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Efficiency and safety of pulmonary rehabilitation in acute exacerbation of chronic obstructive pulmonary disease.

He M, Yu S, Wang L, Lv H, Qiu Z - Med. Sci. Monit. (2015)

Bottom Line: The 6MWD, resting SpO2, and exercise Borg dyspnea score were significantly improved in the PR group.Significant improvements were also found in the ADL-D and BODE index in the PR group.No adverse events were recorded during exercise.

View Article: PubMed Central - PubMed

Affiliation: Department of Respiratory Medicine, Tongji Hospital, Tongji University School of Medicine, Shanghai, China (mainland).

ABSTRACT

Background: Pulmonary rehabilitation (PR) is able to improve dyspnea, endurance capacity, and health-related quality of life in chronic obstructive pulmonary disease (COPD) patients, but it is rarely used in China. This study aimed to assess the effectiveness and safety of PR after exacerbation of COPD.

Material and methods: Patients admitted to hospital due to an exacerbation of COPD were randomized to receive either PR or routine care (control group). The PR program was performed from the second day of admission until discharge. The pre-post changes in 6-minute walk distance (6MWD), self-reported quality of life (QOL) assessed by CAT score and CRQ-SAS score, and activity of daily life assessed by ADL-D score were determined. The perceived end-effort dyspnea (Borg scale) was measured throughout the study.

Results: A total of 101 patients were enrolled, of whom 7 withdrew after randomization, and 94 completed this study. There were 66 patients in the PR group and 28 in the control group. The 6MWD, resting SpO2, and exercise Borg dyspnea score were significantly improved in the PR group. In addition, the PR group had greater improvement in the total CRQ-SAS score and had a lower CAT score. Significant improvements were also found in the ADL-D and BODE index in the PR group. No adverse events were recorded during exercise.

Conclusions: Our study provides evidence that it is safe and feasible to apply an early PR in patients with acute exacerbation of COPD.

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Related in: MedlinePlus

Effects of PR on 6MWD. Open circle: PR group before PR, solid circle: PR group after PR, open triangle: control group before PR, solid triangle: control group after usual care.
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f1-medscimonit-21-806: Effects of PR on 6MWD. Open circle: PR group before PR, solid circle: PR group after PR, open triangle: control group before PR, solid triangle: control group after usual care.

Mentions: No adverse events were recorded during exercise training. The 6MWD was increased by 49.0m in PR group as compared to that at baseline (242.0±15.03 m vs. 291.0±14.61m, P<0.001). In contrast, the 6MWD was increased by 9.9 m (263.9±20.75 m vs. 273.7±20.03 m) in the control group as compared to that at baseline, showing no significant difference (P=0.620, Figure 1). There was a significant improvement in resting SpO2 at rest in the PR group as compared to baseline. There was a significant improvement in the dyspnea at rest as measured by Borg dyspnea score in both the PR and control groups as compared to that at baseline. However, a significant improvement was observed in dyspnea at exercises (P=0.008) only in the PR group, but not in the control group (P=0.108). These findings suggested that there was a significant improvement in the exercise capacity after PR (Table 2).


Efficiency and safety of pulmonary rehabilitation in acute exacerbation of chronic obstructive pulmonary disease.

He M, Yu S, Wang L, Lv H, Qiu Z - Med. Sci. Monit. (2015)

Effects of PR on 6MWD. Open circle: PR group before PR, solid circle: PR group after PR, open triangle: control group before PR, solid triangle: control group after usual care.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4374486&req=5

f1-medscimonit-21-806: Effects of PR on 6MWD. Open circle: PR group before PR, solid circle: PR group after PR, open triangle: control group before PR, solid triangle: control group after usual care.
Mentions: No adverse events were recorded during exercise training. The 6MWD was increased by 49.0m in PR group as compared to that at baseline (242.0±15.03 m vs. 291.0±14.61m, P<0.001). In contrast, the 6MWD was increased by 9.9 m (263.9±20.75 m vs. 273.7±20.03 m) in the control group as compared to that at baseline, showing no significant difference (P=0.620, Figure 1). There was a significant improvement in resting SpO2 at rest in the PR group as compared to baseline. There was a significant improvement in the dyspnea at rest as measured by Borg dyspnea score in both the PR and control groups as compared to that at baseline. However, a significant improvement was observed in dyspnea at exercises (P=0.008) only in the PR group, but not in the control group (P=0.108). These findings suggested that there was a significant improvement in the exercise capacity after PR (Table 2).

Bottom Line: The 6MWD, resting SpO2, and exercise Borg dyspnea score were significantly improved in the PR group.Significant improvements were also found in the ADL-D and BODE index in the PR group.No adverse events were recorded during exercise.

View Article: PubMed Central - PubMed

Affiliation: Department of Respiratory Medicine, Tongji Hospital, Tongji University School of Medicine, Shanghai, China (mainland).

ABSTRACT

Background: Pulmonary rehabilitation (PR) is able to improve dyspnea, endurance capacity, and health-related quality of life in chronic obstructive pulmonary disease (COPD) patients, but it is rarely used in China. This study aimed to assess the effectiveness and safety of PR after exacerbation of COPD.

Material and methods: Patients admitted to hospital due to an exacerbation of COPD were randomized to receive either PR or routine care (control group). The PR program was performed from the second day of admission until discharge. The pre-post changes in 6-minute walk distance (6MWD), self-reported quality of life (QOL) assessed by CAT score and CRQ-SAS score, and activity of daily life assessed by ADL-D score were determined. The perceived end-effort dyspnea (Borg scale) was measured throughout the study.

Results: A total of 101 patients were enrolled, of whom 7 withdrew after randomization, and 94 completed this study. There were 66 patients in the PR group and 28 in the control group. The 6MWD, resting SpO2, and exercise Borg dyspnea score were significantly improved in the PR group. In addition, the PR group had greater improvement in the total CRQ-SAS score and had a lower CAT score. Significant improvements were also found in the ADL-D and BODE index in the PR group. No adverse events were recorded during exercise.

Conclusions: Our study provides evidence that it is safe and feasible to apply an early PR in patients with acute exacerbation of COPD.

Show MeSH
Related in: MedlinePlus