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Prevalence of glutathione S-transferase M1 polymorphism in tobacco users, oral leukoplakia and oral squamous cell carcinoma patients in South Indian population: A polymerase chain reaction study.

Tanwar R, Iyengar AR, Nagesh KS, Patil S, Subhash BV - Contemp Clin Dent (2015)

Bottom Line: Factors that influence tobacco-exposed individuals developing a malignancy may include a combination of total tobacco exposure and genetic susceptibility.This case-control study was conducted in hospital setting on South Indian population.Three milliliter of blood was collected and transported under cold cycle and taken for evaluation of GSTM1 polymorphism using Multiplex Polymerase Chain Reaction.

View Article: PubMed Central - PubMed

Affiliation: Department of Oral Medicine and Radiology, SGT Dental College, Haryana, India.

ABSTRACT

Context: Tobacco abuse is a well-known risk factor for potentially malignant disorders as well as oral squamous cell carcinoma (SCC). Factors that influence tobacco-exposed individuals developing a malignancy may include a combination of total tobacco exposure and genetic susceptibility.

Aim: This study was undertaken to determine the prevalence of the glutathione S-transferase M1 (GSTM1) polymorphism in oral leukoplakia and oral SCC patients in South Indian population.

Settings and design: This case-control study was conducted in hospital setting on South Indian population.

Materials and methods: Totally, 280 subjects with a history of tobacco use, oral leukoplakia, oral SCC were included in this study. Three milliliter of blood was collected and transported under cold cycle and taken for evaluation of GSTM1 polymorphism using Multiplex Polymerase Chain Reaction.

Results and discussion: On comparing the prevalence of GSTM1 polymorphism among the group with subjects with habits and no oral lesions, oral leukoplakia and oral SCC, it was observed that there was a statistically significant association between GSTM1 polymorphism and the different groups (P < 0.01).

Conclusion: The lack of GSTM1 activity would make the oral tissues more susceptible to action of tobacco carcinogens and to the development of a high-grade level of dysplasia in oral leukoplakia and thereby increases the susceptibility of lesion to undergo malignant changes.

No MeSH data available.


Related in: MedlinePlus

Representation of the presence of glutathione S-transferase M1  polymorphism in oral squamous cell carcinoma and subjects with habits and no oral lesions
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Figure 3: Representation of the presence of glutathione S-transferase M1 polymorphism in oral squamous cell carcinoma and subjects with habits and no oral lesions

Mentions: In subjects with oral SCC (Group C), GSTM1 genotype was found in 70 subjects (87%) in our study. Within Group C, GSTM1 genotype was found in 60 subjects (75%) with histological moderately differentiated oral SCC and 10 subjects with well-differentiated oral SCC [Table 3]. The proportion of subjects with GSTM1 polymorphism is higher in SCC group (Group C) compared to subjects with habits and no lesions group (Group A) [Table 4 and Graph 2]. A statistically significant difference was found between subjects in Groups C and A with GSTM1 polymorphism (P < 0.01) in our study.


Prevalence of glutathione S-transferase M1 polymorphism in tobacco users, oral leukoplakia and oral squamous cell carcinoma patients in South Indian population: A polymerase chain reaction study.

Tanwar R, Iyengar AR, Nagesh KS, Patil S, Subhash BV - Contemp Clin Dent (2015)

Representation of the presence of glutathione S-transferase M1  polymorphism in oral squamous cell carcinoma and subjects with habits and no oral lesions
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4374322&req=5

Figure 3: Representation of the presence of glutathione S-transferase M1 polymorphism in oral squamous cell carcinoma and subjects with habits and no oral lesions
Mentions: In subjects with oral SCC (Group C), GSTM1 genotype was found in 70 subjects (87%) in our study. Within Group C, GSTM1 genotype was found in 60 subjects (75%) with histological moderately differentiated oral SCC and 10 subjects with well-differentiated oral SCC [Table 3]. The proportion of subjects with GSTM1 polymorphism is higher in SCC group (Group C) compared to subjects with habits and no lesions group (Group A) [Table 4 and Graph 2]. A statistically significant difference was found between subjects in Groups C and A with GSTM1 polymorphism (P < 0.01) in our study.

Bottom Line: Factors that influence tobacco-exposed individuals developing a malignancy may include a combination of total tobacco exposure and genetic susceptibility.This case-control study was conducted in hospital setting on South Indian population.Three milliliter of blood was collected and transported under cold cycle and taken for evaluation of GSTM1 polymorphism using Multiplex Polymerase Chain Reaction.

View Article: PubMed Central - PubMed

Affiliation: Department of Oral Medicine and Radiology, SGT Dental College, Haryana, India.

ABSTRACT

Context: Tobacco abuse is a well-known risk factor for potentially malignant disorders as well as oral squamous cell carcinoma (SCC). Factors that influence tobacco-exposed individuals developing a malignancy may include a combination of total tobacco exposure and genetic susceptibility.

Aim: This study was undertaken to determine the prevalence of the glutathione S-transferase M1 (GSTM1) polymorphism in oral leukoplakia and oral SCC patients in South Indian population.

Settings and design: This case-control study was conducted in hospital setting on South Indian population.

Materials and methods: Totally, 280 subjects with a history of tobacco use, oral leukoplakia, oral SCC were included in this study. Three milliliter of blood was collected and transported under cold cycle and taken for evaluation of GSTM1 polymorphism using Multiplex Polymerase Chain Reaction.

Results and discussion: On comparing the prevalence of GSTM1 polymorphism among the group with subjects with habits and no oral lesions, oral leukoplakia and oral SCC, it was observed that there was a statistically significant association between GSTM1 polymorphism and the different groups (P < 0.01).

Conclusion: The lack of GSTM1 activity would make the oral tissues more susceptible to action of tobacco carcinogens and to the development of a high-grade level of dysplasia in oral leukoplakia and thereby increases the susceptibility of lesion to undergo malignant changes.

No MeSH data available.


Related in: MedlinePlus