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Efficiency and safety of pulmonary rehabilitation in acute exacerbation of chronic obstructive pulmonary disease.

He M, Yu S, Wang L, Lv H, Qiu Z - Med. Sci. Monit. (2015)

Bottom Line: The 6MWD, resting SpO2, and exercise Borg dyspnea score were significantly improved in the PR group.Significant improvements were also found in the ADL-D and BODE index in the PR group.No adverse events were recorded during exercise.

View Article: PubMed Central - PubMed

Affiliation: Department of Respiratory Medicine, Tongji Hospital, Tongji University School of Medicine, Shanghai, China (mainland).

ABSTRACT

Background: Pulmonary rehabilitation (PR) is able to improve dyspnea, endurance capacity, and health-related quality of life in chronic obstructive pulmonary disease (COPD) patients, but it is rarely used in China. This study aimed to assess the effectiveness and safety of PR after exacerbation of COPD.

Material and methods: Patients admitted to hospital due to an exacerbation of COPD were randomized to receive either PR or routine care (control group). The PR program was performed from the second day of admission until discharge. The pre-post changes in 6-minute walk distance (6MWD), self-reported quality of life (QOL) assessed by CAT score and CRQ-SAS score, and activity of daily life assessed by ADL-D score were determined. The perceived end-effort dyspnea (Borg scale) was measured throughout the study.

Results: A total of 101 patients were enrolled, of whom 7 withdrew after randomization, and 94 completed this study. There were 66 patients in the PR group and 28 in the control group. The 6MWD, resting SpO2, and exercise Borg dyspnea score were significantly improved in the PR group. In addition, the PR group had greater improvement in the total CRQ-SAS score and had a lower CAT score. Significant improvements were also found in the ADL-D and BODE index in the PR group. No adverse events were recorded during exercise.

Conclusions: Our study provides evidence that it is safe and feasible to apply an early PR in patients with acute exacerbation of COPD.

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Related in: MedlinePlus

Effects of PR on QOL, assessed by CAT score (A) and CRQ-SAS score (B). Open circle: PR group before PR, solid circle: PR group after PR, open triangle: control group before PR, solid triangle: control group after routine care.
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f2-medscimonit-21-806: Effects of PR on QOL, assessed by CAT score (A) and CRQ-SAS score (B). Open circle: PR group before PR, solid circle: PR group after PR, open triangle: control group before PR, solid triangle: control group after routine care.

Mentions: There was a significant improvement in CAT score (the lower the score, the better the QOL was) in both the PR group and the control group. There was a significant improvement in CRQ-SAS score in the PR group from baseline to post-PR (P<0.001) and a slight decline in the control group (Figure 2). The ADL-D score was improved as indicated by an increase in total score from 40.4±2.19 to 60.7±2.31 in the PR group, and a significant increase was observed after PR. ADL-D score was also improved as indicated by an increase in total score form 53.3±2.19 to 58.07±2.43 in the control group, but there was no significant difference (Figure 3).


Efficiency and safety of pulmonary rehabilitation in acute exacerbation of chronic obstructive pulmonary disease.

He M, Yu S, Wang L, Lv H, Qiu Z - Med. Sci. Monit. (2015)

Effects of PR on QOL, assessed by CAT score (A) and CRQ-SAS score (B). Open circle: PR group before PR, solid circle: PR group after PR, open triangle: control group before PR, solid triangle: control group after routine care.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4374486&req=5

f2-medscimonit-21-806: Effects of PR on QOL, assessed by CAT score (A) and CRQ-SAS score (B). Open circle: PR group before PR, solid circle: PR group after PR, open triangle: control group before PR, solid triangle: control group after routine care.
Mentions: There was a significant improvement in CAT score (the lower the score, the better the QOL was) in both the PR group and the control group. There was a significant improvement in CRQ-SAS score in the PR group from baseline to post-PR (P<0.001) and a slight decline in the control group (Figure 2). The ADL-D score was improved as indicated by an increase in total score from 40.4±2.19 to 60.7±2.31 in the PR group, and a significant increase was observed after PR. ADL-D score was also improved as indicated by an increase in total score form 53.3±2.19 to 58.07±2.43 in the control group, but there was no significant difference (Figure 3).

Bottom Line: The 6MWD, resting SpO2, and exercise Borg dyspnea score were significantly improved in the PR group.Significant improvements were also found in the ADL-D and BODE index in the PR group.No adverse events were recorded during exercise.

View Article: PubMed Central - PubMed

Affiliation: Department of Respiratory Medicine, Tongji Hospital, Tongji University School of Medicine, Shanghai, China (mainland).

ABSTRACT

Background: Pulmonary rehabilitation (PR) is able to improve dyspnea, endurance capacity, and health-related quality of life in chronic obstructive pulmonary disease (COPD) patients, but it is rarely used in China. This study aimed to assess the effectiveness and safety of PR after exacerbation of COPD.

Material and methods: Patients admitted to hospital due to an exacerbation of COPD were randomized to receive either PR or routine care (control group). The PR program was performed from the second day of admission until discharge. The pre-post changes in 6-minute walk distance (6MWD), self-reported quality of life (QOL) assessed by CAT score and CRQ-SAS score, and activity of daily life assessed by ADL-D score were determined. The perceived end-effort dyspnea (Borg scale) was measured throughout the study.

Results: A total of 101 patients were enrolled, of whom 7 withdrew after randomization, and 94 completed this study. There were 66 patients in the PR group and 28 in the control group. The 6MWD, resting SpO2, and exercise Borg dyspnea score were significantly improved in the PR group. In addition, the PR group had greater improvement in the total CRQ-SAS score and had a lower CAT score. Significant improvements were also found in the ADL-D and BODE index in the PR group. No adverse events were recorded during exercise.

Conclusions: Our study provides evidence that it is safe and feasible to apply an early PR in patients with acute exacerbation of COPD.

Show MeSH
Related in: MedlinePlus