 42.14, 95% CI: 22.42 - 61.86, p<0.00001, Figure 1), shorten the APTT (MD = -4.81, 95% CI: -7.86 - [-1.76], p=0.002, Figure 2), shorten the PT (MD = -2.33, 95% CI: -4.15 - [-0.51], p=0.01, Figure 3), shorten the TT (MD = -2.05, 95% CI: -3.52 - [-0.58], p=0.006, Figure 4). However, no significant difference was found between the Xuebijing injection and the placebo group in FIB change (MD = 0.21, 95% CI: -0.38 - 0.81, p=0.48, Figure 5).

Bottom Line: We conducted this meta-analysis in The People's Hospital of Liaoning Province, Shenyang, China between December 2013 and May 2014.Compared with placebo, XBJ injection significantly improved platelets (mean differences [MD] = 42.14, 95% confidence interval [CI]: 22.42 - 61.86, p<0.00001), shortened the activated partial thromboplastin time (MD = -4.81, 95% CI: -7.86 - [-1.76], p=0.002), shortened the prothrombin time (MD = -2.33, 95% CI: -4.15 - [-0.51], p=0.01), and shortened the thrombin time (MD = -2.05, 95% CI: -3.52 - [-0.58], p=0.006).However, no significant difference was found between the XBJ injection and the placebo group for fibrinogen (MD = 0.21, 95% CI: -0.38 - 0.81, p=0.48).

View Article: PubMed Central - PubMed

Affiliation: Department of Intensive Care Unit, The People's Hospital of Liaoning Province, No. 33, Wenyi Road, Shenhe District, Shenyang 110022, Liaoning, China. E-mail. siyuan_0525@163.com.

ABSTRACT

Objectives: To provide evidence of the clinical efficacy of Xuebijing (XBJ) on blood coagulation in patients with sepsis.

Methods: We conducted this meta-analysis in The People's Hospital of Liaoning Province, Shenyang, China between December 2013 and May 2014. We searched a number of databases for relevant randomized controlled trials (RCTs) published before December 2013 using the keywords 'Xuebijing', 'coagulation' and 'sepsis'. Statistical analysis was performed with Review Manager 5.2 from the Cochrane Collaboration.

Results: Fourteen RCTs involving 867 patients were included. Compared with placebo, XBJ injection significantly improved platelets (mean differences [MD] = 42.14, 95% confidence interval [CI]: 22.42 - 61.86, p<0.00001), shortened the activated partial thromboplastin time (MD = -4.81, 95% CI: -7.86 - [-1.76], p=0.002), shortened the prothrombin time (MD = -2.33, 95% CI: -4.15 - [-0.51], p=0.01), and shortened the thrombin time (MD = -2.05, 95% CI: -3.52 - [-0.58], p=0.006). However, no significant difference was found between the XBJ injection and the placebo group for fibrinogen (MD = 0.21, 95% CI: -0.38 - 0.81, p=0.48).

Conclusion: Xuebijing injection may improve coagulopathy in patients with sepsis. High-quality and large sample clinical trials are needed for confirmation.

Show MeSH
Related in: MedlinePlus