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T1rho MRI and CSF biomarkers in diagnosis of Alzheimer's disease.

Haris M, Yadav SK, Rizwan A, Singh A, Cai K, Kaura D, Wang E, Davatzikos C, Trojanowski JQ, Melhem ER, Marincola FM, Borthakur A - Neuroimage Clin (2015)

Bottom Line: On receiver operating characteristic analysis T1ρ showed higher sensitivity while CSF biomarkers showed greater specificity in delineating MCI and AD from controls.No significant correlation between T1ρ and CSF biomarkers, between T1ρ and age, and between CSF biomarkers and age was observed.Furthermore, disease progression form MCI to AD might be easily tracked using these two parameters in combination.

View Article: PubMed Central - PubMed

Affiliation: Research Branch, Sidra Medical and Research Center, Doha, Qatar ; Center for Magnetic Resonance and Optical Imaging, Department of Radiology, University of Pennsylvania, Philadelphia, PA, USA.

ABSTRACT
In the current study, we have evaluated the performance of magnetic resonance (MR) T1rho (T1ρ) imaging and CSF biomarkers (T-tau, P-tau and Aβ-42) in characterization of Alzheimer's disease (AD) patients from mild cognitive impairment (MCI) and control subjects. With informed consent, AD (n = 27), MCI (n = 17) and control (n = 17) subjects underwent a standardized clinical assessment and brain MRI on a 1.5-T clinical-scanner. T1ρ images were obtained at four different spin-lock pulse duration (10, 20, 30 and 40 ms). T1ρ maps were generated by pixel-wise fitting of signal intensity as a function of the spin-lock pulse duration. T1ρ values from gray matter (GM) and white matter (WM) of medial temporal lobe were calculated. The binary logistic regression using T1ρ and CSF biomarkers as variables was performed to classify each group. T1ρ was able to predict 77.3% controls and 40.0% MCI while CSF biomarkers predicted 81.8% controls and 46.7% MCI. T1ρ and CSF biomarkers in combination predicted 86.4% controls and 66.7% MCI. When comparing controls with AD, T1ρ predicted 68.2% controls and 73.9% AD, while CSF biomarkers predicted 77.3% controls and 78.3% for AD. Combination of T1ρ and CSF biomarkers improved the prediction rate to 81.8% for controls and 82.6% for AD. Similarly, on comparing MCI with AD, T1ρ predicted 35.3% MCI and 81.9% AD, whereas CSF biomarkers predicted 53.3% MCI and 83.0% AD. Collectively CSF biomarkers and T1ρ were able to predict 59.3% MCI and 84.6% AD. On receiver operating characteristic analysis T1ρ showed higher sensitivity while CSF biomarkers showed greater specificity in delineating MCI and AD from controls. No significant correlation between T1ρ and CSF biomarkers, between T1ρ and age, and between CSF biomarkers and age was observed. The combined use of T1ρ and CSF biomarkers have promise to improve the early and specific diagnosis of AD. Furthermore, disease progression form MCI to AD might be easily tracked using these two parameters in combination.

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Related in: MedlinePlus

T1rho (T1ρ) contrast from medial temporal lobe overlaid on anatomic fluid attenuated T1ρ weighted images of control (A), medial cognitive impairment (MCI, B), and Alzheimer's disease (AD, C) patients. A progressive increase in T1ρ contrast in medial temporal lobe (MTL) region was observed from control to MCI to AD. No T1ρ contrast from CSF was depicted.
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f0005: T1rho (T1ρ) contrast from medial temporal lobe overlaid on anatomic fluid attenuated T1ρ weighted images of control (A), medial cognitive impairment (MCI, B), and Alzheimer's disease (AD, C) patients. A progressive increase in T1ρ contrast in medial temporal lobe (MTL) region was observed from control to MCI to AD. No T1ρ contrast from CSF was depicted.

Mentions: Fig. 1 shows the overlaid T1ρ maps from MTL region (in color) on fluid-attenuated brain T1ρ weighted images of control, MCI, and AD patient. Pixels with higher T1ρ (red) are more prominent in MTL of AD patient. Increased sulcal space in AD patient suggests greater degree of brain atrophy. A lack of signal from CSF implies that the higher T1ρ values in AD patients are not due to free fluid. The error bars show mean WM T1ρ and GM T1ρ values in controls, MCI and AD patients (Fig. 2).


T1rho MRI and CSF biomarkers in diagnosis of Alzheimer's disease.

Haris M, Yadav SK, Rizwan A, Singh A, Cai K, Kaura D, Wang E, Davatzikos C, Trojanowski JQ, Melhem ER, Marincola FM, Borthakur A - Neuroimage Clin (2015)

T1rho (T1ρ) contrast from medial temporal lobe overlaid on anatomic fluid attenuated T1ρ weighted images of control (A), medial cognitive impairment (MCI, B), and Alzheimer's disease (AD, C) patients. A progressive increase in T1ρ contrast in medial temporal lobe (MTL) region was observed from control to MCI to AD. No T1ρ contrast from CSF was depicted.
© Copyright Policy - CC BY-NC-ND
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4375645&req=5

f0005: T1rho (T1ρ) contrast from medial temporal lobe overlaid on anatomic fluid attenuated T1ρ weighted images of control (A), medial cognitive impairment (MCI, B), and Alzheimer's disease (AD, C) patients. A progressive increase in T1ρ contrast in medial temporal lobe (MTL) region was observed from control to MCI to AD. No T1ρ contrast from CSF was depicted.
Mentions: Fig. 1 shows the overlaid T1ρ maps from MTL region (in color) on fluid-attenuated brain T1ρ weighted images of control, MCI, and AD patient. Pixels with higher T1ρ (red) are more prominent in MTL of AD patient. Increased sulcal space in AD patient suggests greater degree of brain atrophy. A lack of signal from CSF implies that the higher T1ρ values in AD patients are not due to free fluid. The error bars show mean WM T1ρ and GM T1ρ values in controls, MCI and AD patients (Fig. 2).

Bottom Line: On receiver operating characteristic analysis T1ρ showed higher sensitivity while CSF biomarkers showed greater specificity in delineating MCI and AD from controls.No significant correlation between T1ρ and CSF biomarkers, between T1ρ and age, and between CSF biomarkers and age was observed.Furthermore, disease progression form MCI to AD might be easily tracked using these two parameters in combination.

View Article: PubMed Central - PubMed

Affiliation: Research Branch, Sidra Medical and Research Center, Doha, Qatar ; Center for Magnetic Resonance and Optical Imaging, Department of Radiology, University of Pennsylvania, Philadelphia, PA, USA.

ABSTRACT
In the current study, we have evaluated the performance of magnetic resonance (MR) T1rho (T1ρ) imaging and CSF biomarkers (T-tau, P-tau and Aβ-42) in characterization of Alzheimer's disease (AD) patients from mild cognitive impairment (MCI) and control subjects. With informed consent, AD (n = 27), MCI (n = 17) and control (n = 17) subjects underwent a standardized clinical assessment and brain MRI on a 1.5-T clinical-scanner. T1ρ images were obtained at four different spin-lock pulse duration (10, 20, 30 and 40 ms). T1ρ maps were generated by pixel-wise fitting of signal intensity as a function of the spin-lock pulse duration. T1ρ values from gray matter (GM) and white matter (WM) of medial temporal lobe were calculated. The binary logistic regression using T1ρ and CSF biomarkers as variables was performed to classify each group. T1ρ was able to predict 77.3% controls and 40.0% MCI while CSF biomarkers predicted 81.8% controls and 46.7% MCI. T1ρ and CSF biomarkers in combination predicted 86.4% controls and 66.7% MCI. When comparing controls with AD, T1ρ predicted 68.2% controls and 73.9% AD, while CSF biomarkers predicted 77.3% controls and 78.3% for AD. Combination of T1ρ and CSF biomarkers improved the prediction rate to 81.8% for controls and 82.6% for AD. Similarly, on comparing MCI with AD, T1ρ predicted 35.3% MCI and 81.9% AD, whereas CSF biomarkers predicted 53.3% MCI and 83.0% AD. Collectively CSF biomarkers and T1ρ were able to predict 59.3% MCI and 84.6% AD. On receiver operating characteristic analysis T1ρ showed higher sensitivity while CSF biomarkers showed greater specificity in delineating MCI and AD from controls. No significant correlation between T1ρ and CSF biomarkers, between T1ρ and age, and between CSF biomarkers and age was observed. The combined use of T1ρ and CSF biomarkers have promise to improve the early and specific diagnosis of AD. Furthermore, disease progression form MCI to AD might be easily tracked using these two parameters in combination.

Show MeSH
Related in: MedlinePlus