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Metastatic hepatocellular carcinoma in the maxilla and mandible, an extremely rare presentation.

Misra SR, Shankar YU, Rastogi V, Maragathavalli G - Contemp Clin Dent (2015)

Bottom Line: Hepatocellular carcinoma (HCC) is a common primary liver malignancy that frequently metastasizes during the course of the disease, but < 1% of cases show oral involvement.Such secondary neoplasms do not have any pathognomonic clinical or radiologic findings, and therefore they pose a diagnostic challenge.A rare case of HCC metastasizing to both the maxilla and mandible is presented, in which the patient succumbed to the disease as a result of the delay in diagnosis.

View Article: PubMed Central - PubMed

Affiliation: Department of Oral Medicine and Radiology, Institute of Dental Sciences, Bhubaneswar, Odisha, India.

ABSTRACT
Malignancy is characterized by anaplasia, invasiveness, and metastasis. Primary oral squamous cell carcinoma is the most prevalent oral malignancy, but secondary malignancy from distant sites have also been reported. Hepatocellular carcinoma (HCC) is a common primary liver malignancy that frequently metastasizes during the course of the disease, but < 1% of cases show oral involvement. Such secondary neoplasms do not have any pathognomonic clinical or radiologic findings, and therefore they pose a diagnostic challenge. Hence, in the differential diagnosis of malignant tumors of the oral cavity, it is essential to consider the occurrence of both primary as well as metastatic tumors despite the low incidence of the latter. A rare case of HCC metastasizing to both the maxilla and mandible is presented, in which the patient succumbed to the disease as a result of the delay in diagnosis.

No MeSH data available.


Related in: MedlinePlus

H and E stained section show proliferation of atypical malignant cells forming nests and cords of malignant appearing hepatocytes with a central lumen. The nuclei appear hyperchromatic with one or more prominent nucleoli. The malignant hepatocytes are separated by dense bundles of collagen
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Figure 7: H and E stained section show proliferation of atypical malignant cells forming nests and cords of malignant appearing hepatocytes with a central lumen. The nuclei appear hyperchromatic with one or more prominent nucleoli. The malignant hepatocytes are separated by dense bundles of collagen

Mentions: An incisional biopsy of the growth present in the right buccal mucosa region was made under local anesthesia. Under low power magnification (×4), Hematoxylin and Eosin stained section shows epithelium and connective tissue. Under higher magnification (×10), the lesion was composed of atypical cells similar to hepatocytes, having eosinophilic granules in the cytoplasm [Figure 6]. These cells proliferate forming nests and cords of malignant appearing hepatocytes with a central lumen. The nuclei appear hyperchromatic with one or more prominent nucleoli. The malignant hepatocytes are separated by dense bundles of collagen [Figure 7] and there is also evidence of hemorrhage. There is presence of overlying parakeratinized stratified squamous epithelium that is thinned out in many areas.


Metastatic hepatocellular carcinoma in the maxilla and mandible, an extremely rare presentation.

Misra SR, Shankar YU, Rastogi V, Maragathavalli G - Contemp Clin Dent (2015)

H and E stained section show proliferation of atypical malignant cells forming nests and cords of malignant appearing hepatocytes with a central lumen. The nuclei appear hyperchromatic with one or more prominent nucleoli. The malignant hepatocytes are separated by dense bundles of collagen
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4374307&req=5

Figure 7: H and E stained section show proliferation of atypical malignant cells forming nests and cords of malignant appearing hepatocytes with a central lumen. The nuclei appear hyperchromatic with one or more prominent nucleoli. The malignant hepatocytes are separated by dense bundles of collagen
Mentions: An incisional biopsy of the growth present in the right buccal mucosa region was made under local anesthesia. Under low power magnification (×4), Hematoxylin and Eosin stained section shows epithelium and connective tissue. Under higher magnification (×10), the lesion was composed of atypical cells similar to hepatocytes, having eosinophilic granules in the cytoplasm [Figure 6]. These cells proliferate forming nests and cords of malignant appearing hepatocytes with a central lumen. The nuclei appear hyperchromatic with one or more prominent nucleoli. The malignant hepatocytes are separated by dense bundles of collagen [Figure 7] and there is also evidence of hemorrhage. There is presence of overlying parakeratinized stratified squamous epithelium that is thinned out in many areas.

Bottom Line: Hepatocellular carcinoma (HCC) is a common primary liver malignancy that frequently metastasizes during the course of the disease, but < 1% of cases show oral involvement.Such secondary neoplasms do not have any pathognomonic clinical or radiologic findings, and therefore they pose a diagnostic challenge.A rare case of HCC metastasizing to both the maxilla and mandible is presented, in which the patient succumbed to the disease as a result of the delay in diagnosis.

View Article: PubMed Central - PubMed

Affiliation: Department of Oral Medicine and Radiology, Institute of Dental Sciences, Bhubaneswar, Odisha, India.

ABSTRACT
Malignancy is characterized by anaplasia, invasiveness, and metastasis. Primary oral squamous cell carcinoma is the most prevalent oral malignancy, but secondary malignancy from distant sites have also been reported. Hepatocellular carcinoma (HCC) is a common primary liver malignancy that frequently metastasizes during the course of the disease, but < 1% of cases show oral involvement. Such secondary neoplasms do not have any pathognomonic clinical or radiologic findings, and therefore they pose a diagnostic challenge. Hence, in the differential diagnosis of malignant tumors of the oral cavity, it is essential to consider the occurrence of both primary as well as metastatic tumors despite the low incidence of the latter. A rare case of HCC metastasizing to both the maxilla and mandible is presented, in which the patient succumbed to the disease as a result of the delay in diagnosis.

No MeSH data available.


Related in: MedlinePlus