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Shaping pseudoneglect with transcranial cerebellar direct current stimulation and music listening.

Picazio S, Granata C, Caltagirone C, Petrosini L, Oliveri M - Front Hum Neurosci (2015)

Bottom Line: We applied this new state-dependency approach to investigate the cerebellar role in musical and spatial information processing, given that a link between musical perception and visuo-spatial abilities and a clear cerebellar involvement in music perception and visuo-spatial tasks have been reported.Conversely, the anodal or sham pre-conditioning stimulations combined with either music and white noise conditioning listening did not modulate spatial attention.They propose that tcDCS in combination with music listening could act as a rehabilitative tool to improve cognitive functions in the presence of neglect or other spatial disorders.

View Article: PubMed Central - PubMed

Affiliation: Clinical and Behavioral Neurology Laboratory, Non-Invasive Brain Stimulation Unit, IRCCS "Santa Lucia" Foundation Rome, Italy ; Department of Psychology, "Sapienza" University of Rome Rome, Italy.

ABSTRACT
Non-invasive brain stimulation modulates cortical excitability depending on the initial activation state of the structure being stimulated. Combination of cognitive with neurophysiological stimulations has been successfully employed to modulate responses of specific brain regions. The present research combined a neurophysiological pre-conditioning with a cognitive conditioning stimulation to modulate behavior. We applied this new state-dependency approach to investigate the cerebellar role in musical and spatial information processing, given that a link between musical perception and visuo-spatial abilities and a clear cerebellar involvement in music perception and visuo-spatial tasks have been reported. Cathodal, anodal or sham transcranial cerebellar Direct Current Stimulation (tcDCS) pre-conditioning was applied on the left cerebellar hemisphere followed by conditioning stimulation through music or white noise listening in a sample of healthy subjects performing a Line Bisection Task (LBT). The combination of the cathodal stimulation with music listening resulted in a marked attentional shift toward the right hemispace, compensating thus the natural leftward bias of the baseline condition (pseudoneglect). Conversely, the anodal or sham pre-conditioning stimulations combined with either music and white noise conditioning listening did not modulate spatial attention. The efficacy of the combined stimulation (cathodal pre-conditioning and music conditioning) and the absence of any effect of the single stimulations provide a strong support to the state-dependency theory. They propose that tcDCS in combination with music listening could act as a rehabilitative tool to improve cognitive functions in the presence of neglect or other spatial disorders.

No MeSH data available.


Related in: MedlinePlus

(A) Mean pre values. A slight spatial leftward (negative values) bias was observed. (B) LBT performance. Following Cathodal + M stimulation a significant shift toward the right space (positive values) was observed. *p < 0.05; **p < 0.01. Error bars indicated standard error of mean.
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Figure 3: (A) Mean pre values. A slight spatial leftward (negative values) bias was observed. (B) LBT performance. Following Cathodal + M stimulation a significant shift toward the right space (positive values) was observed. *p < 0.05; **p < 0.01. Error bars indicated standard error of mean.

Mentions: One-way repeated measure ANOVA on the scores obtained before the six combined stimulations revealed no significant difference (F5,60 = 1.17; p = 0.331). On average, the subjects judged the left segment of the line as longer than the right one, evidencing a slight spatial leftwards bias (pseudoneglect). By comparing the mean score ( : −0.047 ± 0.08) in all pre-stimulation conditions (baseline) with the theoretically unbiased score of 0, by means of a paired T-Test, a significant difference was found (p < 0.006) (Figure 3A).


Shaping pseudoneglect with transcranial cerebellar direct current stimulation and music listening.

Picazio S, Granata C, Caltagirone C, Petrosini L, Oliveri M - Front Hum Neurosci (2015)

(A) Mean pre values. A slight spatial leftward (negative values) bias was observed. (B) LBT performance. Following Cathodal + M stimulation a significant shift toward the right space (positive values) was observed. *p < 0.05; **p < 0.01. Error bars indicated standard error of mean.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4374462&req=5

Figure 3: (A) Mean pre values. A slight spatial leftward (negative values) bias was observed. (B) LBT performance. Following Cathodal + M stimulation a significant shift toward the right space (positive values) was observed. *p < 0.05; **p < 0.01. Error bars indicated standard error of mean.
Mentions: One-way repeated measure ANOVA on the scores obtained before the six combined stimulations revealed no significant difference (F5,60 = 1.17; p = 0.331). On average, the subjects judged the left segment of the line as longer than the right one, evidencing a slight spatial leftwards bias (pseudoneglect). By comparing the mean score ( : −0.047 ± 0.08) in all pre-stimulation conditions (baseline) with the theoretically unbiased score of 0, by means of a paired T-Test, a significant difference was found (p < 0.006) (Figure 3A).

Bottom Line: We applied this new state-dependency approach to investigate the cerebellar role in musical and spatial information processing, given that a link between musical perception and visuo-spatial abilities and a clear cerebellar involvement in music perception and visuo-spatial tasks have been reported.Conversely, the anodal or sham pre-conditioning stimulations combined with either music and white noise conditioning listening did not modulate spatial attention.They propose that tcDCS in combination with music listening could act as a rehabilitative tool to improve cognitive functions in the presence of neglect or other spatial disorders.

View Article: PubMed Central - PubMed

Affiliation: Clinical and Behavioral Neurology Laboratory, Non-Invasive Brain Stimulation Unit, IRCCS "Santa Lucia" Foundation Rome, Italy ; Department of Psychology, "Sapienza" University of Rome Rome, Italy.

ABSTRACT
Non-invasive brain stimulation modulates cortical excitability depending on the initial activation state of the structure being stimulated. Combination of cognitive with neurophysiological stimulations has been successfully employed to modulate responses of specific brain regions. The present research combined a neurophysiological pre-conditioning with a cognitive conditioning stimulation to modulate behavior. We applied this new state-dependency approach to investigate the cerebellar role in musical and spatial information processing, given that a link between musical perception and visuo-spatial abilities and a clear cerebellar involvement in music perception and visuo-spatial tasks have been reported. Cathodal, anodal or sham transcranial cerebellar Direct Current Stimulation (tcDCS) pre-conditioning was applied on the left cerebellar hemisphere followed by conditioning stimulation through music or white noise listening in a sample of healthy subjects performing a Line Bisection Task (LBT). The combination of the cathodal stimulation with music listening resulted in a marked attentional shift toward the right hemispace, compensating thus the natural leftward bias of the baseline condition (pseudoneglect). Conversely, the anodal or sham pre-conditioning stimulations combined with either music and white noise conditioning listening did not modulate spatial attention. The efficacy of the combined stimulation (cathodal pre-conditioning and music conditioning) and the absence of any effect of the single stimulations provide a strong support to the state-dependency theory. They propose that tcDCS in combination with music listening could act as a rehabilitative tool to improve cognitive functions in the presence of neglect or other spatial disorders.

No MeSH data available.


Related in: MedlinePlus