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Neodymium:Yttrium aluminum garnet laser in the management of oral leukoplakia: A case series.

Das S, Mohammad S, Singh V, Gupta S - Contemp Clin Dent (2015)

Bottom Line: Pain and slough were evaluated by Wicoxon rank test (P = 0.0001 statistically significant) which decreased from 24 h to 1-week and became nil in subsequent follow-ups.Similarly, McNemar's test (P = 0.001 statistically significant) was used for evaluation of burning sensation, paresthesia, infection and recurrences.It is convenient, economical with minimum complications and morbidities.

View Article: PubMed Central - PubMed

Affiliation: Department of Head and Neck Oncology, Mazumdar Shaw Cancer Centre, Narayana Hrudalaya, Bengaluru, Karnataka, India.

ABSTRACT

Objectives: Oral leukoplakia is a nonscrappable whitish patch described as a potentially malignant disorder with high prevalence in India. Besides medicinal treatment, neodymium: Yttrium aluminum garnet (Nd: YAG) laser is also used for the management of oral leukoplakia. This study evaluated the role of Nd: YAG laser in the management of oral leukoplakia and also investigated postoperative complications along with long-term prognosis of the disease.

Settings and designs: The study is a prospective cohort study conducted for 24 months (June 2011 to May 2013) in Lucknow.

Materials and methods: The study comprised of 42 patients, both male and female of Indian origin and diagnosed with oral leukoplakic lesions. Patients with biopsy proven squamous cell carcinoma and medically compromised are excluded from the study. All patients has undergone ablation of lesion by pulsed Nd: YAG laser and were followed after 24 h, 72 h, 1-week and then successively for 1, 3, 6 months and then 1(st) and 2(nd) postoperative years.

Results: Pain and slough were evaluated by Wicoxon rank test (P = 0.0001 statistically significant) which decreased from 24 h to 1-week and became nil in subsequent follow-ups. Similarly, McNemar's test (P = 0.001 statistically significant) was used for evaluation of burning sensation, paresthesia, infection and recurrences. Recurrence was noted in 2 patients but following the second application, there were no recurrences over the period of further follow-up. None of the patient suffered from an infection, paresthesia or anesthesia.

Conclusion: Hence, Nd: YAG laser was found to be effective in ablating leukoplakia. It is convenient, economical with minimum complications and morbidities.

No MeSH data available.


Related in: MedlinePlus

Leukoplakic patch over left lateral surface of the tongue
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Figure 1: Leukoplakic patch over left lateral surface of the tongue

Mentions: Forty-two patients (36 males and 6 females) with clinically diagnosed and histopathologically correlated leukoplakic lesions [Figure 1] were selected for the treatment. All patients were informed about the disease, and written consents were taken for the same. The study was conducted following clearance from an ethical committee of the university. Only patients with mild or moderate dysplasia were included for the study. Patients with severe dysplasia and definable white lesions such as linea alba, lichen planus, white sponge nevus, and biopsy-proven severe dysplasia including carcinoma in situ or squamous cell carcinoma were excluded from the study. Routine blood investigations were done prior to the commencement of treatment.


Neodymium:Yttrium aluminum garnet laser in the management of oral leukoplakia: A case series.

Das S, Mohammad S, Singh V, Gupta S - Contemp Clin Dent (2015)

Leukoplakic patch over left lateral surface of the tongue
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4374315&req=5

Figure 1: Leukoplakic patch over left lateral surface of the tongue
Mentions: Forty-two patients (36 males and 6 females) with clinically diagnosed and histopathologically correlated leukoplakic lesions [Figure 1] were selected for the treatment. All patients were informed about the disease, and written consents were taken for the same. The study was conducted following clearance from an ethical committee of the university. Only patients with mild or moderate dysplasia were included for the study. Patients with severe dysplasia and definable white lesions such as linea alba, lichen planus, white sponge nevus, and biopsy-proven severe dysplasia including carcinoma in situ or squamous cell carcinoma were excluded from the study. Routine blood investigations were done prior to the commencement of treatment.

Bottom Line: Pain and slough were evaluated by Wicoxon rank test (P = 0.0001 statistically significant) which decreased from 24 h to 1-week and became nil in subsequent follow-ups.Similarly, McNemar's test (P = 0.001 statistically significant) was used for evaluation of burning sensation, paresthesia, infection and recurrences.It is convenient, economical with minimum complications and morbidities.

View Article: PubMed Central - PubMed

Affiliation: Department of Head and Neck Oncology, Mazumdar Shaw Cancer Centre, Narayana Hrudalaya, Bengaluru, Karnataka, India.

ABSTRACT

Objectives: Oral leukoplakia is a nonscrappable whitish patch described as a potentially malignant disorder with high prevalence in India. Besides medicinal treatment, neodymium: Yttrium aluminum garnet (Nd: YAG) laser is also used for the management of oral leukoplakia. This study evaluated the role of Nd: YAG laser in the management of oral leukoplakia and also investigated postoperative complications along with long-term prognosis of the disease.

Settings and designs: The study is a prospective cohort study conducted for 24 months (June 2011 to May 2013) in Lucknow.

Materials and methods: The study comprised of 42 patients, both male and female of Indian origin and diagnosed with oral leukoplakic lesions. Patients with biopsy proven squamous cell carcinoma and medically compromised are excluded from the study. All patients has undergone ablation of lesion by pulsed Nd: YAG laser and were followed after 24 h, 72 h, 1-week and then successively for 1, 3, 6 months and then 1(st) and 2(nd) postoperative years.

Results: Pain and slough were evaluated by Wicoxon rank test (P = 0.0001 statistically significant) which decreased from 24 h to 1-week and became nil in subsequent follow-ups. Similarly, McNemar's test (P = 0.001 statistically significant) was used for evaluation of burning sensation, paresthesia, infection and recurrences. Recurrence was noted in 2 patients but following the second application, there were no recurrences over the period of further follow-up. None of the patient suffered from an infection, paresthesia or anesthesia.

Conclusion: Hence, Nd: YAG laser was found to be effective in ablating leukoplakia. It is convenient, economical with minimum complications and morbidities.

No MeSH data available.


Related in: MedlinePlus