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Changes of lipid profiles after radical gastrectomy in patients with gastric cancer.

Lee JW, Kim EY, Yoo HM, Park CH, Song KY - Lipids Health Dis (2015)

Bottom Line: The TC level had decreased 6 months after surgery, and remained unchanged thereafter.The LDL level also had decreased 6 months after surgery, but had increased again after 12 months after surgery.Both the male gender and total gastrectomy were associated with probability of normalization of LDL after surgery.

View Article: PubMed Central - PubMed

Affiliation: Department of Surgery, Seoul St. Mary's Hospital, The Catholic University of Korea, College of Medicine, 222 Banpo-daero, Seocho-gu, Seoul, 137-701, Korea. sdf911@naver.com.

ABSTRACT

Background: We investigated the changes of lipid profiles after radical gastrectomy.

Methods: We analyzed the lipid-profile changes after radical gastrectomy in 144 patients with gastric cancer. Their lipid profiles, including total cholesterol (TC), triglyceride (TG), LDL-cholesterol (LDL), and HDL-cholesterol (HDL), were evaluated preoperatively as well as 6 and 12 months postoperatively. We compared the changes of lipid profile according to the reconstruction type and resection extent.

Results: The TC level had decreased 6 months after surgery, and remained unchanged thereafter. The LDL level also had decreased 6 months after surgery, but had increased again after 12 months after surgery. The HDL level had increased 12 months after surgery, whereas the TG level was unchanged. In a comparison of the lipid levels according to the reconstruction type or resection extent, the HDL level significantly differed by reconstruction type 12 months after surgery: it was markedly higher in the total gastrectomy than in the subtotal gastrectomy group both 6 months and 12 months after surgery. Both the male gender and total gastrectomy were associated with probability of normalization of LDL after surgery.

Conclusions: The lipid profiles including the TC, LDL and HDL levels were changed after radical gastrectomy; therefore, after this procedure, the lipid profiles of patients with hyperlipidemia should be evaluated.

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Related in: MedlinePlus

Alterations of metabolic parameters 6 and 12 months after gastrectomy in all cohorts (*P < 0.05).
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Fig1: Alterations of metabolic parameters 6 and 12 months after gastrectomy in all cohorts (*P < 0.05).

Mentions: The baseline characteristics of the patients are listed in Table 1. Among the 144 patients, 92 (64%) were men, whose mean BMI mean levels of TC, TG, HDL and LDL were 23.67 kg/m2, 183.89 mg/dl, 94.87 mg/dl, 47.23 mg/dl and 107.25 mg/dl, respectively. Over the course of the 12-month follow, the BMI and lipid profile changed at particular time points (Table 2) (Figure 1). The mean TC level had significantly decreased 6 months postoperatively, from 183. 89 ± 2.84 to 162.66 ± 3.56 mg/dl (P < 0.0001), but remained stagnant thereafter. The mean HDL level had increased significantly 12 months postoperatively, from 47.23 ± 1.01 to 50.40 ± 1.00 mg/dl(P < 0.0012). There was also a significant decrease in the LDL level 6 months postoperatively, from 107.25 ± 2.75 to 86.00 ± 2.59 mg/dl (P < 0.0001), followed by a significant increase 12 months postoperatively to 93.65 ± 2.43 mg/dl(P < 0.0001). However, no significant changes of TG level were observed either 6 or 12 months after surgery.Table 1


Changes of lipid profiles after radical gastrectomy in patients with gastric cancer.

Lee JW, Kim EY, Yoo HM, Park CH, Song KY - Lipids Health Dis (2015)

Alterations of metabolic parameters 6 and 12 months after gastrectomy in all cohorts (*P < 0.05).
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4374421&req=5

Fig1: Alterations of metabolic parameters 6 and 12 months after gastrectomy in all cohorts (*P < 0.05).
Mentions: The baseline characteristics of the patients are listed in Table 1. Among the 144 patients, 92 (64%) were men, whose mean BMI mean levels of TC, TG, HDL and LDL were 23.67 kg/m2, 183.89 mg/dl, 94.87 mg/dl, 47.23 mg/dl and 107.25 mg/dl, respectively. Over the course of the 12-month follow, the BMI and lipid profile changed at particular time points (Table 2) (Figure 1). The mean TC level had significantly decreased 6 months postoperatively, from 183. 89 ± 2.84 to 162.66 ± 3.56 mg/dl (P < 0.0001), but remained stagnant thereafter. The mean HDL level had increased significantly 12 months postoperatively, from 47.23 ± 1.01 to 50.40 ± 1.00 mg/dl(P < 0.0012). There was also a significant decrease in the LDL level 6 months postoperatively, from 107.25 ± 2.75 to 86.00 ± 2.59 mg/dl (P < 0.0001), followed by a significant increase 12 months postoperatively to 93.65 ± 2.43 mg/dl(P < 0.0001). However, no significant changes of TG level were observed either 6 or 12 months after surgery.Table 1

Bottom Line: The TC level had decreased 6 months after surgery, and remained unchanged thereafter.The LDL level also had decreased 6 months after surgery, but had increased again after 12 months after surgery.Both the male gender and total gastrectomy were associated with probability of normalization of LDL after surgery.

View Article: PubMed Central - PubMed

Affiliation: Department of Surgery, Seoul St. Mary's Hospital, The Catholic University of Korea, College of Medicine, 222 Banpo-daero, Seocho-gu, Seoul, 137-701, Korea. sdf911@naver.com.

ABSTRACT

Background: We investigated the changes of lipid profiles after radical gastrectomy.

Methods: We analyzed the lipid-profile changes after radical gastrectomy in 144 patients with gastric cancer. Their lipid profiles, including total cholesterol (TC), triglyceride (TG), LDL-cholesterol (LDL), and HDL-cholesterol (HDL), were evaluated preoperatively as well as 6 and 12 months postoperatively. We compared the changes of lipid profile according to the reconstruction type and resection extent.

Results: The TC level had decreased 6 months after surgery, and remained unchanged thereafter. The LDL level also had decreased 6 months after surgery, but had increased again after 12 months after surgery. The HDL level had increased 12 months after surgery, whereas the TG level was unchanged. In a comparison of the lipid levels according to the reconstruction type or resection extent, the HDL level significantly differed by reconstruction type 12 months after surgery: it was markedly higher in the total gastrectomy than in the subtotal gastrectomy group both 6 months and 12 months after surgery. Both the male gender and total gastrectomy were associated with probability of normalization of LDL after surgery.

Conclusions: The lipid profiles including the TC, LDL and HDL levels were changed after radical gastrectomy; therefore, after this procedure, the lipid profiles of patients with hyperlipidemia should be evaluated.

Show MeSH
Related in: MedlinePlus