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Multivariate pattern analysis reveals anatomical connectivity differences between the left and right mesial temporal lobe epilepsy.

Fang P, An J, Zeng LL, Shen H, Chen F, Wang W, Qiu S, Hu D - Neuroimage Clin (2015)

Bottom Line: The classification results reveal 93.0% accuracy for the left mTLE versus the right mTLE, 93.4% accuracy for the left mTLE versus controls and 90.0% accuracy for the right mTLE versus controls.Moreover, the orbitofrontal gyrus, cingulate cortex, hippocampus and parahippocampal gyrus, which exhibit high discriminative power in classification, may play critical roles in the pathophysiology of mTLE.The current study demonstrated that anatomical connectivity differences between the left mTLE and the right mTLE may have the potential to serve as a neuroimaging biomarker to guide personalized diagnosis of the left and right mTLE.

View Article: PubMed Central - PubMed

Affiliation: College of Mechatronics and Automation, National University of Defense Technology, Changsha, Hunan 410073, China.

ABSTRACT
Previous studies have demonstrated differences of clinical signs and functional brain network organizations between the left and right mesial temporal lobe epilepsy (mTLE), but the anatomical connectivity differences underlying functional variance between the left and right mTLE remain uncharacterized. We examined 43 (22 left, 21 right) mTLE patients with hippocampal sclerosis and 39 healthy controls using diffusion tensor imaging. After the whole-brain anatomical networks were constructed for each subject, multivariate pattern analysis was applied to classify the left mTLE from the right mTLE and extract the anatomical connectivity differences between the left and right mTLE patients. The classification results reveal 93.0% accuracy for the left mTLE versus the right mTLE, 93.4% accuracy for the left mTLE versus controls and 90.0% accuracy for the right mTLE versus controls. Compared with the right mTLE, the left mTLE exhibited a different connectivity pattern in the cortical-limbic network and cerebellum. The majority of the most discriminating anatomical connections were located within or across the cortical-limbic network and cerebellum, thereby indicating that these disease-related anatomical network alterations may give rise to a portion of the complex of emotional and memory deficit between the left and right mTLE. Moreover, the orbitofrontal gyrus, cingulate cortex, hippocampus and parahippocampal gyrus, which exhibit high discriminative power in classification, may play critical roles in the pathophysiology of mTLE. The current study demonstrated that anatomical connectivity differences between the left mTLE and the right mTLE may have the potential to serve as a neuroimaging biomarker to guide personalized diagnosis of the left and right mTLE.

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Related in: MedlinePlus

Region weights and distribution of the consensus anatomical connections. The results of classification for the left mTLE versus the right mTLE. The consensus connections are displayed on a surface rendering of the brain. The thickness of the connections adjusts according to their connectivity strength. Green and orange connections represent the decreased and increased connectivity in the left mTLE compared to the right mTLE. The connections are all decreased in the left and right mTLE compared to controls. However, the discriminating connections in the cerebellum and connections with occipital gyrus and ACC were more decreased in the left mTLE compared to those in the right mTLE. The diameter of the sphere represents the corresponding region weight of the ROI. The ROIs are color-coded according to brain areas (red = frontal cortex; orange = limbic cortex; yellow = parietal cortex; sky blue = cerebellar cortex; deep blue = temporal cortex; purple = occipital cortex). R = Right hemisphere, L = left hemisphere. med = medial; mid = middle; ope = opercular; tria = triangular; sup = superior; ORB = orbital frontal; SFG = superior frontal; ACG = anterior cingulum; SMA = supplementary motor area; INS = insula; AMYG = amygdala; PCG = post cingulum; PUT = putamen; HIP = hippocampus; PHG = parahippocampal; TPO = temporal pole; CUN = cuneus; MOG = middle occipital; PCUN = precuneus; LING = lingual; SPG = superior parietal; PoCG = postcentral; Cer = cerebelum.
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f0010: Region weights and distribution of the consensus anatomical connections. The results of classification for the left mTLE versus the right mTLE. The consensus connections are displayed on a surface rendering of the brain. The thickness of the connections adjusts according to their connectivity strength. Green and orange connections represent the decreased and increased connectivity in the left mTLE compared to the right mTLE. The connections are all decreased in the left and right mTLE compared to controls. However, the discriminating connections in the cerebellum and connections with occipital gyrus and ACC were more decreased in the left mTLE compared to those in the right mTLE. The diameter of the sphere represents the corresponding region weight of the ROI. The ROIs are color-coded according to brain areas (red = frontal cortex; orange = limbic cortex; yellow = parietal cortex; sky blue = cerebellar cortex; deep blue = temporal cortex; purple = occipital cortex). R = Right hemisphere, L = left hemisphere. med = medial; mid = middle; ope = opercular; tria = triangular; sup = superior; ORB = orbital frontal; SFG = superior frontal; ACG = anterior cingulum; SMA = supplementary motor area; INS = insula; AMYG = amygdala; PCG = post cingulum; PUT = putamen; HIP = hippocampus; PHG = parahippocampal; TPO = temporal pole; CUN = cuneus; MOG = middle occipital; PCUN = precuneus; LING = lingual; SPG = superior parietal; PoCG = postcentral; Cer = cerebelum.

Mentions: Because the training data differed for each LOOCV, the selected features varied slightly in each LOOCV. However, 43, 97 and 94 discriminating features, referred to as the consensus features (Dosenbach et al., 2010), were detected in every LOOCV for the left mTLE versus the right mTLE, the left mTLE versus controls and the right mTLE versus controls, respectively. These three sets of consensus features were considered the most discriminating features in the classification. The left mTLE exhibited variant connectivity patterns from the right mTLE in cortical-limbic network and cerebellum (Fig. 2, Table S1). Several ROIs, such as the orbitofrontal gyrus, insula, cingulate cortex, precuneus, hippocampus and parahippocampal gyrus, exhibited high region weights in the classification of the left mTLE versus the right mTLE. The orbitofrontal gyrus showed the greatest discriminative power in the classification and the anatomical connections between the orbitofrontal gyrus and the limbic area, the middle and superior prefrontal cortices were more decreased in the right mTLE than in the left mTLE. Additionally, connections from the hippocampus and parahippocampal gyrus to the cerebellum and occipital cortex may play important role in the neuropathology of mTLE. All the consensus connections were diminished in both the left and the right mTLE compared to the controls (for detail, please see SI, Tables S2 and S3). However, the discriminating connections in cerebellum and connections with occipital gyrus and ACC were more decreased in the left mTLE compared to those in the right mTLE. For visual assessment, the diameter of the sphere was scaled by the corresponding region weight of the ROI (Fig. 2).


Multivariate pattern analysis reveals anatomical connectivity differences between the left and right mesial temporal lobe epilepsy.

Fang P, An J, Zeng LL, Shen H, Chen F, Wang W, Qiu S, Hu D - Neuroimage Clin (2015)

Region weights and distribution of the consensus anatomical connections. The results of classification for the left mTLE versus the right mTLE. The consensus connections are displayed on a surface rendering of the brain. The thickness of the connections adjusts according to their connectivity strength. Green and orange connections represent the decreased and increased connectivity in the left mTLE compared to the right mTLE. The connections are all decreased in the left and right mTLE compared to controls. However, the discriminating connections in the cerebellum and connections with occipital gyrus and ACC were more decreased in the left mTLE compared to those in the right mTLE. The diameter of the sphere represents the corresponding region weight of the ROI. The ROIs are color-coded according to brain areas (red = frontal cortex; orange = limbic cortex; yellow = parietal cortex; sky blue = cerebellar cortex; deep blue = temporal cortex; purple = occipital cortex). R = Right hemisphere, L = left hemisphere. med = medial; mid = middle; ope = opercular; tria = triangular; sup = superior; ORB = orbital frontal; SFG = superior frontal; ACG = anterior cingulum; SMA = supplementary motor area; INS = insula; AMYG = amygdala; PCG = post cingulum; PUT = putamen; HIP = hippocampus; PHG = parahippocampal; TPO = temporal pole; CUN = cuneus; MOG = middle occipital; PCUN = precuneus; LING = lingual; SPG = superior parietal; PoCG = postcentral; Cer = cerebelum.
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f0010: Region weights and distribution of the consensus anatomical connections. The results of classification for the left mTLE versus the right mTLE. The consensus connections are displayed on a surface rendering of the brain. The thickness of the connections adjusts according to their connectivity strength. Green and orange connections represent the decreased and increased connectivity in the left mTLE compared to the right mTLE. The connections are all decreased in the left and right mTLE compared to controls. However, the discriminating connections in the cerebellum and connections with occipital gyrus and ACC were more decreased in the left mTLE compared to those in the right mTLE. The diameter of the sphere represents the corresponding region weight of the ROI. The ROIs are color-coded according to brain areas (red = frontal cortex; orange = limbic cortex; yellow = parietal cortex; sky blue = cerebellar cortex; deep blue = temporal cortex; purple = occipital cortex). R = Right hemisphere, L = left hemisphere. med = medial; mid = middle; ope = opercular; tria = triangular; sup = superior; ORB = orbital frontal; SFG = superior frontal; ACG = anterior cingulum; SMA = supplementary motor area; INS = insula; AMYG = amygdala; PCG = post cingulum; PUT = putamen; HIP = hippocampus; PHG = parahippocampal; TPO = temporal pole; CUN = cuneus; MOG = middle occipital; PCUN = precuneus; LING = lingual; SPG = superior parietal; PoCG = postcentral; Cer = cerebelum.
Mentions: Because the training data differed for each LOOCV, the selected features varied slightly in each LOOCV. However, 43, 97 and 94 discriminating features, referred to as the consensus features (Dosenbach et al., 2010), were detected in every LOOCV for the left mTLE versus the right mTLE, the left mTLE versus controls and the right mTLE versus controls, respectively. These three sets of consensus features were considered the most discriminating features in the classification. The left mTLE exhibited variant connectivity patterns from the right mTLE in cortical-limbic network and cerebellum (Fig. 2, Table S1). Several ROIs, such as the orbitofrontal gyrus, insula, cingulate cortex, precuneus, hippocampus and parahippocampal gyrus, exhibited high region weights in the classification of the left mTLE versus the right mTLE. The orbitofrontal gyrus showed the greatest discriminative power in the classification and the anatomical connections between the orbitofrontal gyrus and the limbic area, the middle and superior prefrontal cortices were more decreased in the right mTLE than in the left mTLE. Additionally, connections from the hippocampus and parahippocampal gyrus to the cerebellum and occipital cortex may play important role in the neuropathology of mTLE. All the consensus connections were diminished in both the left and the right mTLE compared to the controls (for detail, please see SI, Tables S2 and S3). However, the discriminating connections in cerebellum and connections with occipital gyrus and ACC were more decreased in the left mTLE compared to those in the right mTLE. For visual assessment, the diameter of the sphere was scaled by the corresponding region weight of the ROI (Fig. 2).

Bottom Line: The classification results reveal 93.0% accuracy for the left mTLE versus the right mTLE, 93.4% accuracy for the left mTLE versus controls and 90.0% accuracy for the right mTLE versus controls.Moreover, the orbitofrontal gyrus, cingulate cortex, hippocampus and parahippocampal gyrus, which exhibit high discriminative power in classification, may play critical roles in the pathophysiology of mTLE.The current study demonstrated that anatomical connectivity differences between the left mTLE and the right mTLE may have the potential to serve as a neuroimaging biomarker to guide personalized diagnosis of the left and right mTLE.

View Article: PubMed Central - PubMed

Affiliation: College of Mechatronics and Automation, National University of Defense Technology, Changsha, Hunan 410073, China.

ABSTRACT
Previous studies have demonstrated differences of clinical signs and functional brain network organizations between the left and right mesial temporal lobe epilepsy (mTLE), but the anatomical connectivity differences underlying functional variance between the left and right mTLE remain uncharacterized. We examined 43 (22 left, 21 right) mTLE patients with hippocampal sclerosis and 39 healthy controls using diffusion tensor imaging. After the whole-brain anatomical networks were constructed for each subject, multivariate pattern analysis was applied to classify the left mTLE from the right mTLE and extract the anatomical connectivity differences between the left and right mTLE patients. The classification results reveal 93.0% accuracy for the left mTLE versus the right mTLE, 93.4% accuracy for the left mTLE versus controls and 90.0% accuracy for the right mTLE versus controls. Compared with the right mTLE, the left mTLE exhibited a different connectivity pattern in the cortical-limbic network and cerebellum. The majority of the most discriminating anatomical connections were located within or across the cortical-limbic network and cerebellum, thereby indicating that these disease-related anatomical network alterations may give rise to a portion of the complex of emotional and memory deficit between the left and right mTLE. Moreover, the orbitofrontal gyrus, cingulate cortex, hippocampus and parahippocampal gyrus, which exhibit high discriminative power in classification, may play critical roles in the pathophysiology of mTLE. The current study demonstrated that anatomical connectivity differences between the left mTLE and the right mTLE may have the potential to serve as a neuroimaging biomarker to guide personalized diagnosis of the left and right mTLE.

Show MeSH
Related in: MedlinePlus