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Formulation and evaluation of galantamine gel as drug reservoir in transdermal patch delivery system.

Fong Yen W, Basri M, Ahmad M, Ismail M - ScientificWorldJournal (2015)

Bottom Line: Transdermal delivery of galantamine hydrobromide could avoid these unwanted side effects.The gel also showed high drug content uniformity.Hence, this formulation can be further used in the preparation of transdermal patch drug delivery system.

View Article: PubMed Central - PubMed

Affiliation: Department of Chemistry, Faculty of Science, Universiti Putra Malaysia, 43300 Serdang, Selangor, Malaysia.

ABSTRACT
Galantamine hydrobromide is formulated in tablets and capsules prescribed through oral delivery for the treatment of Alzheimer's disease. However, oral delivery of drugs can cause severe side effects such as nausea, vomiting, and gastrointestinal disturbance. Transdermal delivery of galantamine hydrobromide could avoid these unwanted side effects. In this work, galantamine hydrobromide was formulated in gel drug reservoir which was then fabricated in the transdermal patch. The in vitro drug release studies revealed that the drug release from the donor chamber to receptor chamber of Franz diffusion cell was affected by the amount of polymer, amount of neutralizer, amount of drug, types of permeation enhancer, and amount of permeation enhancer. Visual observations of the gels showed that all formulated gels are translucent, homogeneous, smooth, and stable. These gels have pH in the suitable range for skin. The gel also showed high drug content uniformity. Hence, this formulation can be further used in the preparation of transdermal patch drug delivery system.

No MeSH data available.


Related in: MedlinePlus

Drug release profile of gel drug reservoirs with different propylene glycol percentage (mean ± S.D.; n = 3).
© Copyright Policy - open-access
Related In: Results  -  Collection


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fig5: Drug release profile of gel drug reservoirs with different propylene glycol percentage (mean ± S.D.; n = 3).

Mentions: Propylene glycol showed the highest drug release when compared to other penetration enhancers. Figure 5 and Table 2 show the effects of propylene glycol amount (0.00%, 1.00%, 5.00%, and 10.00% w/w) on drug release. There was no significant improvement on drug permeability when the amount of propylene glycol was increased from 0.00% to 1.00% w/w. However, an improvement in drug release percentage was observed when percentage of propylene glycol was increased from 5.00% to 10.00% w/w. The highest drug release percentage was observed with gel which consisted of 10.00% w/w propylene glycol. Santos et al. and Trottet et al. also deduced that propylene glycol content in the formulations is directly proportional to the amount of drug permeated and drug release [19, 20].


Formulation and evaluation of galantamine gel as drug reservoir in transdermal patch delivery system.

Fong Yen W, Basri M, Ahmad M, Ismail M - ScientificWorldJournal (2015)

Drug release profile of gel drug reservoirs with different propylene glycol percentage (mean ± S.D.; n = 3).
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4374332&req=5

fig5: Drug release profile of gel drug reservoirs with different propylene glycol percentage (mean ± S.D.; n = 3).
Mentions: Propylene glycol showed the highest drug release when compared to other penetration enhancers. Figure 5 and Table 2 show the effects of propylene glycol amount (0.00%, 1.00%, 5.00%, and 10.00% w/w) on drug release. There was no significant improvement on drug permeability when the amount of propylene glycol was increased from 0.00% to 1.00% w/w. However, an improvement in drug release percentage was observed when percentage of propylene glycol was increased from 5.00% to 10.00% w/w. The highest drug release percentage was observed with gel which consisted of 10.00% w/w propylene glycol. Santos et al. and Trottet et al. also deduced that propylene glycol content in the formulations is directly proportional to the amount of drug permeated and drug release [19, 20].

Bottom Line: Transdermal delivery of galantamine hydrobromide could avoid these unwanted side effects.The gel also showed high drug content uniformity.Hence, this formulation can be further used in the preparation of transdermal patch drug delivery system.

View Article: PubMed Central - PubMed

Affiliation: Department of Chemistry, Faculty of Science, Universiti Putra Malaysia, 43300 Serdang, Selangor, Malaysia.

ABSTRACT
Galantamine hydrobromide is formulated in tablets and capsules prescribed through oral delivery for the treatment of Alzheimer's disease. However, oral delivery of drugs can cause severe side effects such as nausea, vomiting, and gastrointestinal disturbance. Transdermal delivery of galantamine hydrobromide could avoid these unwanted side effects. In this work, galantamine hydrobromide was formulated in gel drug reservoir which was then fabricated in the transdermal patch. The in vitro drug release studies revealed that the drug release from the donor chamber to receptor chamber of Franz diffusion cell was affected by the amount of polymer, amount of neutralizer, amount of drug, types of permeation enhancer, and amount of permeation enhancer. Visual observations of the gels showed that all formulated gels are translucent, homogeneous, smooth, and stable. These gels have pH in the suitable range for skin. The gel also showed high drug content uniformity. Hence, this formulation can be further used in the preparation of transdermal patch drug delivery system.

No MeSH data available.


Related in: MedlinePlus