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Changes of lipid profiles after radical gastrectomy in patients with gastric cancer.

Lee JW, Kim EY, Yoo HM, Park CH, Song KY - Lipids Health Dis (2015)

Bottom Line: The TC level had decreased 6 months after surgery, and remained unchanged thereafter.The LDL level also had decreased 6 months after surgery, but had increased again after 12 months after surgery.Both the male gender and total gastrectomy were associated with probability of normalization of LDL after surgery.

View Article: PubMed Central - PubMed

Affiliation: Department of Surgery, Seoul St. Mary's Hospital, The Catholic University of Korea, College of Medicine, 222 Banpo-daero, Seocho-gu, Seoul, 137-701, Korea. sdf911@naver.com.

ABSTRACT

Background: We investigated the changes of lipid profiles after radical gastrectomy.

Methods: We analyzed the lipid-profile changes after radical gastrectomy in 144 patients with gastric cancer. Their lipid profiles, including total cholesterol (TC), triglyceride (TG), LDL-cholesterol (LDL), and HDL-cholesterol (HDL), were evaluated preoperatively as well as 6 and 12 months postoperatively. We compared the changes of lipid profile according to the reconstruction type and resection extent.

Results: The TC level had decreased 6 months after surgery, and remained unchanged thereafter. The LDL level also had decreased 6 months after surgery, but had increased again after 12 months after surgery. The HDL level had increased 12 months after surgery, whereas the TG level was unchanged. In a comparison of the lipid levels according to the reconstruction type or resection extent, the HDL level significantly differed by reconstruction type 12 months after surgery: it was markedly higher in the total gastrectomy than in the subtotal gastrectomy group both 6 months and 12 months after surgery. Both the male gender and total gastrectomy were associated with probability of normalization of LDL after surgery.

Conclusions: The lipid profiles including the TC, LDL and HDL levels were changed after radical gastrectomy; therefore, after this procedure, the lipid profiles of patients with hyperlipidemia should be evaluated.

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Correlations between baseline characteristics and LDL-cholesterol. The data are presented as Spearman’s rank correlation coefficients (p values).
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Fig4: Correlations between baseline characteristics and LDL-cholesterol. The data are presented as Spearman’s rank correlation coefficients (p values).

Mentions: Finally, we examined the correlations between the patients’ LDL levels and their baseline characteristics by Spearman correlation analysis. Changes of LDL were associated with weight loss in all patients 6 months after surgery (r = 0.17, P = 0.0433), and this association was significant in the patients who had undergone subtotal gastrectomy (r = 0.23, P = 0.0196). In the patients who had undergone total gastrectomy, the change of LDL from 6 to 12 months postoperatively also was related to weight loss (r = 0.40, P = 0.0117). The change of LDL from 6 to 12 months postoperatively in the patients who had undergone B-I reconstruction, meanwhile, was associated with both BMI (r = 0.40, P = 0.0124) and FBS (r = 0.47, P = 0.0317). The LDL change from 6 to 12 months postoperatively in those who had undergone RY reconstruction was associated with weight loss(r = 0.35, P = 0.02) (Figure 4).Figure 4


Changes of lipid profiles after radical gastrectomy in patients with gastric cancer.

Lee JW, Kim EY, Yoo HM, Park CH, Song KY - Lipids Health Dis (2015)

Correlations between baseline characteristics and LDL-cholesterol. The data are presented as Spearman’s rank correlation coefficients (p values).
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4374421&req=5

Fig4: Correlations between baseline characteristics and LDL-cholesterol. The data are presented as Spearman’s rank correlation coefficients (p values).
Mentions: Finally, we examined the correlations between the patients’ LDL levels and their baseline characteristics by Spearman correlation analysis. Changes of LDL were associated with weight loss in all patients 6 months after surgery (r = 0.17, P = 0.0433), and this association was significant in the patients who had undergone subtotal gastrectomy (r = 0.23, P = 0.0196). In the patients who had undergone total gastrectomy, the change of LDL from 6 to 12 months postoperatively also was related to weight loss (r = 0.40, P = 0.0117). The change of LDL from 6 to 12 months postoperatively in the patients who had undergone B-I reconstruction, meanwhile, was associated with both BMI (r = 0.40, P = 0.0124) and FBS (r = 0.47, P = 0.0317). The LDL change from 6 to 12 months postoperatively in those who had undergone RY reconstruction was associated with weight loss(r = 0.35, P = 0.02) (Figure 4).Figure 4

Bottom Line: The TC level had decreased 6 months after surgery, and remained unchanged thereafter.The LDL level also had decreased 6 months after surgery, but had increased again after 12 months after surgery.Both the male gender and total gastrectomy were associated with probability of normalization of LDL after surgery.

View Article: PubMed Central - PubMed

Affiliation: Department of Surgery, Seoul St. Mary's Hospital, The Catholic University of Korea, College of Medicine, 222 Banpo-daero, Seocho-gu, Seoul, 137-701, Korea. sdf911@naver.com.

ABSTRACT

Background: We investigated the changes of lipid profiles after radical gastrectomy.

Methods: We analyzed the lipid-profile changes after radical gastrectomy in 144 patients with gastric cancer. Their lipid profiles, including total cholesterol (TC), triglyceride (TG), LDL-cholesterol (LDL), and HDL-cholesterol (HDL), were evaluated preoperatively as well as 6 and 12 months postoperatively. We compared the changes of lipid profile according to the reconstruction type and resection extent.

Results: The TC level had decreased 6 months after surgery, and remained unchanged thereafter. The LDL level also had decreased 6 months after surgery, but had increased again after 12 months after surgery. The HDL level had increased 12 months after surgery, whereas the TG level was unchanged. In a comparison of the lipid levels according to the reconstruction type or resection extent, the HDL level significantly differed by reconstruction type 12 months after surgery: it was markedly higher in the total gastrectomy than in the subtotal gastrectomy group both 6 months and 12 months after surgery. Both the male gender and total gastrectomy were associated with probability of normalization of LDL after surgery.

Conclusions: The lipid profiles including the TC, LDL and HDL levels were changed after radical gastrectomy; therefore, after this procedure, the lipid profiles of patients with hyperlipidemia should be evaluated.

Show MeSH
Related in: MedlinePlus