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Abnormal cardiovascular sympathetic and parasympathetic responses to physical and emotional stimuli in depersonalization disorder.

Owens AP, David AS, Low DA, Mathias CJ, Sierra-Siegert M - Front Neurosci (2015)

Bottom Line: Depersonalization disorder (DPD) is characterized by a subjective sense of unreality, disembodiment, emotional numbing and reduced psychogenic (sudomotor) sympathoexcitation.In study II, DPD high frequency HRV (HF-HRV)-indicating parasympathetic vagal activity-was reduced (p = 0.029).These studies suggest the cardiovascular autonomic dysregulation in DPD is likely to be centrally-mediated.

View Article: PubMed Central - PubMed

Affiliation: Autonomic and Neurovascular Medicine Unit, Institute of Neurology, Imperial College London London, UK ; Autonomic Unit, Institute of Neurology, University College London London, UK.

ABSTRACT

Background: Depersonalization disorder (DPD) is characterized by a subjective sense of unreality, disembodiment, emotional numbing and reduced psychogenic (sudomotor) sympathoexcitation.

Aims: Three related experiments utilized escalating physical and emotional challenges in 14 DPD participants and 16 controls aimed to elucidate (i) whether the cardiovascular sympathetic (SNS) and parasympathetic (PNS) nervous systems are implicated in DPD pathophysiology and (ii) if possible, to determine whether the blunted sympathoexcitation in DPD is peripherally or centrally mediated.

Method: Participants completed the Beck Anxiety Inventory (BAI), Dissociative Experience Scale (DES), and Cambridge Depersonalization Scale (CDS). Study I recorded heart rate (HR) and blood pressure (BP) during 5 min supine baseline, 3 min sustained handgrip (HG), 3 min cold pressor (CP) and 5 min 60° head-up tilt (HUT). In study II, HR, BP, and heart rate variability (HRV) were recorded during 5 min simultaneous 60° HUT and continuous presentation of unpleasant images (5 s per image). Study III examined HR and BP orienting responses (ORs) to simultaneous 60° HUT and pseudorandom presentation of unpleasant, neutral and pleasant images (5 s per image 3 min 25 s). OR data was grouped by image valence post hoc.

Results: DPD BAI (p = 0.0004), DES (p = 0.0002), and CDS (p ≤ 0.0001) scores were higher than controls. The DPD group produced diminished diastolic BP (DBP) (p = 0.045) increases to HG. Other indices were comparable between groups. DPD participants produced diminished systolic BP (SBP) (p = 0.003) and DBP (p = 0.002) increases, but greater (p = 0.004) HR increases to CP. In study II, DPD high frequency HRV (HF-HRV)-indicating parasympathetic vagal activity-was reduced (p = 0.029). In study III, DPD DBP was higher throughout the 5 s duration of HUT/pseudorandom unpleasant image presentation (1 s, p = 0.002, 2 s p = 0.033, 3 s p = 0.001, 4 s p = 0.009, 5 s p = 0.029).

Conclusions: Study I's BP pressor data supports previous findings of suppressed sympathoexcitation in DPD. The greater HR increases to CP, decreased HF-HRV in study II, and increased DBP during unpleasant ORs in study III implicates the SNS and PNS in DPD pathophysiology. These studies suggest the cardiovascular autonomic dysregulation in DPD is likely to be centrally-mediated.

No MeSH data available.


Related in: MedlinePlus

HF-HRV data during supine baseline (BL), head up tilt (HUT), and HUT viewing of unpleasant images. DPD, Depersonalization Disorder group; HC, healthy control group; uIAPS, unpleasant images from the International Affective Picture System. *P ≤ 0.05.
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Figure 1: HF-HRV data during supine baseline (BL), head up tilt (HUT), and HUT viewing of unpleasant images. DPD, Depersonalization Disorder group; HC, healthy control group; uIAPS, unpleasant images from the International Affective Picture System. *P ≤ 0.05.

Mentions: During 5 min supine baseline and HUT baseline, both groups produced similar HRV and BP profiles. LF changes during 5 min simultaneous HUT and unpleasant images were not significant between groups, however, there was a significantly greater reduction (p = 0.029) in HF-HRV in the DPD group in comparison to controls (see Figure 1). BP responses to HUT did not differ significantly between groups.


Abnormal cardiovascular sympathetic and parasympathetic responses to physical and emotional stimuli in depersonalization disorder.

Owens AP, David AS, Low DA, Mathias CJ, Sierra-Siegert M - Front Neurosci (2015)

HF-HRV data during supine baseline (BL), head up tilt (HUT), and HUT viewing of unpleasant images. DPD, Depersonalization Disorder group; HC, healthy control group; uIAPS, unpleasant images from the International Affective Picture System. *P ≤ 0.05.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4374468&req=5

Figure 1: HF-HRV data during supine baseline (BL), head up tilt (HUT), and HUT viewing of unpleasant images. DPD, Depersonalization Disorder group; HC, healthy control group; uIAPS, unpleasant images from the International Affective Picture System. *P ≤ 0.05.
Mentions: During 5 min supine baseline and HUT baseline, both groups produced similar HRV and BP profiles. LF changes during 5 min simultaneous HUT and unpleasant images were not significant between groups, however, there was a significantly greater reduction (p = 0.029) in HF-HRV in the DPD group in comparison to controls (see Figure 1). BP responses to HUT did not differ significantly between groups.

Bottom Line: Depersonalization disorder (DPD) is characterized by a subjective sense of unreality, disembodiment, emotional numbing and reduced psychogenic (sudomotor) sympathoexcitation.In study II, DPD high frequency HRV (HF-HRV)-indicating parasympathetic vagal activity-was reduced (p = 0.029).These studies suggest the cardiovascular autonomic dysregulation in DPD is likely to be centrally-mediated.

View Article: PubMed Central - PubMed

Affiliation: Autonomic and Neurovascular Medicine Unit, Institute of Neurology, Imperial College London London, UK ; Autonomic Unit, Institute of Neurology, University College London London, UK.

ABSTRACT

Background: Depersonalization disorder (DPD) is characterized by a subjective sense of unreality, disembodiment, emotional numbing and reduced psychogenic (sudomotor) sympathoexcitation.

Aims: Three related experiments utilized escalating physical and emotional challenges in 14 DPD participants and 16 controls aimed to elucidate (i) whether the cardiovascular sympathetic (SNS) and parasympathetic (PNS) nervous systems are implicated in DPD pathophysiology and (ii) if possible, to determine whether the blunted sympathoexcitation in DPD is peripherally or centrally mediated.

Method: Participants completed the Beck Anxiety Inventory (BAI), Dissociative Experience Scale (DES), and Cambridge Depersonalization Scale (CDS). Study I recorded heart rate (HR) and blood pressure (BP) during 5 min supine baseline, 3 min sustained handgrip (HG), 3 min cold pressor (CP) and 5 min 60° head-up tilt (HUT). In study II, HR, BP, and heart rate variability (HRV) were recorded during 5 min simultaneous 60° HUT and continuous presentation of unpleasant images (5 s per image). Study III examined HR and BP orienting responses (ORs) to simultaneous 60° HUT and pseudorandom presentation of unpleasant, neutral and pleasant images (5 s per image 3 min 25 s). OR data was grouped by image valence post hoc.

Results: DPD BAI (p = 0.0004), DES (p = 0.0002), and CDS (p ≤ 0.0001) scores were higher than controls. The DPD group produced diminished diastolic BP (DBP) (p = 0.045) increases to HG. Other indices were comparable between groups. DPD participants produced diminished systolic BP (SBP) (p = 0.003) and DBP (p = 0.002) increases, but greater (p = 0.004) HR increases to CP. In study II, DPD high frequency HRV (HF-HRV)-indicating parasympathetic vagal activity-was reduced (p = 0.029). In study III, DPD DBP was higher throughout the 5 s duration of HUT/pseudorandom unpleasant image presentation (1 s, p = 0.002, 2 s p = 0.033, 3 s p = 0.001, 4 s p = 0.009, 5 s p = 0.029).

Conclusions: Study I's BP pressor data supports previous findings of suppressed sympathoexcitation in DPD. The greater HR increases to CP, decreased HF-HRV in study II, and increased DBP during unpleasant ORs in study III implicates the SNS and PNS in DPD pathophysiology. These studies suggest the cardiovascular autonomic dysregulation in DPD is likely to be centrally-mediated.

No MeSH data available.


Related in: MedlinePlus