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Changes of lipid profiles after radical gastrectomy in patients with gastric cancer.

Lee JW, Kim EY, Yoo HM, Park CH, Song KY - Lipids Health Dis (2015)

Bottom Line: The TC level had decreased 6 months after surgery, and remained unchanged thereafter.The LDL level also had decreased 6 months after surgery, but had increased again after 12 months after surgery.Both the male gender and total gastrectomy were associated with probability of normalization of LDL after surgery.

View Article: PubMed Central - PubMed

Affiliation: Department of Surgery, Seoul St. Mary's Hospital, The Catholic University of Korea, College of Medicine, 222 Banpo-daero, Seocho-gu, Seoul, 137-701, Korea. sdf911@naver.com.

ABSTRACT

Background: We investigated the changes of lipid profiles after radical gastrectomy.

Methods: We analyzed the lipid-profile changes after radical gastrectomy in 144 patients with gastric cancer. Their lipid profiles, including total cholesterol (TC), triglyceride (TG), LDL-cholesterol (LDL), and HDL-cholesterol (HDL), were evaluated preoperatively as well as 6 and 12 months postoperatively. We compared the changes of lipid profile according to the reconstruction type and resection extent.

Results: The TC level had decreased 6 months after surgery, and remained unchanged thereafter. The LDL level also had decreased 6 months after surgery, but had increased again after 12 months after surgery. The HDL level had increased 12 months after surgery, whereas the TG level was unchanged. In a comparison of the lipid levels according to the reconstruction type or resection extent, the HDL level significantly differed by reconstruction type 12 months after surgery: it was markedly higher in the total gastrectomy than in the subtotal gastrectomy group both 6 months and 12 months after surgery. Both the male gender and total gastrectomy were associated with probability of normalization of LDL after surgery.

Conclusions: The lipid profiles including the TC, LDL and HDL levels were changed after radical gastrectomy; therefore, after this procedure, the lipid profiles of patients with hyperlipidemia should be evaluated.

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Related in: MedlinePlus

Subgroup analysis of metabolic parameters 6 and 12 months after gastrectomy by reconstruction type (*B-I vs. RY, †B-I vs. B-II, and ‡B-II vs. RY (P < 0.05)).
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Fig2: Subgroup analysis of metabolic parameters 6 and 12 months after gastrectomy by reconstruction type (*B-I vs. RY, †B-I vs. B-II, and ‡B-II vs. RY (P < 0.05)).

Mentions: We next compared the lipid-profile changes according to the reconstruction type. No differences in TC, TG or LDL level were apparent for the reconstruction types either 6 or 12 months after surgery. The level of HDL, by contrast, was significantly lower in patients who had undergone Roux-en-Y (RY) reconstruction than in those who had undergone Billroth I or II 12 months after surgery (P = 0.0098) (Figure 2).Figure 2


Changes of lipid profiles after radical gastrectomy in patients with gastric cancer.

Lee JW, Kim EY, Yoo HM, Park CH, Song KY - Lipids Health Dis (2015)

Subgroup analysis of metabolic parameters 6 and 12 months after gastrectomy by reconstruction type (*B-I vs. RY, †B-I vs. B-II, and ‡B-II vs. RY (P < 0.05)).
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4374421&req=5

Fig2: Subgroup analysis of metabolic parameters 6 and 12 months after gastrectomy by reconstruction type (*B-I vs. RY, †B-I vs. B-II, and ‡B-II vs. RY (P < 0.05)).
Mentions: We next compared the lipid-profile changes according to the reconstruction type. No differences in TC, TG or LDL level were apparent for the reconstruction types either 6 or 12 months after surgery. The level of HDL, by contrast, was significantly lower in patients who had undergone Roux-en-Y (RY) reconstruction than in those who had undergone Billroth I or II 12 months after surgery (P = 0.0098) (Figure 2).Figure 2

Bottom Line: The TC level had decreased 6 months after surgery, and remained unchanged thereafter.The LDL level also had decreased 6 months after surgery, but had increased again after 12 months after surgery.Both the male gender and total gastrectomy were associated with probability of normalization of LDL after surgery.

View Article: PubMed Central - PubMed

Affiliation: Department of Surgery, Seoul St. Mary's Hospital, The Catholic University of Korea, College of Medicine, 222 Banpo-daero, Seocho-gu, Seoul, 137-701, Korea. sdf911@naver.com.

ABSTRACT

Background: We investigated the changes of lipid profiles after radical gastrectomy.

Methods: We analyzed the lipid-profile changes after radical gastrectomy in 144 patients with gastric cancer. Their lipid profiles, including total cholesterol (TC), triglyceride (TG), LDL-cholesterol (LDL), and HDL-cholesterol (HDL), were evaluated preoperatively as well as 6 and 12 months postoperatively. We compared the changes of lipid profile according to the reconstruction type and resection extent.

Results: The TC level had decreased 6 months after surgery, and remained unchanged thereafter. The LDL level also had decreased 6 months after surgery, but had increased again after 12 months after surgery. The HDL level had increased 12 months after surgery, whereas the TG level was unchanged. In a comparison of the lipid levels according to the reconstruction type or resection extent, the HDL level significantly differed by reconstruction type 12 months after surgery: it was markedly higher in the total gastrectomy than in the subtotal gastrectomy group both 6 months and 12 months after surgery. Both the male gender and total gastrectomy were associated with probability of normalization of LDL after surgery.

Conclusions: The lipid profiles including the TC, LDL and HDL levels were changed after radical gastrectomy; therefore, after this procedure, the lipid profiles of patients with hyperlipidemia should be evaluated.

Show MeSH
Related in: MedlinePlus